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Q6G2F1

- GCSP_BARHE

UniProt

Q6G2F1 - GCSP_BARHE

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBHEN283166:GIVZ-1277-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:BH12820
    OrganismiBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
    Taxonomic identifieri283166 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
    ProteomesiUP000000421: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 931931Glycine dehydrogenase (decarboxylating)PRO_0000227093Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei684 – 6841N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi283166.BH12820.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6G2F1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiAELMPVS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6G2F1-1 [UniParc]FASTAAdd to Basket

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    MLERPFFSRH IGLRPDEKQK MLDIVAVDSI DTLVSQALPH SIHLGRPLNL    50
    PKAVSEGQAL EELSKMMERN YLHKSFIGQG YHGTYVPPVI LRNLFENPAW 100
    YTAYTPYQAE ISQGRLELLF YFQTLISELT GLPVAAASLL DEATALAEAI 150
    TVAFRFTREK KMKISLQSLL HPQILSVVQT RAETQGLQVS KNSEICSDTA 200
    AIVLSWPDTK GSFNDYSEVI KEAKAKGALV IVVADPLALT LMEAPAKWGA 250
    DIVVGSMQRY GVPMGFGGPH AGYLAVSDAL TRLIPGRIVG QSVDTKGRVG 300
    FRLALQTREQ HIRRDKATSN ICTAQALLAN MATAYAVWHG PQGLQEIAQR 350
    VHHLTCRFVG GLEAVGISCE GEYFFDCVSI VVKGKAREIA CQAKAGGRLI 400
    RVLDDDRVVI NFDELSTQED AHALAQLFGA GLVDQASPRL MGKGRDTTFL 450
    SQPFFHAVHS ETDMMRFLRR LSDKDLALDR AMIPLGSCTM KLNAAAELMP 500
    VSWPTVANIH PFASREDAVG YQEMIHQLNA WLCEITGFAQ VSFQPNSGAQ 550
    GEYAGLLAIR RYHQSRGEHQ RTLCLIPASA HGTNPASAHM AGMEVVVVKC 600
    LNDGDVDLDD LKMKAQLYKE RLAALMITYP STHGVYEESI KDICSLIHEN 650
    GGQVYFDGAN LNALVGLARP ADIGADVCHM NLHKTFAIPH GGGGPGVGPI 700
    GVVEHLKPFL PGHEQEGTTH AVSAAPYGSA SILVITWMYI RMMGAEGLKY 750
    ATQTAILNAN YIAARLSQVY SILYRGKHGR VAHECIVDTR VLKEQYGVSV 800
    DDIAKRLIDY GFHAPTMSFP VPGTLMIEPT ESEPKAEIDR FCDALLSIAE 850
    EAKKIGSGVW PKDDNPLVHA PHTLVDTLDD TWARPYSRQE AAFPNCSLDP 900
    ANKYWPPVSR IDNVAGDRML ICSCPPLGNT Y 931
    Length:931
    Mass (Da):101,973
    Last modified:July 19, 2004 - v1
    Checksum:iAE803D14096288F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX897699 Genomic DNA. Translation: CAF28056.1.
    RefSeqiWP_011181096.1. NC_005956.1.
    YP_034020.1. NC_005956.1.

    Genome annotation databases

    EnsemblBacteriaiCAF28056; CAF28056; BH12820.
    GeneIDi2864735.
    KEGGibhe:BH12820.
    PATRICi20546483. VBIBarHen29080_1363.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX897699 Genomic DNA. Translation: CAF28056.1 .
    RefSeqi WP_011181096.1. NC_005956.1.
    YP_034020.1. NC_005956.1.

    3D structure databases

    ProteinModelPortali Q6G2F1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 283166.BH12820.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF28056 ; CAF28056 ; BH12820 .
    GeneIDi 2864735.
    KEGGi bhe:BH12820.
    PATRICi 20546483. VBIBarHen29080_1363.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi AELMPVS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci BHEN283166:GIVZ-1277-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49882 / Houston 1.

    Entry informationi

    Entry nameiGCSP_BARHE
    AccessioniPrimary (citable) accession number: Q6G2F1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3