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Reviewed, UniProtKB/Swiss-Prot Q6G2Q3 (MURD_BARHE)

Last modified February 9, 2010. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    UDP-N-acetylmuramoylalanine--D-glutamate ligase
    EC=6.3.2.9
Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
    D-glutamic acid-adding enzyme
Gene names
Name: murD
Ordered Locus Names: BH11260
OrganismBartonella henselae (Rochalimaea henselae) [Complete proteome] [HAMAP]
Taxonomic identifier38323 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

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Protein attributes

Sequence length466 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP MF_00639

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP MF_00639

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00639

Subcellular location

Cytoplasm By similarity HAMAP MF_00639.

Sequence similarities

Belongs to the murCDEF family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 466466UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP MF_00639
PRO_0000108971

Regions

Nucleotide binding128 – 1347ATP Potential

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Sequences

Sequence LengthMass (Da)Tools
Q6G2Q3-1 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: A2EF67B0883925B4

FASTA46650,883
        10         20         30         40         50         60 
MISIAFYKGK KVALFGLGKS GLATAQALIS GGADVVAWDD NPSGVQAAHR ENIPARNLQY 

        70         80         90        100        110        120 
ENWSEFVALI LAPGVPLTYP QPHWVVDKAR QANIEIIGDI ELFVRARNHF LQQYGFCDED 

       130        140        150        160        170        180 
VPFIAITGTN GKSTTTALLA HLLEQMGYDV QMGGNIGTAI LTLKPFVKKR IYVIECSSFQ 

       190        200        210        220        230        240 
IDLAPSLQPT IGLLLNLTPD HIDRHGSFAH YVNAKKNLVT GASQAFISVD DAACQVLYRQ 

       250        260        270        280        290        300 
LLHEGHHVEA VSKEHFVENG FYADGTQLFS VCQGRRHMLA DLASMAALRG SHNAQNALMA 

       310        320        330        340        350        360 
LATLQALKIT DPHMNKHLAS YQGLAHRMQQ VRKMGSVLFI NDSKATNAEA SAPALAAFNN 

       370        380        390        400        410        420 
IFWIVGGQAK EAGIVSLRGF FHKIRKAYLI GAAAEEFAGV IGSSFPFSMS LTLENAVHEA 

       430        440        450        460 
AVDAMRCKAK EVVVLFSPAC ASYDQFKNYE VRGEAFISFV MQLKET

« Hide

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References

[1]"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae."
Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E.
Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49882 / Houston 1.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX897699 Genomic DNA. Translation: CAF27911.1.
RefSeqYP_033898.1.

3D structure databases

SMRQ6G2Q3. Positions 7-463.
ModBaseSearch...

Genome annotation databases

GeneID2865364.
GenomeReviewsGene locus BH11260 in contig BX897699_GR.
KEGGbhe:BH11260.
NMPDRfig|283166.1.peg.1026.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG750024.
OMAVKYYNDS.
PhylomeDBQ6G2Q3.

Enzyme and pathway databases

BioCycBHEN283166:BH11260-MONOMER.
BRENDA6.3.2.9. 277357.

Family and domain databases

HAMAPMF_00639. MurD.
[Tree]
InterProIPR018109. Folylpolyglutamate_synth_CS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF08245. Mur_ligase_M. 1 hit.
[Graphical view]
TIGRFAMsTIGR01087. murD. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameMURD_BARHE
AccessionPrimary (citable) accession number: Q6G2Q3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 19, 2004
Last modified: February 9, 2010
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents