Reviewed, UniProtKB/Swiss-Prot Q6G1N9 (AROK_BARHE)

Names and origin

Protein names

Recommended name:
    Shikimate kinase
      Short name=SK
    EC=2.7.1.71

Gene names

Name:	aroK
Ordered Locus Names:	BH16360

Organism

Bartonella henselae (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

38323 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity.
Catalytic activity	ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP MF_00109
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP MF_00109
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the shikimate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP shikimate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Shikimate kinase HAMAP MF_00109		PRO_0000237845
Regions
	Nucleotide binding	34 – 39	6	ATP By similarity
Sites
	Metal binding	38	1	Magnesium By similarity
	Binding site	56	1	Substrate By similarity
	Binding site	80	1	Substrate By similarity
	Binding site	102	1	Substrate; via amide nitrogen By similarity
	Binding site	140	1	ATP By similarity
	Binding site	159	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6G1N9-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 80BDBB11FEE0B6E2	FASTA	210	24,094
	10 20 30 40 50 60 MKSNRPKHIP ITKIKNQLLS SLDNRALVLI GLMGVGKSVI GKRIATMLCL PFYDSDQEIE 70 80 90 100 110 120 KAAQMTITEL FKTYGESEFR ALEQRVILNL MKNRPLVLAT GGGAYINEDI RKAVHKNGIS 130 140 150 160 170 180 IWLKVDLDTL MQRVSKRPTR PLLQTENPKE TMQKLMKQRY PIYAKANLTI NSHKENRQTV 190 200 210 AQNVIRSVQH YLDTEKNDRN NQHANQNCHC

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX897699 Genomic DNA. Translation: CAF28398.1.
RefSeq	YP_034328.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2866081.
GenomeReviews	Gene locus BH16360 in contig BX897699_GR.
KEGG	bhe:BH16360.
NMPDR	fig|283166.1.peg.1456.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6G1N9.
OMA	HANVFFV.
Enzyme and pathway databases
BioCyc	BHEN283166:BH16360-MON.
BRENDA	2.7.1.71. 277357.
Family and domain databases
HAMAP	MF_00109. [Tree]
InterPro	IPR000623. Shik_kinase. [Graphical view]
Pfam	PF01202. SKI. 1 hit. [Graphical view]
PRINTS	PR01100. SHIKIMTKNASE.
PROSITE	PS01128. SHIKIMATE_KINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROK_BARHE

Accession

Primary (citable) accession number: Q6G1N9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)