Reviewed, UniProtKB/Swiss-Prot Q6G125 (MURC_BARQU)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylmuramate--L-alanine ligase
    EC=6.3.2.8
Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanine synthetase

Gene names

Name:	murC
Ordered Locus Names:	BQ08850

Organism

Bartonella quintana (Rochalimaea quintana) [Complete proteome] [HAMAP]

Taxonomic identifier

803 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	475 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cell wall formation By similarity.
Catalytic activity	ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the murCDEF family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP UDP-N-acetylmuramate-L-alanine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 475	475	UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046		PRO_0000182057
Regions
	Nucleotide binding	114 – 120	7	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6G125-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: BB1F3FD4F81443C3	FASTA	475	52,116
	10 20 30 40 50 60 MKMPFNIGLI HFVGVGGIGM SGIAEVFHNL GYKVQGSDHV DSANVERLRG KGINIQIGHH 70 80 90 100 110 120 AENLGDAEVV VLSTAIKKTN PEYIAAKEKH LPIVRRAEML AELMRFRRAI AVGGTHGKTT 130 140 150 160 170 180 TTSMIAALLD AGRFDPMVIN GGIINAYGTN ARMGSGDWMV VEADESDGTF LKLPADIAVV 190 200 210 220 230 240 TNIDREHLDH YGSFCAVREA FRQFVENVPF YGFAVLCLDH PEVQSLASRI DDRWVITYGT 250 260 270 280 290 300 NPQADIRFLN LSMDGQKTHF DVFIRSRKTG KETELKNLVL PMSGQHNVSN ATAAIAIAHE 310 320 330 340 350 360 LGISNESIKK GLAEFGGVKR RFTQTGSWRG IEIFDDYGHH PVEIKAVLYA ARESAKGRVI 370 380 390 400 410 420 AIVQPHRYSR LYHLFDDFAA CFNDADTVLI APIYGAGEAP IAGFGARELV EHIKMAGHRD 430 440 450 460 470 VRLIHCLEDV VLIVSTFAKP GDYVVFLGAG NITQWAAALP HQLAVLDNND EFSVD

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Toulouse.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX897700 Genomic DNA. Translation: CAF26364.1.
RefSeq	YP_032497.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2866914.
GenomeReviews	Gene locus BQ08850 in contig BX897700_GR.
KEGG	bqu:BQ08850.
NMPDR	fig|283165.1.peg.767.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6G125.
OMA	EWMVVEA.
Enzyme and pathway databases
BioCyc	BQUI283165:BQ08850-MON.
BRENDA	6.3.2.8. 292235.
Family and domain databases
HAMAP	MF_00046. [Tree]
InterPro	IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR016040. NAD(P)-bd_dom. IPR005758. UDP-N-AcMur_Ala_ligase. [Graphical view]
Gene3D	G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view]
TIGRFAMs	TIGR01082. murC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURC_BARQU

Accession

Primary (citable) accession number: Q6G125

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)