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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Bartonella quintana (strain Toulouse) (Rochalimaea quintana)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBQUI283165:GHZA-885-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:BQ08860
OrganismiBartonella quintana (strain Toulouse) (Rochalimaea quintana)
Taxonomic identifieri283165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000597 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferasePRO_0000315070Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi283165.BQ08860.

Structurei

3D structure databases

ProteinModelPortaliQ6G124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVQ. Bacteria.
COG0707. LUCA.
HOGENOMiHOG000218321.
KOiK02563.
OMAiEQNALPG.
OrthoDBiEOG61VZFD.

Family and domain databases

HAMAPiMF_00033. MurG.
InterProiIPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6G124-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHKKVIVLV AGGTGGHLFP AEAVAVELRQ RGYDVHLVTD RRAKCFVSCV
60 70 80 90 100
DEEHTHIVSS ATFTRRHPFA LIKTCWILLK GMGQSLALFY KLRPVLVGGF
110 120 130 140 150
GGYPTFPPLL VAALMRCVTF IHEQNAIMGR ANRVLAVFVH AIAGGLLSQT
160 170 180 190 200
GTHAHKTLLI GNPMREVVLK AAKIPYRPSL GEKPFHFLVF GGSQGASFFS
210 220 230 240 250
RIVPEAIALL NNKIRRRLRI IQQVRGEVVE LMKTYRSMGV QAEVAPFFND
260 270 280 290 300
MAERMAHAHF ILSRAGASSV CEIAVIGRPA LLIPYPYALD HDQAANAALL
310 320 330 340 350
ARVGGAQIVS EKDLTAQRLA SLLTQACCAP HLLEKQALAA KKVGQPYATR
360 370
RLADMAEALI AGRSLSDVRE EFFDENAV
Length:378
Mass (Da):41,289
Last modified:July 19, 2004 - v1
Checksum:i557538FD71025445
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897700 Genomic DNA. Translation: CAF26365.1.
RefSeqiWP_011179603.1. NC_005955.1.

Genome annotation databases

EnsemblBacteriaiCAF26365; CAF26365; BQ08860.
KEGGibqu:BQ08860.
PATRICi31953093. VBIBarQui58630_0962.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897700 Genomic DNA. Translation: CAF26365.1.
RefSeqiWP_011179603.1. NC_005955.1.

3D structure databases

ProteinModelPortaliQ6G124.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283165.BQ08860.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF26365; CAF26365; BQ08860.
KEGGibqu:BQ08860.
PATRICi31953093. VBIBarQui58630_0962.

Phylogenomic databases

eggNOGiENOG4105DVQ. Bacteria.
COG0707. LUCA.
HOGENOMiHOG000218321.
KOiK02563.
OMAiEQNALPG.
OrthoDBiEOG61VZFD.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciBQUI283165:GHZA-885-MONOMER.

Family and domain databases

HAMAPiMF_00033. MurG.
InterProiIPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Toulouse.

Entry informationi

Entry nameiMURG_BARQU
AccessioniPrimary (citable) accession number: Q6G124
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 19, 2004
Last modified: November 11, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.