Reviewed, UniProtKB/Swiss-Prot Q6G0X3 (AROA_BARQU)

Names and origin

Protein names

Recommended name:
    3-phosphoshikimate 1-carboxyvinyltransferase
    EC=2.5.1.19
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthase
      Short name=EPSP synthase
      Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	BQ00880

Organism

Bartonella quintana (Rochalimaea quintana) [Complete proteome] [HAMAP]

Taxonomic identifier

803 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_0000325335

Sequences

	Sequence		Length	Mass (Da)
	Q6G0X3-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 225F15BCFDF6DBBA	FASTA	442	47,538
	10 20 30 40 50 60 MQKTTPITAY KSTCLSGKIK IPGDKSISHR SLILGGLANG ETHIHGLLES DDVLNTAAAM 70 80 90 100 110 120 QAMGACIIKK ADRWIIRGTG NGCLLAAEKP LNFGNAGTGA RLVMGMVGPY HMKTTFIGDA 130 140 150 160 170 180 SLSKRPMGRI LNPLRLMGVE IEATHGDRLP LTLYGPKMAN PIRYRIPIAS AQVKSAILLA 190 200 210 220 230 240 GLNTAGTTTV IEPILTRDHT EKMLKAFGAE LEIKTDAEGT RFIHLNGQPH LTGQTIHIPG 250 260 270 280 290 300 DPSSAAFPII AALLVENSDI TIENVLINKS RMGLIETLWE MDAKIELLNQ HKTGGENVAD 310 320 330 340 350 360 LRVKSSMLKG VTVPKERAPS MIDEYPALAV AAAFAEGKTV MLGIDELRVK ESDRLSALAQ 370 380 390 400 410 420 GLKINHVDCE EGKDFLIVHG KSSAKGLGGG HVTTHLDHRI AMSFLIFGLV SEKPVTIDDK 430 440 RMIATSFPEF IPFIQQLGGK IS

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Toulouse.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX897700 Genomic DNA. Translation: CAF25595.1.
RefSeq	YP_031813.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2866984.
GenomeReviews	Gene locus BQ00880 in contig BX897700_GR.
KEGG	bqu:BQ00880.
NMPDR	fig|283165.1.peg.83.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6G0X3.
OMA	NPTRIEA.
Enzyme and pathway databases
BioCyc	BQUI283165:BQ00880-MON.
BRENDA	2.5.1.19. 292235.
Family and domain databases
HAMAP	MF_00210. [Tree]
InterPro	IPR016228. EPSP_synthase. IPR001986. EPSP_synthase_core. IPR006264. EPSP_synthase_subgroup. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
ProDom	PD001867. EPSP_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01356. aroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_BARQU

Accession

Primary (citable) accession number: Q6G0X3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)