Reviewed, UniProtKB/Swiss-Prot Q6G2G3 (DAPB_BARHE)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	BH12440

Organism

Bartonella henselae (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

38323 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = 2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_0000228326

Sequences

	Sequence		Length	Mass (Da)
	Q6G2G3-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 3E052BE1437F0561	FASTA	267	28,684
	10 20 30 40 50 60 MRLTVVGANG RMGRELITAI QRRKDVELCA VLVRKGSSFV DKDASILIGS DFLGVRITDD 70 80 90 100 110 120 PESAFSNTEG ILDFSQPQAS VLYANYAAQK SLIHIIGTTG FSKTEEAQIA DFAKYTTIVK 130 140 150 160 170 180 SGNMSLGVNL LANLVKRAAK ALDDDFDIEI YEMHHANKVD SPSGTALLLG QAAAEGRNIM 190 200 210 220 230 240 LKNVSVNGRS GHTGKREKGT IGFACSRGGT VIGDHSITFA GENERIVLSH IAQERSIFAN 250 260 GALKAALWAK NHENGLYSML DVLGLNE

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX897699 Genomic DNA. Translation: CAF28026.1.
RefSeq	YP_033998.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2864853.
GenomeReviews	Gene locus BH12440 in contig BX897699_GR.
KEGG	bhe:BH12440.
NMPDR	fig|283166.1.peg.1126.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6G2G3.
OMA	Q6G2G3. TIGFSTI.
Enzyme and pathway databases
BioCyc	BHEN283166:BH12440-MON.
BRENDA	1.3.1.26. 277357.
Family and domain databases
HAMAP	MF_00102. [Tree]
InterPro	IPR000846. DapB. IPR011770. DapB_bac/pln. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
ProDom	PD004105. DapB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_BARHE

Accession

Primary (citable) accession number: Q6G2G3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	July 19, 2004
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)