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Reviewed, UniProtKB/Swiss-Prot Q6G086 (PYRE_BARQU)

Last modified November 3, 2009. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Orotate phosphoribosyltransferase
      Short name=OPRT
      Short name=OPRTase
    EC=2.4.2.10
Gene names
Name: pyrE
Ordered Locus Names: BQ04240
OrganismBartonella quintana (Rochalimaea quintana) [Complete proteome] [HAMAP]
Taxonomic identifier803 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella

Protein attributes

Sequence length192 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity.

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 192192Orotate phosphoribosyltransferase HAMAP MF_01208
PRO_1000066208

Regions

Region116 – 12495-phosphoribose 1-diphosphate binding By similarity

Sites

Binding site1201Orotate By similarity
Binding site1481Orotate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6G086-1 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 14A0FEB16D1332D1

FASTA19220,825
        10         20         30         40         50         60 
MNTQDVIDIF KQADAILEGH FILTSGRHSA IYMQKAQVFM HADLTEKLCR GLAEKIKRSI 

        70         80         90        100        110        120 
KEKIDYVVGP AIGGLIPSYE TSRHLGIPSL WVERVNGIFE LRRFKIKNGA RVVIVEDIVT 

       130        140        150        160        170        180 
TGLSIRETVE ALVAAGADVV ASACILDRSG GKVDVGVPLI ALAEYEIVSY ASDALPTELA 

       190 
LLPAVKPGSR NI 

« Hide

References

[1]"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae."
Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E.
Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Toulouse.

Cross-references

Sequence databases

BX897700 Genomic DNA. Translation: CAF25923.1.
RefSeqYP_032104.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2866815.
GenomeReviewsGene locus BQ04240 in contig BX897700_GR.
KEGGbqu:BQ04240.
NMPDRfig|283165.1.peg.374.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ6G086.
OMAYLQSAKV.

Enzyme and pathway databases

BioCycBQUI283165:BQ04240-MON.
BRENDA2.4.2.10. 292235.

Family and domain databases

HAMAPMF_01208.
[Tree]
InterProIPR006273. Orotate_PRibTrfase_thermus-typ.
IPR002375. Pr/py_Pribosyl_transf_CS.
IPR000836. PRibTrfase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01367. pyrE_Therm. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRE_BARQU
AccessionPrimary (citable) accession number: Q6G086
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 19, 2004
Last modified: November 3, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents