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Q6G2Q2 (MRAY_BARHE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:BH11270
OrganismBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae) [Complete proteome] [HAMAP]
Taxonomic identifier283166 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_0000108785

Regions

Transmembrane25 – 4521Helical; Potential
Transmembrane70 – 9021Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane138 – 15821Helical; Potential
Transmembrane164 – 18421Helical; Potential
Transmembrane195 – 21521Helical; Potential
Transmembrane235 – 25521Helical; Potential
Transmembrane258 – 27821Helical; Potential
Transmembrane284 – 30421Helical; Potential
Transmembrane333 – 35321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q6G2Q2 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 5D284889C561EE68

FASTA35638,537
        10         20         30         40         50         60 
MMLFFSSLSD WLPGVSVFRY ITFRTIAAML TSGLIVFLFG PSIIISLKLR QGKGQPIRAD 

        70         80         90        100        110        120 
GPQTHFKKAG TPTMGGLMIL SGIVVSAFLW CNLSNIYFWV SLFVMLSFGM IGFYDDYLKV 

       130        140        150        160        170        180 
TKQTEKGFSG KARLSLEFLV AAIAAFVFLQ VGSPGLALPF VKDYFINLSW FFIPFSAFVI 

       190        200        210        220        230        240 
VATGNAVNLT DGLDGLAIVP VMVAALSFAL IAYLSGNINF ADYLQIHYVS GTGELAVLLG 

       250        260        270        280        290        300 
AVVGAGLGFL WFNAPPAAIF MGDTGSLALG GLLGSVAVAT KHEIVLALIG GLFALEGFSV 

       310        320        330        340        350 
VIQVGYFKLT KKRAFLMAPI HHHFEKKGWT ESQVVIRFWI ISIVLALIGL STLKLR

« Hide

References

[1]"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae."
Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E.
Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX897699 Genomic DNA. Translation: CAF27912.1.
RefSeqYP_033899.1. NC_005956.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2865625.
GenomeReviewsGene locus BH11270 in contig BX897699_GR.
KEGGbhe:BH11270.
NMPDRfig|283166.1.peg.1027.
PATRIC20546091. VBIBarHen29080_1177.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG708263.
OMARFWIISM.
PhylomeDBQ6G2Q2.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycBHEN283166:BH11270-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BARHE
AccessionPrimary (citable) accession number: Q6G2Q2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 19, 2004
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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