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Q6G1W2

- SYL_BARHE

UniProt

Q6G1W2 - SYL_BARHE

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei641 – 6411ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBHEN283166:GIVZ-1534-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BH15390
    OrganismiBartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae)
    Taxonomic identifieri283166 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
    ProteomesiUP000000421: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 880880Leucine--tRNA ligasePRO_0000151975Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi283166.BH15390.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6G1W2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi49 – 5911"HIGH" regionAdd
    BLAST
    Motifi638 – 6425"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6G1W2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTIEHYNLGE RYNPRACERK WQAIWDEKKT FQTVQEDRRE KYYVLEMFPY    50
    PSGRIHMGHV RNYAMGDVVA RYKRAKGFNV LHPMGWDAFG MPAENAAMQN 100
    KVHPKTWTYQ NIAVMRGQLK QLGLSVDWSR EFATCDVDYY HRQQMLFLDF 150
    YQKGLVARKV AKVNWDPVDQ TVLANEQVVD GRGWRSGALV EQRELTQWFF 200
    KISDFSEDLL AGLEELEQWP EKVRIMQKNW IGKSQGLLIR WALKSTEEAD 250
    EVCKSFDEVV CYSTRPDTLF GASFLALSVD HPLAQALAQK DKALEFFIEN 300
    CRSGGTTTAE LETAEKQGFR TSLVAVHPFD VAVHIPVYIA NFVLMDYGTG 350
    AVFGCPAHDQ RDFDFARKYD LPVQPVVLPS GVEREDFAIT ETPYLGDGVM 400
    INSSFLDGLT PQQAFEEAAK RLEGQMLNGK PQAEKTVQFR LRDWGISRQR 450
    YWGCPIPMIH CTSCGVVPVP RADLPVVLPD DVTFEQPGNP LVCHETWKSV 500
    ACPVCGQFAK RETDTMDTFV DSSWYYARFT APFAQEPVDK KATTEWLPVQ 550
    QYIGGIEHAI LHLLYARFFT RAMKSMGYVT VDEPFKGLFT QGMVVHETYR 600
    DEKDWVSPEE ISIVEKDGKR QAYKLTDQSE VTIGSIEKMS KSKKNVVDPD 650
    DIIASYGADT VRWFILSDSP PERDVIWTES GVEGAHRFVQ RVWRCVALSA 700
    PVLRDVVPCV GKQGAALQLS KVAHRTLYAV EDDLEKFAFN RAIARLYEFL 750
    NIMAPLLNRI ENVEDEMKAA LRQAMDFFLA MIAPIMPHLA EECHAALGEK 800
    TLISELAWPV CDRALTVEEC YTLPVQINGK KRGEVTVAAT ASEAMIEEAV 850
    LALDFVKVHL VKKPVKKMII VPKRIVNVVL 880
    Length:880
    Mass (Da):100,077
    Last modified:July 19, 2004 - v1
    Checksum:i5589AC710AB5F1B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX897699 Genomic DNA. Translation: CAF28302.1.
    RefSeqiYP_034235.1. NC_005956.1.

    Genome annotation databases

    EnsemblBacteriaiCAF28302; CAF28302; BH15390.
    GeneIDi2865580.
    KEGGibhe:BH15390.
    PATRICi20547354. VBIBarHen29080_1785.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX897699 Genomic DNA. Translation: CAF28302.1 .
    RefSeqi YP_034235.1. NC_005956.1.

    3D structure databases

    ProteinModelPortali Q6G1W2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 283166.BH15390.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF28302 ; CAF28302 ; BH15390 .
    GeneIDi 2865580.
    KEGGi bhe:BH15390.
    PATRICi 20547354. VBIBarHen29080_1785.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BHEN283166:GIVZ-1534-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49882 / Houston 1.

    Entry informationi

    Entry nameiSYL_BARHE
    AccessioniPrimary (citable) accession number: Q6G1W2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3