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Reviewed, UniProtKB/Swiss-Prot Q6G0G3 (ISPE_BARQU)

Last modified November 3, 2009. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
      Short name=CMK
    EC=2.7.1.148
Alternative name(s):
    4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Gene names
Name: ispE
Ordered Locus Names: BQ03230
OrganismBartonella quintana (Rochalimaea quintana) [Complete proteome] [HAMAP]
Taxonomic identifier803 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity.

Catalytic activity

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00061

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP MF_00061

Sequence similarities

Belongs to the GHMP kinase family. IspE subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3023024-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP MF_00061
PRO_0000235069

Regions

Nucleotide binding106 – 11611ATP Potential

Sites

Active site201 By similarity
Active site1481 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6G0G3-1 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 43014CF1B633B526

FASTA30233,124
        10         20         30         40         50         60 
MMSDVKVSFK GHSYVFTPIK LNLTLHVVGQ RTDGYHLIES LVYFSFSGDC LSYMPCKSNH 

        70         80         90        100        110        120 
FILTGPFADE LVSDTGNLVV RAHDFMCKAF PKCAKPAFFR LVKLLPVASG IGGGSGNAAG 

       130        140        150        160        170        180 
VLSLLRQQWG LDCSCEKLAE MSLVLGADVP MCLFALEYRQ PLFVRGIGQD ITQLKEACSL 

       190        200        210        220        230        240 
AMVLVNHGQQ IATKAVFKAL EKRDHPPLKI DLESLKTVDS LVEALQETRN DLFIPALKIA 

       250        260        270        280        290        300 
PQLSEVLYAL DESGALFSRM SGTGATCFGI FKDKEAAQQA ALFIKLMHPD WFVKPIITLG 


ML 

« Hide

References

[1]"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae."
Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E.
Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Toulouse.

Cross-references

Sequence databases

BX897700 Genomic DNA. Translation: CAF25823.1.
RefSeqYP_032011.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2866968.
GenomeReviewsGene locus BQ03230 in contig BX897700_GR.
KEGGbqu:BQ03230.
NMPDRfig|283165.1.peg.281.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ6G0G3.
OMAQETRNDL.

Enzyme and pathway databases

BioCycBQUI283165:BQ03230-MON.
BRENDA2.7.1.148. 292235.

Family and domain databases

HAMAPMF_00061.
[Tree]
InterProIPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR004424. IspE.
[Graphical view]
PANTHERPTHR20861:SF2. IspE. 1 hit.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF010376. IspE. 1 hit.
TIGRFAMsTIGR00154. ispE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameISPE_BARQU
AccessionPrimary (citable) accession number: Q6G0G3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 19, 2004
Last modified: November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents