Reviewed, UniProtKB/Swiss-Prot Q6G1H5 (AROK_BARQU)

Names and origin

Protein names

Recommended name:
    Shikimate kinase
      Short name=SK
    EC=2.7.1.71

Gene names

Name:	aroK
Ordered Locus Names:	BQ13270

Organism

Bartonella quintana (Rochalimaea quintana) [Complete proteome] [HAMAP]

Taxonomic identifier

803 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity. HAMAP MF_00109
Catalytic activity	ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP MF_00109
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00109
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP MF_00109
Subunit structure	Monomer By similarity. HAMAP MF_00109
Subcellular location	Cytoplasm Probable HAMAP MF_00109.
Sequence similarities	Belongs to the shikimate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP shikimate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Shikimate kinase HAMAP MF_00109		PRO_0000237846
Regions
	Nucleotide binding	34 – 39	6	ATP By similarity
Sites
	Metal binding	38	1	Magnesium By similarity
	Binding site	56	1	Substrate By similarity
	Binding site	80	1	Substrate By similarity
	Binding site	102	1	Substrate; via amide nitrogen By similarity
	Binding site	140	1	ATP By similarity
	Binding site	159	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6G1H5-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: CED845D884621913	FASTA	210	23,975
	10 20 30 40 50 60 MKTNHPKHIP ITQIKKQLLS SLDKRALVLV GLMGAGKSVI GKRIATMLGL PFYDSDQEIE 70 80 90 100 110 120 KAAQMTITEF FKVYGESEFR ALEQHVTLSL MKKSPLVLAT GGGAYINEDI RQVINKNGIS 130 140 150 160 170 180 IWLKADLDIL MKRVSRHPTR PLLQTANPKE TMKKLMEQRY PIYAKANLTI NSYKESRHTV 190 200 210 AQNVIRSVQN YIYTEINDRN NQHANQDRHC

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Toulouse.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897700 Genomic DNA. Translation: CAF26785.1.
RefSeq	YP_032841.1.
3D structure databases
SMR	Q6G1H5. Positions 23-172, 27-198.
ModBase	Search...
Genome annotation databases
GeneID	2867082.
GenomeReviews	Gene locus BQ13270 in contig BX897700_GR.
KEGG	bqu:BQ13270.
NMPDR	fig|283165.1.peg.1111.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG335815.
OMA	HANVFFV.
PhylomeDB	Q6G1H5.
Enzyme and pathway databases
BioCyc	BQUI283165:BQ13270-MONOMER.
BRENDA	2.7.1.71. 292235.
Family and domain databases
HAMAP	MF_00109. Shikimate_kinase. [Tree]
InterPro	IPR000623. Shik_kinase. [Graphical view]
Pfam	PF01202. SKI. 1 hit. [Graphical view]
PRINTS	PR01100. SHIKIMTKNASE.
PROSITE	PS01128. SHIKIMATE_KINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROK_BARQU

Accession

Primary (citable) accession number: Q6G1H5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	July 19, 2004
Last modified:	January 19, 2010
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)