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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei641ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBHEN283166:G1GJ7-1607-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BH15390
OrganismiBartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000421 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001519751 – 880Leucine--tRNA ligaseAdd BLAST880

Proteomic databases

PaxDbiQ6G1W2
PRIDEiQ6G1W2

Interactioni

Protein-protein interaction databases

STRINGi283166.BH15390

Structurei

3D structure databases

ProteinModelPortaliQ6G1W2
SMRiQ6G1W2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi49 – 59"HIGH" regionAdd BLAST11
Motifi638 – 642"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q6G1W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIEHYNLGE RYNPRACERK WQAIWDEKKT FQTVQEDRRE KYYVLEMFPY
60 70 80 90 100
PSGRIHMGHV RNYAMGDVVA RYKRAKGFNV LHPMGWDAFG MPAENAAMQN
110 120 130 140 150
KVHPKTWTYQ NIAVMRGQLK QLGLSVDWSR EFATCDVDYY HRQQMLFLDF
160 170 180 190 200
YQKGLVARKV AKVNWDPVDQ TVLANEQVVD GRGWRSGALV EQRELTQWFF
210 220 230 240 250
KISDFSEDLL AGLEELEQWP EKVRIMQKNW IGKSQGLLIR WALKSTEEAD
260 270 280 290 300
EVCKSFDEVV CYSTRPDTLF GASFLALSVD HPLAQALAQK DKALEFFIEN
310 320 330 340 350
CRSGGTTTAE LETAEKQGFR TSLVAVHPFD VAVHIPVYIA NFVLMDYGTG
360 370 380 390 400
AVFGCPAHDQ RDFDFARKYD LPVQPVVLPS GVEREDFAIT ETPYLGDGVM
410 420 430 440 450
INSSFLDGLT PQQAFEEAAK RLEGQMLNGK PQAEKTVQFR LRDWGISRQR
460 470 480 490 500
YWGCPIPMIH CTSCGVVPVP RADLPVVLPD DVTFEQPGNP LVCHETWKSV
510 520 530 540 550
ACPVCGQFAK RETDTMDTFV DSSWYYARFT APFAQEPVDK KATTEWLPVQ
560 570 580 590 600
QYIGGIEHAI LHLLYARFFT RAMKSMGYVT VDEPFKGLFT QGMVVHETYR
610 620 630 640 650
DEKDWVSPEE ISIVEKDGKR QAYKLTDQSE VTIGSIEKMS KSKKNVVDPD
660 670 680 690 700
DIIASYGADT VRWFILSDSP PERDVIWTES GVEGAHRFVQ RVWRCVALSA
710 720 730 740 750
PVLRDVVPCV GKQGAALQLS KVAHRTLYAV EDDLEKFAFN RAIARLYEFL
760 770 780 790 800
NIMAPLLNRI ENVEDEMKAA LRQAMDFFLA MIAPIMPHLA EECHAALGEK
810 820 830 840 850
TLISELAWPV CDRALTVEEC YTLPVQINGK KRGEVTVAAT ASEAMIEEAV
860 870 880
LALDFVKVHL VKKPVKKMII VPKRIVNVVL
Length:880
Mass (Da):100,077
Last modified:July 19, 2004 - v1
Checksum:i5589AC710AB5F1B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897699 Genomic DNA Translation: CAF28302.1
RefSeqiWP_011181305.1, NZ_LRIJ02000001.1

Genome annotation databases

EnsemblBacteriaiCAF28302; CAF28302; BH15390
GeneIDi29621785
KEGGibhe:BH15390

Similar proteinsi

Entry informationi

Entry nameiSYL_BARHE
AccessioniPrimary (citable) accession number: Q6G1W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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