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Protein

Shikimate dehydrogenase (NADP(+))

Gene

aroE

Organism
Bartonella quintana (strain Toulouse) (Rochalimaea quintana)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).UniRule annotation

Catalytic activityi

Shikimate + NADP+ = 3-dehydroshikimate + NADPH.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73ShikimateUniRule annotation1
Active sitei77Proton acceptorUniRule annotation1
Binding sitei89NADPUniRule annotation1
Binding sitei98ShikimateUniRule annotation1
Binding sitei113ShikimateUniRule annotation1
Binding sitei231NADP; via carbonyl oxygenUniRule annotation1
Binding sitei233ShikimateUniRule annotation1
Binding sitei254NADP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi137 – 141NADPUniRule annotation5
Nucleotide bindingi161 – 166NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00053; UER00087

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate dehydrogenase (NADP(+))UniRule annotation (EC:1.1.1.25UniRule annotation)
Short name:
SDHUniRule annotation
Gene namesi
Name:aroEUniRule annotation
Ordered Locus Names:BQ00030
OrganismiBartonella quintana (strain Toulouse) (Rochalimaea quintana)
Taxonomic identifieri283165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000597 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003251041 – 293Shikimate dehydrogenase (NADP(+))Add BLAST293

Proteomic databases

PRIDEiQ6G1B5

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi283165.BQ00030

Structurei

3D structure databases

ProteinModelPortaliQ6G1B5
SMRiQ6G1B5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 28Shikimate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the shikimate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2X Bacteria
COG0169 LUCA
HOGENOMiHOG000237875
KOiK00014
OMAiFGNPIKH
OrthoDBiPOG091H02DY

Family and domain databases

HAMAPiMF_00222 Shikimate_DH_AroE, 1 hit
InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR011342 Shikimate_DH
IPR013708 Shikimate_DH-bd_N
IPR022893 Shikimate_DH_fam
IPR006151 Shikm_DH/Glu-tRNA_Rdtase
PfamiView protein in Pfam
PF01488 Shikimate_DH, 1 hit
PF08501 Shikimate_dh_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00507 aroE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6G1B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDLTIKCKE KVPSRAFVVG YPIHHSKSPK IHNFWLKQYG LQGEYLAQEV
60 70 80 90 100
KLEEFSDFLT STKKRGFCGG NVTLPYKQEA FRLANYKDEV ATMIGAANTL
110 120 130 140 150
WYEGDKLCAT NSDAYGFSAN LDDSAPNWVG ETALIFGAGG AARAILYALK
160 170 180 190 200
KRGFERICLL NRTRQRADNL AEHFGKPVEV HDWHNVGEIL YEADLIVNTT
210 220 230 240 250
SVGMTDPHGW KTGSLFCDFQ KTKTTTLVTD IVYTPLTTPF LQQAKAHGLR
260 270 280 290
TVDGLGMLLH QAVPGFERWF GITPQVTKAL RTKILEDMGE ERG
Length:293
Mass (Da):32,783
Last modified:July 19, 2004 - v1
Checksum:i1802ED4064E6F188
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897700 Genomic DNA Translation: CAF25510.1
RefSeqiWP_011178842.1, NC_005955.1

Genome annotation databases

EnsemblBacteriaiCAF25510; CAF25510; BQ00030
GeneIDi34145367
KEGGibqu:BQ00030

Similar proteinsi

Entry informationi

Entry nameiAROE_BARQU
AccessioniPrimary (citable) accession number: Q6G1B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 19, 2004
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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