Reviewed, UniProtKB/Swiss-Prot Q6G1W0 (ACSA_BARHE)

Names and origin

Protein names

Recommended name:
    Acetyl-coenzyme A synthetase
    EC=6.2.1.1
Alternative name(s):
    Acetate--CoA ligase
    Acyl-activating enzyme

Gene names

Name:	acsA
Ordered Locus Names:	BH15410

Organism

Bartonella henselae (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

38323 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	652 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 652	652	Acetyl-coenzyme A synthetase HAMAP MF_01123		PRO_1000065270
Sites
	Active site	517	1	By similarity
Amino acid modifications
	Modified residue	609	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6G1W0-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 9091B62C2E782DFD	FASTA	652	73,577
	10 20 30 40 50 60 MSEKIYPIPD NIKKNALIDE ETYQQWYQES INDPESFWAK HGQCIEWFKP YTKVKNTSFN 70 80 90 100 110 120 GDVSIQWYED GITNVAYNCI DRHLKTHGDK IALIWEGDNP YHDKKITYNE LYEHVCRFAN 130 140 150 160 170 180 ILKNHGVKKG DKVTIYLTMI PEAAYAMLAC ARIGAIHSVI FAGFSPEAIA GRIVDCESTF 190 200 210 220 230 240 IITANQGLRG GKQINLKDSV DHAIEIAARQ NVHVDQVMVI RRTCGPIHWV EGRDFWYHEE 250 260 270 280 290 300 VSHTKTDCPA EKMNAEDPLF ILYTSGSTGK PKGVLHTTAG YLVYASMTHK YVFDYHAGEI 310 320 330 340 350 360 YWCTADIGWI TGHSYLVYGP LCNAATTLMF EGTPTFPDNG RFWEIVDKHQ VNIFYTAPTA 370 380 390 400 410 420 IRALMGAGNS FVERSKRTSL RLLGSVGEPI NPEAWEWFYH TVGNNHCPIL DTWWQTETGG 430 440 450 460 470 480 HMITPLPGAT PLKAGSATRP FFGVQLQIID AEGNVLEGET EGNLCIIDSW PGQMRTLYND 490 500 510 520 530 540 HERFIQTYFS TYKGKYFTGD GCRRDSDGYY WITGRVDDIL NVSGHRLGTA EIESALVSHP 550 560 570 580 590 600 AVSEAAVVGY PHTIKGQGIY SFITLMEGTA PSEELHQELI RHVRKEIGSI AILDKVQFAP 610 620 630 640 650 QLPKTRSGKI MRRILRKIAE NNFDNLGDIS TLSEPQVIDD LIANRQNREI TA

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897699 Genomic DNA. Translation: CAF28304.1.
RefSeq	YP_034237.1.
3D structure databases
HSSP	HSSP built from PDB template 1PG4 based on UniProtKB Q8ZKF6.
SMR	Q6G1W0. Positions 6-646.
ModBase	Search...
Genome annotation databases
GeneID	2866062.
GenomeReviews	Gene locus BH15410 in contig BX897699_GR.
KEGG	bhe:BH15410.
NMPDR	fig|283166.1.peg.1365.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG547964.
OMA	TRVKNTS.
PhylomeDB	Q6G1W0.
Enzyme and pathway databases
BioCyc	BHEN283166:BH15410-MONOMER.
BRENDA	6.2.1.1. 277357.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig_AcsA. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACSA_BARHE

Accession

Primary (citable) accession number: Q6G1W0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)