Reviewed, UniProtKB/Swiss-Prot Q6G0S6 (PROA_BARQU)

Names and origin

Protein names

Recommended name:
    Gamma-glutamyl phosphate reductase
      Short name=GPR
    EC=1.2.1.41
Alternative name(s):
    Glutamate-5-semialdehyde dehydrogenase
    Glutamyl-gamma-semialdehyde dehydrogenase
      Short name=GSA dehydrogenase

Gene names

Name:	proA
Ordered Locus Names:	BQ01480

Organism

Bartonella quintana (Rochalimaea quintana) [Complete proteome] [HAMAP]

Taxonomic identifier

803 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	412 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. HAMAP MF_00412
Catalytic activity	L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro glutamate-5-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 412	412	Gamma-glutamyl phosphate reductase HAMAP MF_00412		PRO_0000189699

Sequences

	Sequence		Length	Mass (Da)
	Q6G0S6-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 7E460291E742A82F	FASTA	412	44,633
	10 20 30 40 50 60 MKDMGQKARH AAALLAVMSS EQKNKALEMI ALSLEAQSAE ILQANHQDLV NAAQNNLNVA 70 80 90 100 110 120 MVDRLKLDKV RLCTIIDSVR QVACLPDPVG QVMSEWTRPN GLHIRRVRTP LGVIGIIYES 130 140 150 160 170 180 RPSVTIDASI LCLKSGNAAI LRGGSDSFHS AHALHSALVK GLKEAGLPQD AIQMVGTKDR 190 200 210 220 230 240 DVVGEMLKGL DGAIDVIVPR GGKDLVARVQ SDARVPIFAH LEGLCHIYID QSADLDMARN 250 260 270 280 290 300 IVLNAKLRRT GICGAVETVL IDRQALKKFL PVLTALQEKG CEIRATEDIV FLLPDVKLAS 310 320 330 340 350 360 EEDWSQEYLD AILSVKTVEG IEGAIAHIRR YSSGHTESII AEDMKVVKIF FNCLDSAILL 370 380 390 400 410 HNASTQFADG GEFGFGAEIG IATGKMHARG PVGVEQLTSF QYHVKGNGQV RS

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Toulouse.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX897700 Genomic DNA. Translation: CAF25651.1.
RefSeq	YP_031860.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2867258.
GenomeReviews	Gene locus BQ01480 in contig BX897700_GR.
KEGG	bqu:BQ01480.
NMPDR	fig|283165.1.peg.130.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6G0S6.
OMA	QYPAACN.
Enzyme and pathway databases
BioCyc	BQUI283165:BQ01480-MON.
BRENDA	1.2.1.41. 292235.
Family and domain databases
HAMAP	MF_00412. [Tree]
InterPro	IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR000965. G-glutamylP_reductase. IPR020593. G-glutamylP_reductase_CS. IPR012134. Glu-5-SA_DH. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11063:SF1. GSA_DH. 1 hit.
PIRSF	PIRSF000151. GPR. 1 hit.
TIGRFAMs	TIGR00407. proA. 1 hit.
PROSITE	PS01223. PROA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROA_BARQU

Accession

Primary (citable) accession number: Q6G0S6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2004
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)