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Reviewed, UniProtKB/Swiss-Prot Q6G0J2 (LLDD_BARQU)

Last modified January 19, 2010. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    L-lactate dehydrogenase [cytochrome]
    EC=1.1.2.3
Gene names
Name: lldD
Ordered Locus Names: BQ02590
OrganismBartonella quintana (Rochalimaea quintana) [Complete proteome] [HAMAP]
Taxonomic identifier803 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

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Protein attributes

Sequence length383 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+. HAMAP MF_01559

Cofactor

FMN By similarity. HAMAP MF_01559

Sequence similarities

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Contains 1 FMN hydroxy acid dehydrogenase domain.

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Ontologies

Keywords
   LigandFMN
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlactate metabolic process

Inferred from electronic annotation. Source: InterPro

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionFMN binding

Inferred from electronic annotation. Source: InterPro

L-lactate dehydrogenase (cytochrome) activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 383383L-lactate dehydrogenase [cytochrome] HAMAP MF_01559
PRO_0000206332

Regions

Domain1 – 380380FMN hydroxy acid dehydrogenase
Nucleotide binding306 – 33025FMN By similarity

Sites

Active site2751Proton acceptor By similarity
Binding site241Substrate Potential
Binding site1061FMN By similarity
Binding site1271FMN By similarity
Binding site1291Substrate By similarity
Binding site1551FMN By similarity
Binding site1641Substrate By similarity
Binding site2511FMN By similarity
Binding site2781Substrate Potential

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Sequences

Sequence LengthMass (Da)Tools
Q6G0J2-1 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 53E7E179EED53120

FASTA38342,094
        10         20         30         40         50         60 
MIISSTFDYR KAAKRRLPPF LFHYIDGGAY AEETMRRNYA DLQALALRQR ILRQVGEVDL 

        70         80         90        100        110        120 
SIKLFDQRLN LPIVLAPVGL TGMYARRGEV KAARAAVAKG IPFTLSSVSV CSLAEVHAEV 

       130        140        150        160        170        180 
GSGFWFQLYV LKDRGFMRDV LERSWLAGVR TLVFTVDMPV PGARYRDAHS GMSGPYAGLR 

       190        200        210        220        230        240 
RILQAVVHPH WAWNVGIMGR PHDLGNVSTY LQKKITLEDY VGWLGANFDP SIGWSDLQWI 

       250        260        270        280        290        300 
RDFWKGKMIL KGILDPQDAR EAVQFGADGI VVSNHGGRQL DGVLSTARAL PAIAEVVTGD 

       310        320        330        340        350        360 
LTILADSGVR SGLDVVRMIA QGADAVMIGR AFIYALAAAG EKGVMHLLDL FANEMRVAMT 

       370        380 
LTGVRAVKEI THESLASTDA LNQ

« Hide

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References

[1]"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae."
Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E.
Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Toulouse.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX897700 Genomic DNA. Translation: CAF25762.1.
RefSeqYP_031962.1.

3D structure databases

SMRQ6G0J2. Positions 4-375.
ModBaseSearch...

Genome annotation databases

GeneID2867178.
GenomeReviewsGene locus BQ02590 in contig BX897700_GR.
KEGGbqu:BQ02590.
NMPDRfig|283165.1.peg.232.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG517781.
OMANFDPSIG.
PhylomeDBQ6G0J2.

Enzyme and pathway databases

BioCycBQUI283165:BQ02590-MONOMER.
BRENDA1.1.2.3. 292235.

Family and domain databases

HAMAPMF_01559. L-lact_dehydr.
[Tree]
InterProIPR012133. a-Hydoxy_acid_DH_FMN.
IPR013785. Aldolase_TIM.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_cyt.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLLDD_BARQU
AccessionPrimary (citable) accession number: Q6G0J2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 19, 2004
Last modified: January 19, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents