Q6G1I9 (Q6G1I9_BARQU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit B RuleBase RU003363 HAMAP MF_01898
EC=5.99.1.3 RuleBase RU003363 HAMAP MF_01898

Gene names

Name:	gyrB HAMAP MF_01898 EMBL CAF25544.1
Ordered Locus Names:	BQ00370

Organism

Bartonella quintana (strain Toulouse) (Rochalimaea quintana) [Complete proteome] [HAMAP]

Taxonomic identifier

283165 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	810 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. RuleBase RU003363 HAMAP MF_01898
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. RuleBase RU003363 SAAS SAAS002288 HAMAP MF_01898
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01898
Subcellular location	Cytoplasm By similarity HAMAP MF_01898.
Sequence similarities	Belongs to the type II topoisomerase family. HAMAP MF_01898 RuleBase RU000380 Contains 1 Toprim domain. SAAS SAAS002288 HAMAP MF_01898

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_01898
Ligand	ATP-binding SAAS SAAS002288 HAMAP MF_01898 RuleBase RU000380 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS002288 HAMAP MF_01898 RuleBase RU000380
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6G1I9 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: AA1D9B5E9A8D2610	FASTA	810	89,641
	10 20 30 40 50 60 MSNEITSPIN GNDYDAASIK VLKGLDAVRK RPGMYIGDTD DGSGLHHMVY EVVDNAIDEA 70 80 90 100 110 120 LAGHATLVNV TLHTDGSCSV RDNGRGIPTD IHPTEGISAA EVIMTQLHAG GKFDQNSYKV 130 140 150 160 170 180 SGGLHGVGVS VVNALSVWLQ LRIKRNGKIH EMSFTHGVAD SPLKTVGDCD AENGTEIRFL 190 200 210 220 230 240 PSSETFTMVE FDFETLERRL RELAFLNSGV HILLVDQRHA DVRSVELHYE GGLTEFVKYI 250 260 270 280 290 300 DQSKKALLDC PIYIASVKDG VSVDVALWWN DSYHEKVLCF TNNIPQRDGG THLVGFRSAL 310 320 330 340 350 360 TRQINGYAES SGIAKKEKIN LTGDDCREGL TAILSVKVPD PKFSSQTKDK LVSSEVRPIV 370 380 390 400 410 420 ENLVNEGLSA WLEEHPSEAK IVTSKVVEAA TAREAARKAR ELTRRKGALD ITSLPGKLAD 430 440 450 460 470 480 CQERDPAKSE IFIVEGDSAG GSAKSGRSRQ NQAILPLRGK ILNVERARFD RMLSSDMIGT 490 500 510 520 530 540 LITALGTSIG KDEFSPDKLR YHKIIIMTDA DVDGAHIRTL LLTFFFRQMP ELIERGHLYI 550 560 570 580 590 600 AQPPLYKVAR GKSFQYIKNE AAFEEFLIDT GLEETTLELS TGEIRAGADL RQLAEDARML 610 620 630 640 650 660 RQLLNGLHTR YNRNIIEQAA IVGAFNPQAF ATPERAQKTA DNIASRLDLI ADDMERGWSG 670 680 690 700 710 720 QCTSDGSLWF ERILRGVKDV ITLDARLINS ADARQIDRVS QNLMEIYSSP PLLHRKDKSE 730 740 750 760 770 780 QIFGPMNLLE SIFTNGKRGI TLQRYKGLGE MNAEQLWETT LNPDARALLQ VKINDATDAD 790 800 810 LLFSRLMGDE VEPRRAFIKD NALSVANLDI

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Toulouse.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897700 Genomic DNA. Translation: CAF25544.1.
RefSeq	YP_031763.1. NC_005955.1.
3D structure databases
ProteinModelPortal	Q6G1I9.
SMR	Q6G1I9. Positions 19-388.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2867167.
GenomeReviews	Gene locus BQ00370 in contig BX897700_GR.
KEGG	bqu:BQ00370.
NMPDR	fig|283165.1.peg.33.
PATRIC	31951201. VBIBarQui58630_0044.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG304889.
OMA	DCSSRDP.
PhylomeDB	Q6G1I9.
ProtClustDB	PRK14939.
Family and domain databases
HAMAP	MF_01898. GyrB. [Tree]
InterPro	IPR003594. ATPase-like_ATP-bd. IPR011557. GyrB. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR001241. Topo_IIA. IPR013759. Topo_IIA_B/N_ab. IPR002288. Topo_IIA_B_C. IPR013506. Topo_IIA_bsu_dom2. IPR013760. Topo_IIA_cen. IPR018522. TopoIIA_CS. IPR006171. Toprim_domain. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit. G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. G3DSA:3.40.50.670. Topo_IIA_B/N_ab. 2 hits.
KO	K02470.
Pfam	PF00204. DNA_gyraseB. 1 hit. PF00986. DNA_gyraseB_C. 1 hit. PF02518. HATPase_c. 1 hit. PF01751. Toprim. 1 hit. [Graphical view]
PRINTS	PR00418. TPI2FAMILY.
SMART	SM00387. HATPase_c. 1 hit. SM00433. TOP2c. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01059. GyrB. 1 hit.
PROSITE	PS00177. TOPOISOMERASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6G1I9_BARQU

Accession

Primary (citable) accession number: Q6G1I9

Entry history

Integrated into UniProtKB/TrEMBL:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)