Q6G0G3 (ISPE_BARQU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 48.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase Short name=CMK EC=2.7.1.148 Alternative name(s): 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase | ||||
| Gene names |
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| Organism | Bartonella quintana (strain Toulouse) (Rochalimaea quintana) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 283165 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella |
Protein attributes
| Sequence length | 302 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP MF_00061 |
| Catalytic activity | ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00061 |
| Pathway | Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP MF_00061 |
| Sequence similarities | Belongs to the GHMP kinase family. IspE subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Isoprene biosynthesis |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Inferred from electronic annotation. Source: EC ATP bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 302 | 302 | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP MF_00061 | PRO_0000235069 | |||||
Regions | |||||||||
| Nucleotide binding | 106 – 116 | 11 | ATP Potential | ||||||
Sites | |||||||||
| Active site | 20 | 1 | By similarity | ||||||
| Active site | 148 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Toulouse. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX897700 Genomic DNA. Translation: CAF25823.1. |
| RefSeq | YP_032011.1. NC_005955.1. |
3D structure databases | |
| ProteinModelPortal | Q6G0G3. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 2866968. |
| GenomeReviews | Gene locus BQ03230 in contig BX897700_GR. |
| KEGG | bqu:BQ03230. |
| NMPDR | fig|283165.1.peg.281. |
| PATRIC | 31951855. VBIBarQui58630_0364. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG734593. |
| OMA | VSTAEVY. |
| PhylomeDB | Q6G0G3. |
| ProtClustDB | PRK14608. |
Enzyme and pathway databases | |
| BioCyc | BQUI283165:BQ03230-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00061. IspE. [Tree] |
| InterPro | IPR013750. GHMP_kinase_C. IPR004424. IspE. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view] |
| Gene3D | G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. |
| KO | K00919. |
| PANTHER | PTHR20861:SF2. IspE. 1 hit. |
| Pfam | PF08544. GHMP_kinases_C. 1 hit. [Graphical view] |
| PIRSF | PIRSF010376. IspE. 1 hit. |
| SUPFAM | SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. |
| TIGRFAMs | TIGR00154. IspE. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | ISPE_BARQU | ||||||||
| Accession | Primary (citable) accession number: Q6G0G3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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