Reviewed, UniProtKB/Swiss-Prot Q6G1B5 (AROE_BARQU)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	BQ00030

Organism

Bartonella quintana (Rochalimaea quintana) [Complete proteome] [HAMAP]

Taxonomic identifier

803 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325104
Regions
	Nucleotide binding	137 – 141	5	NADP By similarity
Sites
	Active site	77	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6G1B5-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 1802ED4064E6F188	FASTA	293	32,783
	10 20 30 40 50 60 MIDLTIKCKE KVPSRAFVVG YPIHHSKSPK IHNFWLKQYG LQGEYLAQEV KLEEFSDFLT 70 80 90 100 110 120 STKKRGFCGG NVTLPYKQEA FRLANYKDEV ATMIGAANTL WYEGDKLCAT NSDAYGFSAN 130 140 150 160 170 180 LDDSAPNWVG ETALIFGAGG AARAILYALK KRGFERICLL NRTRQRADNL AEHFGKPVEV 190 200 210 220 230 240 HDWHNVGEIL YEADLIVNTT SVGMTDPHGW KTGSLFCDFQ KTKTTTLVTD IVYTPLTTPF 250 260 270 280 290 LQQAKAHGLR TVDGLGMLLH QAVPGFERWF GITPQVTKAL RTKILEDMGE ERG

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Toulouse.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897700 Genomic DNA. Translation: CAF25510.1.
RefSeq	YP_031733.1.
3D structure databases
HSSP	HSSP built from PDB template 1P77 based on UniProtKB P43876.
SMR	Q6G1B5. Positions 15-286.
ModBase	Search...
Genome annotation databases
GeneID	2867106.
GenomeReviews	Gene locus BQ00030 in contig BX897700_GR.
KEGG	bqu:BQ00030.
NMPDR	fig|283165.1.peg.3.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553408.
OMA	PLMHHAN.
PhylomeDB	Q6G1B5.
Enzyme and pathway databases
BioCyc	BQUI283165:BQ00030-MONOMER.
BRENDA	1.1.1.25. 292235.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_BARQU

Accession

Primary (citable) accession number: Q6G1B5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)