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Protein

Glycine cleavage system H protein

Gene

gcvH

Organism
Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Biological processi

Enzyme and pathway databases

BioCyciBHEN283166:G1GJ7-1303-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine cleavage system H proteinUniRule annotation
Gene namesi
Name:gcvHUniRule annotation
Ordered Locus Names:BH12830
OrganismiBartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000421 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003023551 – 122Glycine cleavage system H proteinAdd BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60N6-lipoyllysineUniRule annotation1

Proteomic databases

PaxDbiQ6G2F0
PRIDEiQ6G2F0

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi283166.BH12830

Structurei

Secondary structure

1122
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 6Combined sources4
Beta strandi8 – 16Combined sources9
Beta strandi19 – 24Combined sources6
Helixi26 – 32Combined sources7
Beta strandi34 – 39Combined sources6
Beta strandi52 – 60Combined sources9
Beta strandi62 – 66Combined sources5
Beta strandi68 – 76Combined sources9
Helixi78 – 81Combined sources4
Helixi86 – 89Combined sources4
Turni91 – 95Combined sources5
Beta strandi98 – 101Combined sources4
Helixi106 – 113Combined sources8
Beta strandi116 – 119Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MXUX-ray1.80A1-122[»]
ProteinModelPortaliQ6G2F0
SMRiQ6G2F0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6G2F0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 101Lipoyl-bindingPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Belongs to the GcvH family.UniRule annotation

Keywords - Domaini

Lipoyl

Phylogenomic databases

eggNOGiENOG4105KE9 Bacteria
COG0509 LUCA
HOGENOMiHOG000239392
KOiK02437
OMAiIVYVEVE
OrthoDBiPOG091H04TZ

Family and domain databases

CDDicd06848 GCS_H, 1 hit
HAMAPiMF_00272 GcvH, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR000089 Biotin_lipoyl
IPR002930 GCV_H
IPR033753 GCV_H/Fam206
IPR017453 GCV_H_sub
IPR011053 Single_hybrid_motif
PANTHERiPTHR11715 PTHR11715, 1 hit
PfamiView protein in Pfam
PF01597 GCV_H, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR00527 gcvH, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00189 LIPOYL, 1 hit

Sequencei

Sequence statusi: Complete.

Q6G2F0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKTYFTQDH EWLSVEGQVV TVGITDYAQE QLGDLVFIDL PQNGTKLSKG
60 70 80 90 100
DAAAVVESVK AASDVYAPLD GEVVEINAAL AESPELVNQK AETEGWLWKM
110 120
TVQDETQLER LLDEAAYKEL IG
Length:122
Mass (Da):13,403
Last modified:July 19, 2004 - v1
Checksum:i2FE4925EEC5DD966
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897699 Genomic DNA Translation: CAF28057.1
RefSeqiWP_011181097.1, NZ_LRIJ01000002.1

Genome annotation databases

EnsemblBacteriaiCAF28057; CAF28057; BH12830
GeneIDi29621486
KEGGibhe:BH12830

Similar proteinsi

Entry informationi

Entry nameiGCSH_BARHE
AccessioniPrimary (citable) accession number: Q6G2F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 19, 2004
Last modified: February 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome