Reviewed, UniProtKB/Swiss-Prot Q6G1H4 (AROB_BARQU)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	BQ13280

Organism

Bartonella quintana (Rochalimaea quintana) [Complete proteome] [HAMAP]

Taxonomic identifier

803 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. HAMAP MF_00110 NAD By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm Probable HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 377	377	3-dehydroquinate synthase HAMAP MF_00110		PRO_0000231069

Sequences

	Sequence		Length	Mass (Da)
	Q6G1H4-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: A4C20353D56ED095	FASTA	377	41,592
	10 20 30 40 50 60 MQTKTVTVKL DKHCYDIIIG PGLVAQAVWQ IKHSLHKKDL HQTRFALVTD SNVASLHLDT 70 80 90 100 110 120 LQAELTKNKI HTVPIIVEAG EQSKSFLTLQ IVIDRILAAR LERGDCVIAF GGGVIGDLGG 130 140 150 160 170 180 FAASIIRRGM NFIQMPTTLL AQIDSSVGGK TGINSRYGKN LIGAFYQPQC VIADTCFLDT 190 200 210 220 230 240 LPLREFRAGY AEIVKYGLIS QPDFFEWLEK NWQKIFSNGP TRTEAIVRSC QFKADIVARD 250 260 270 280 290 300 EHETGERALL NLGHTFGHML ETATAYDSNR LIHGEAVAIG MVLAHQFSAQ LNLINPTLIQ 310 320 330 340 350 360 RVEAHLKAVG LPTQLKDIPG KLPEAETLMT LIAQDKKVSQ NNLTFILTRG LGQSFIAKTV 370 SPEAVLAFLE QKLAEIR

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Toulouse.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897700 Genomic DNA. Translation: CAF26786.1.
RefSeq	YP_032842.1.
3D structure databases
SMR	Q6G1H4. Positions 10-368.
ModBase	Search...
Genome annotation databases
GeneID	2867442.
GenomeReviews	Gene locus BQ13280 in contig BX897700_GR.
KEGG	bqu:BQ13280.
NMPDR	fig|283165.1.peg.1112.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG632303.
OMA	NHLADKG.
PhylomeDB	Q6G1H4.
Enzyme and pathway databases
BioCyc	BQUI283165:BQ13280-MONOMER.
BRENDA	4.2.3.4. 292235.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_BARQU

Accession

Primary (citable) accession number: Q6G1H4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)