Reviewed, UniProtKB/Swiss-Prot Q6G2Q6 (MURC_BARHE)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylmuramate--L-alanine ligase
    EC=6.3.2.8
Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanine synthetase

Gene names

Name:	murC
Ordered Locus Names:	BH11230

Organism

Bartonella henselae (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

38323 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	475 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cell wall formation By similarity.
Catalytic activity	ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the murCDEF family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP UDP-N-acetylmuramate-L-alanine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 475	475	UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046		PRO_0000182056
Regions
	Nucleotide binding	114 – 120	7	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6G2Q6-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: F67F71147FAF579F	FASTA	475	52,078
	10 20 30 40 50 60 MKMPLNIGLI HFVGIGGIGM SGIAEVFHNL GYKVQGSDQI DNANVKRLQD KGIQVHVGHH 70 80 90 100 110 120 AENLGDAEFV VLSTAIKKTN PEYIAAKERH LPLVKRAEML AELMRFRRAI AVGGTHGKTT 130 140 150 160 170 180 TTSMIAALLD AGSFDPMVIN GGIINAYGTN ARMGEGDWMV VEADESDGTF LKLPADIAVV 190 200 210 220 230 240 TNIDREHLDH YGSFAAVRDA FRQFVENVPF YGFAVLCIDH PEVQSLASRI DDRWVITYGA 250 260 270 280 290 300 NPQADIRFLN LSMDGQKTYF DVFMRSRKTG RETELKNLVL PMSGQHNVSN ATAAIAIAHE 310 320 330 340 350 360 LGISNESIKK GLAGFGGVKR RFTQIGSWRG VEIFDDYGHH PVEIKAVLCA ARESAKGRVI 370 380 390 400 410 420 AIAQPHRYSR LYHLFDDFAA CFNDADIVLI APVYAAGEEP ITGFGARELV EHIQMAGHRD 430 440 450 460 470 VRLIDCLEDV VSIVSTFSKS GDYVVFLGAG NITQWACALP NQLAVFDNND KFSAD

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX897699 Genomic DNA. Translation: CAF27908.1.
RefSeq	YP_033895.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2865363.
GenomeReviews	Gene locus BH11230 in contig BX897699_GR.
KEGG	bhe:BH11230.
NMPDR	fig|283166.1.peg.1023.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6G2Q6.
OMA	LAKLMDG.
Enzyme and pathway databases
BioCyc	BHEN283166:BH11230-MON.
BRENDA	6.3.2.8. 277357.
Family and domain databases
HAMAP	MF_00046. [Tree]
InterPro	IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR016040. NAD(P)-bd_dom. IPR005758. UDP-N-AcMur_Ala_ligase. [Graphical view]
Gene3D	G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view]
TIGRFAMs	TIGR01082. murC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURC_BARHE

Accession

Primary (citable) accession number: Q6G2Q6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)