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Q6G0X7

- PNCB_BARQU

UniProt

Q6G0X7 - PNCB_BARQU

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Bartonella quintana (strain Toulouse) (Rochalimaea quintana)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciBQUI283165:GHZA-84-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:BQ00840
    OrganismiBartonella quintana (strain Toulouse) (Rochalimaea quintana)
    Taxonomic identifieri283165 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
    ProteomesiUP000000597: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Nicotinate phosphoribosyltransferasePRO_1000146830Add
    BLAST

    Proteomic databases

    PRIDEiQ6G0X7.

    Interactioni

    Protein-protein interaction databases

    STRINGi283165.BQ00840.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6G0X7.
    SMRiQ6G0X7. Positions 1-426.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284929.
    KOiK00763.
    OMAiQAVFHRY.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6G0X7-1 [UniParc]FASTAAdd to Basket

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    MNHPDIAQRV YNHTWKLDPI IRSLLDTDFY KLLMLQMIWG LYPNVNVTFT    50
    LINRTKTIRL ADDIDEGELR AQLDHALSLR FTKKEMIWLA GNTFYGRKQI 100
    FKPDFLHWLK NFQLPEYELT RKDGQYILHF HGPWSHSSMW EIPALAIISE 150
    LRSRAAMKNL DRFALDVLYA RAKAKMWSKV EQLKKLPDIK ISDFGTRRRH 200
    SFLWQRWCVE ALKEGIGDSF TGTSNVLLAM ATDLEALGTN AHELPMVIAA 250
    LTNNDNELCK APYQVLQDWN RYYGGNLLIV LPDTFGTETF LRNAPDWVAD 300
    WTGFRPDSAP PIEGGERIIQ WWKEKGKDPR EKLLIFSDAL DVNTIEQTYH 350
    HFHGRVRMSF GWGTDLTNDF VGCAPQKIAT FDALSLVCKV THANGRPAVK 400
    LSDNPEKTIG DPREIQRYLN FFGNENFITR PINT 434
    Length:434
    Mass (Da):50,232
    Last modified:July 19, 2004 - v1
    Checksum:iC33286B699BD576C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX897700 Genomic DNA. Translation: CAF25591.1.
    RefSeqiYP_031809.1. NC_005955.1.

    Genome annotation databases

    EnsemblBacteriaiCAF25591; CAF25591; BQ00840.
    GeneIDi2866635.
    KEGGibqu:BQ00840.
    PATRICi31951301. VBIBarQui58630_0094.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX897700 Genomic DNA. Translation: CAF25591.1 .
    RefSeqi YP_031809.1. NC_005955.1.

    3D structure databases

    ProteinModelPortali Q6G0X7.
    SMRi Q6G0X7. Positions 1-426.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 283165.BQ00840.

    Proteomic databases

    PRIDEi Q6G0X7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF25591 ; CAF25591 ; BQ00840 .
    GeneIDi 2866635.
    KEGGi bqu:BQ00840.
    PATRICi 31951301. VBIBarQui58630_0094.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284929.
    KOi K00763.
    OMAi QAVFHRY.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci BQUI283165:GHZA-84-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Toulouse.

    Entry informationi

    Entry nameiPNCB_BARQU
    AccessioniPrimary (citable) accession number: Q6G0X7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3