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Protein

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Gene

dapD

Organism
Bartonella quintana (strain Toulouse) (Rochalimaea quintana)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.UniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (dapD)
  2. no protein annotated in this organism
  3. Succinyl-diaminopimelate desuccinylase (dapE)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109SubstrateUniRule annotation1
Binding sitei146SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciBQUI283165:G1GJ6-67-MONOMER.
UniPathwayiUPA00034; UER00019.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseUniRule annotation (EC:2.3.1.117UniRule annotation)
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferaseUniRule annotation
Short name:
THDP succinyltransferaseUniRule annotation
Short name:
THP succinyltransferaseUniRule annotation
Short name:
Tetrahydropicolinate succinylaseUniRule annotation
Gene namesi
Name:dapDUniRule annotation
Ordered Locus Names:BQ00650
OrganismiBartonella quintana (strain Toulouse) (Rochalimaea quintana)
Taxonomic identifieri283165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000597 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001969141 – 2822,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseAdd BLAST282

Proteomic databases

PRIDEiQ6G1F4.

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi283165.BQ00650.

Structurei

3D structure databases

ProteinModelPortaliQ6G1F4.
SMRiQ6G1F4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105DMJ. Bacteria.
COG2171. LUCA.
HOGENOMiHOG000003295.
KOiK00674.
OMAiQVPCALI.
OrthoDBiPOG091H0G02.

Family and domain databases

Gene3Di1.10.166.10. 1 hit.
HAMAPiMF_00811. DapD. 1 hit.
InterProiView protein in InterPro
IPR005664. DapD_Trfase_Hexpep_rpt_fam.
IPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR023180. THP_succinylTrfase_dom1.
IPR037133. THP_succinylTrfase_N_sf.
IPR011004. Trimer_LpxA-like_sf.
PfamiView protein in Pfam
PF00132. Hexapep. 1 hit.
PF14602. Hexapep_2. 1 hit.
PF14805. THDPS_N_2. 1 hit.
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR00965. dapD. 1 hit.
PROSITEiView protein in PROSITE
PS00101. HEXAPEP_TRANSFERASES. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6G1F4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNLTQLEMI IEKAFDDRDS IKTTTKGEIR ESVEHALNLL DKGEIRVAER
60 70 80 90 100
QKNGQWHVHQ WLKKAVLLFF RLNPMQIIAG GVNGTYWWDK VPSKFSNWQE
110 120 130 140 150
TDFKKANFRS VPGTIVRHSA YIAPNVILMP SFVNLGAFID EGTMVDTWAT
160 170 180 190 200
VGSCAQIGKH VHLSGGVGLG GVLEPLQANP TIIEDHCFIG ARSEVVEGCI
210 220 230 240 250
IREGAVLGMG VFIGKSTKII DRTTGEVFIG EVPAYSVVVP GSLPGKPLPN
260 270 280
GEVGPNLYCA VIVKRVDQKT REKTSINDLL RD
Length:282
Mass (Da):31,051
Last modified:July 19, 2004 - v1
Checksum:i2FFC9BBF46341176
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897700 Genomic DNA. Translation: CAF25572.1.
RefSeqiWP_011178899.1. NC_005955.1.

Genome annotation databases

EnsemblBacteriaiCAF25572; CAF25572; BQ00650.
GeneIDi34145380.
KEGGibqu:BQ00650.

Similar proteinsi

Entry informationi

Entry nameiDAPD_BARQU
AccessioniPrimary (citable) accession number: Q6G1F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2004
Last modified: February 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome