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Q6G124 (MURG_BARQU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:BQ08860
OrganismBartonella quintana (strain Toulouse) (Rochalimaea quintana) [Complete proteome] [HAMAP]
Taxonomic identifier283165 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP MF_00033
PRO_0000315070

Sequences

Sequence LengthMass (Da)Tools
Q6G124 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 557538FD71025445

FASTA37841,289
        10         20         30         40         50         60 
MAHKKVIVLV AGGTGGHLFP AEAVAVELRQ RGYDVHLVTD RRAKCFVSCV DEEHTHIVSS 

        70         80         90        100        110        120 
ATFTRRHPFA LIKTCWILLK GMGQSLALFY KLRPVLVGGF GGYPTFPPLL VAALMRCVTF 

       130        140        150        160        170        180 
IHEQNAIMGR ANRVLAVFVH AIAGGLLSQT GTHAHKTLLI GNPMREVVLK AAKIPYRPSL 

       190        200        210        220        230        240 
GEKPFHFLVF GGSQGASFFS RIVPEAIALL NNKIRRRLRI IQQVRGEVVE LMKTYRSMGV 

       250        260        270        280        290        300 
QAEVAPFFND MAERMAHAHF ILSRAGASSV CEIAVIGRPA LLIPYPYALD HDQAANAALL 

       310        320        330        340        350        360 
ARVGGAQIVS EKDLTAQRLA SLLTQACCAP HLLEKQALAA KKVGQPYATR RLADMAEALI 

       370 
AGRSLSDVRE EFFDENAV

« Hide

References

[1]"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae."
Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E.
Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Toulouse.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX897700 Genomic DNA. Translation: CAF26365.1.
RefSeqYP_032498.1. NC_005955.1.

3D structure databases

HSSPHSSP built from PDB template 1F0K based on UniProtKB P17443.
ProteinModelPortalQ6G124.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2866590.
GenomeReviewsGene locus BQ08860 in contig BX897700_GR.
KEGGbqu:BQ08860.
NMPDRfig|283165.1.peg.768.
PATRIC31953093. VBIBarQui58630_0962.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG617076.
OMAEDHQTKN.
PhylomeDBQ6G124.
ProtClustDBPRK00726.

Enzyme and pathway databases

BioCycBQUI283165:BQ08860-MONOMER.

Family and domain databases

HAMAPMF_00033. MurG.
[Tree]
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
KOK02563.
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. MurG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG_BARQU
AccessionPrimary (citable) accession number: Q6G124
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 19, 2004
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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