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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBHEN283166:GIVZ-1277-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:BH12820
OrganismiBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000421: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 931931Glycine dehydrogenase (decarboxylating)PRO_0000227093Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei684 – 6841N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi283166.BH12820.

Structurei

3D structure databases

ProteinModelPortaliQ6G2F1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiPHYKTLY.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6G2F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLERPFFSRH IGLRPDEKQK MLDIVAVDSI DTLVSQALPH SIHLGRPLNL
60 70 80 90 100
PKAVSEGQAL EELSKMMERN YLHKSFIGQG YHGTYVPPVI LRNLFENPAW
110 120 130 140 150
YTAYTPYQAE ISQGRLELLF YFQTLISELT GLPVAAASLL DEATALAEAI
160 170 180 190 200
TVAFRFTREK KMKISLQSLL HPQILSVVQT RAETQGLQVS KNSEICSDTA
210 220 230 240 250
AIVLSWPDTK GSFNDYSEVI KEAKAKGALV IVVADPLALT LMEAPAKWGA
260 270 280 290 300
DIVVGSMQRY GVPMGFGGPH AGYLAVSDAL TRLIPGRIVG QSVDTKGRVG
310 320 330 340 350
FRLALQTREQ HIRRDKATSN ICTAQALLAN MATAYAVWHG PQGLQEIAQR
360 370 380 390 400
VHHLTCRFVG GLEAVGISCE GEYFFDCVSI VVKGKAREIA CQAKAGGRLI
410 420 430 440 450
RVLDDDRVVI NFDELSTQED AHALAQLFGA GLVDQASPRL MGKGRDTTFL
460 470 480 490 500
SQPFFHAVHS ETDMMRFLRR LSDKDLALDR AMIPLGSCTM KLNAAAELMP
510 520 530 540 550
VSWPTVANIH PFASREDAVG YQEMIHQLNA WLCEITGFAQ VSFQPNSGAQ
560 570 580 590 600
GEYAGLLAIR RYHQSRGEHQ RTLCLIPASA HGTNPASAHM AGMEVVVVKC
610 620 630 640 650
LNDGDVDLDD LKMKAQLYKE RLAALMITYP STHGVYEESI KDICSLIHEN
660 670 680 690 700
GGQVYFDGAN LNALVGLARP ADIGADVCHM NLHKTFAIPH GGGGPGVGPI
710 720 730 740 750
GVVEHLKPFL PGHEQEGTTH AVSAAPYGSA SILVITWMYI RMMGAEGLKY
760 770 780 790 800
ATQTAILNAN YIAARLSQVY SILYRGKHGR VAHECIVDTR VLKEQYGVSV
810 820 830 840 850
DDIAKRLIDY GFHAPTMSFP VPGTLMIEPT ESEPKAEIDR FCDALLSIAE
860 870 880 890 900
EAKKIGSGVW PKDDNPLVHA PHTLVDTLDD TWARPYSRQE AAFPNCSLDP
910 920 930
ANKYWPPVSR IDNVAGDRML ICSCPPLGNT Y
Length:931
Mass (Da):101,973
Last modified:July 19, 2004 - v1
Checksum:iAE803D14096288F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897699 Genomic DNA. Translation: CAF28056.1.
RefSeqiYP_034020.1. NC_005956.1.

Genome annotation databases

EnsemblBacteriaiCAF28056; CAF28056; BH12820.
GeneIDi2864735.
KEGGibhe:BH12820.
PATRICi20546483. VBIBarHen29080_1363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897699 Genomic DNA. Translation: CAF28056.1.
RefSeqiYP_034020.1. NC_005956.1.

3D structure databases

ProteinModelPortaliQ6G2F1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283166.BH12820.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF28056; CAF28056; BH12820.
GeneIDi2864735.
KEGGibhe:BH12820.
PATRICi20546483. VBIBarHen29080_1363.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiPHYKTLY.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciBHEN283166:GIVZ-1277-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49882 / Houston 1.

Entry informationi

Entry nameiGCSP_BARHE
AccessioniPrimary (citable) accession number: Q6G2F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 19, 2004
Last modified: March 4, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.