Q6G0D4 (DXS_BARQU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	BQ03540

Organism

Bartonella quintana (strain Toulouse) (Rochalimaea quintana) [Complete proteome] [HAMAP]

Taxonomic identifier

283165 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	640 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 640	640	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_0000256381

Sequences

	Sequence		Length	Mass (Da)
	Q6G0D4 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 29BA25ABE15640B4	FASTA	640	69,660
	10 20 30 40 50 60 MSRTLTPLLD RICLPQDLRA LPESDLVRLA DELRTETIDA VSVTGGHLGA GLGVVELTVA 70 80 90 100 110 120 LHYVFNTPED RIIWDVGHQT YPHKILTGRR DRIRTLRQEG GLSGFTKRSE SVYDPFGAGH 130 140 150 160 170 180 SSTSISAGLG MTVASALKAE KRRNIIAVIG DGAMSAGMAY EAMNNAGALD ARLIVILNDN 190 200 210 220 230 240 DMSIAPPTGA MSAHLARLVS RPAYRSLRER IKMFSKKMPK FFLDKARRSE EFARGFLVGG 250 260 270 280 290 300 TLFDELGFYY VGPIDGHNLK HLLPVLKNVR EYPNGPVLVH VVTHKGKGYA PAEASSDKYH 310 320 330 340 350 360 GVNSFDVVTG KQIKTQSNAL AYTKVFSKAL IEEATHDNKI VGITAAMPTG TGLDAFAEKF 370 380 390 400 410 420 PERMFDVGIA EQHAVTFAAG MACEGYKPFV AIYSTFLQRA YDQVIHDVSI QKLPVRFAID 430 440 450 460 470 480 RAGFVGADGA THAGSFDIVF LATLPEFVVM APSDEVELMH MVRTAAAYDQ GPISFRYPRG 490 500 510 520 530 540 EGVGMDLPQR GELLEIGKGR VLREGSRVAL VCFGTRMSEV LVAADALIAE GLSTTVADAR 550 560 570 580 590 600 FAKPLDKDLM RRLACEHEVL VAVEEGAIGG FGAHLLQFLA KEGLLEHGLK VRTLKFPDEY 610 620 630 640 LNHGSPEKVL SRIGLDAVGI VNTVFTALGR EIRTVQKVRV

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Toulouse.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897700 Genomic DNA. Translation: CAF25854.1.
RefSeq	YP_032040.1. NC_005955.1.
3D structure databases
ProteinModelPortal	Q6G0D4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2866512.
GenomeReviews	Gene locus BQ03540 in contig BX897700_GR.
KEGG	bqu:BQ03540.
NMPDR	fig|283165.1.peg.310.
PATRIC	31951931. VBIBarQui58630_0402.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG571647.
OMA	RFANEHD.
PhylomeDB	Q6G0D4.
ProtClustDB	PRK05444.
Enzyme and pathway databases
BioCyc	BQUI283165:BQ03540-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR001017. DH_E1. IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_BARQU

Accession

Primary (citable) accession number: Q6G0D4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program