Q6G0X7 (PNCB_BARQU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinate phosphoribosyltransferase
Short name=NAPRTase
EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	BQ00840

Organism

Bartonella quintana (strain Toulouse) (Rochalimaea quintana) [Complete proteome] [HAMAP]

Taxonomic identifier

283165 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP MF_00570
Subcellular location	Cytoplasm By similarity HAMAP MF_00570.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: InterPro nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC nicotinate-nucleotide diphosphorylase (carboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	Nicotinate phosphoribosyltransferase HAMAP MF_00570		PRO_1000146830

Sequences

	Sequence		Length	Mass (Da)
	Q6G0X7 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: C33286B699BD576C	FASTA	434	50,232
	10 20 30 40 50 60 MNHPDIAQRV YNHTWKLDPI IRSLLDTDFY KLLMLQMIWG LYPNVNVTFT LINRTKTIRL 70 80 90 100 110 120 ADDIDEGELR AQLDHALSLR FTKKEMIWLA GNTFYGRKQI FKPDFLHWLK NFQLPEYELT 130 140 150 160 170 180 RKDGQYILHF HGPWSHSSMW EIPALAIISE LRSRAAMKNL DRFALDVLYA RAKAKMWSKV 190 200 210 220 230 240 EQLKKLPDIK ISDFGTRRRH SFLWQRWCVE ALKEGIGDSF TGTSNVLLAM ATDLEALGTN 250 260 270 280 290 300 AHELPMVIAA LTNNDNELCK APYQVLQDWN RYYGGNLLIV LPDTFGTETF LRNAPDWVAD 310 320 330 340 350 360 WTGFRPDSAP PIEGGERIIQ WWKEKGKDPR EKLLIFSDAL DVNTIEQTYH HFHGRVRMSF 370 380 390 400 410 420 GWGTDLTNDF VGCAPQKIAT FDALSLVCKV THANGRPAVK LSDNPEKTIG DPREIQRYLN 430 FFGNENFITR PINT

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Toulouse.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897700 Genomic DNA. Translation: CAF25591.1.
RefSeq	YP_031809.1. NC_005955.1.
3D structure databases
HSSP	HSSP built from PDB template 1YBE based on UniProtKB Q8UIS9.
ProteinModelPortal	Q6G0X7.
SMR	Q6G0X7. Positions 1-426.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2866635.
GenomeReviews	Gene locus BQ00840 in contig BX897700_GR.
KEGG	bqu:BQ00840.
NMPDR	fig|283165.1.peg.79.
PATRIC	31951301. VBIBarQui58630_0094.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG325503.
OMA	HQFPQTH.
PhylomeDB	Q6G0X7.
ProtClustDB	PRK05321.
Enzyme and pathway databases
BioCyc	BQUI283165:BQ00840-MONOMER.
Family and domain databases
HAMAP	MF_00570. NAPRTase. [Tree]
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR002638. Quinolinate_PRibosylTrfase_C. [Graphical view]
KO	K00763.
PANTHER	PTHR11098:SF1. NAPRTase. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
SUPFAM	SSF51690. Q_phspho_trans. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_BARQU

Accession

Primary (citable) accession number: Q6G0X7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program