Reviewed, UniProtKB/Swiss-Prot Q6G1E6 (NTPA_BARQU)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

BQ00480

Organism

Bartonella quintana (Rochalimaea quintana) [Complete proteome] [HAMAP]

Taxonomic identifier

803 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate. HAMAP MF_01405
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 215	215	Nucleoside-triphosphatase HAMAP MF_01405		PRO_0000178132

Sequences

	Sequence		Length	Mass (Da)
	Q6G1E6-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 982871F8EDDF3570	FASTA	215	23,668
	10 20 30 40 50 60 MRSIASKKLV IATHNTGKLH EITTLVAPFG LEIQSAKELD LPEPKETGVT FEENAYIKAF 70 80 90 100 110 120 AAAKNTGLPA LSDDSGLEVD ALGGAPGVYT ADWALQSDGT RNFSKAMQKI EDELQKIGAH 130 140 150 160 170 180 EKSQRKARFI SVICIAWSDA YADYFRGSVE GTFIWPPRGD KGFGFDPIFL PDGYENTFGE 190 200 210 MSTEQKHGWK LNDKTPLSHR ARAFKLLAEN LLTLS

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Toulouse.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX897700 Genomic DNA. Translation: CAF25555.1.
RefSeq	YP_031774.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2866883.
GenomeReviews	Gene locus BQ00480 in contig BX897700_GR.
KEGG	bqu:BQ00480.
NMPDR	fig|283165.1.peg.44.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6G1E6.
OMA	Q6G1E6. VYTADWA.
Enzyme and pathway databases
BioCyc	BQUI283165:BQ00480-MON.
BRENDA	3.6.1.15. 292235.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p-like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_BARQU

Accession

Primary (citable) accession number: Q6G1E6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	July 19, 2004
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)