Q6G053 (KGUA_BARQU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	BQ04570

Organism

Bartonella quintana (Rochalimaea quintana) [Complete proteome] [HAMAP]

Taxonomic identifier

803 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity HAMAP MF_00328.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Guanylate kinase HAMAP MF_00328		PRO_0000170501
Regions
	Domain	18 – 196	179	Guanylate kinase-like
	Nucleotide binding	25 – 32	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6G053-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 46FD123BAF2CA463	FASTA	221	25,694
	10 20 30 40 50 60 MTFFESELSA KKRDQRRGFL FILSSPSGAG KSTLSRLLLK DAQLERSVSV TTRQRRPSEV 70 80 90 100 110 120 DGFHYHFVSK QEFECKRDGD EFIEWAEVHG NYYGTLRKSV ENALSAGRDI LFDIDYQGTE 130 140 150 160 170 180 QLQKKMPGDT VSIFILPPSM KELILRLHRR AEDSQDIINL RLKNAQTEMQ HWRFYDYVVI 190 200 210 220 NKDLNQSASL IKSIYLAETA RRKRCSFLES FVDGLIDEKI N

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Toulouse.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897700 Genomic DNA. Translation: CAF25956.1.
RefSeq	YP_032137.1.
3D structure databases
ProteinModelPortal	Q6G053.
SMR	Q6G053. Positions 20-195.
ModBase	Search...
Genome annotation databases
GeneID	2866824.
GenomeReviews	Gene locus BQ04570 in contig BX897700_GR.
KEGG	bqu:BQ04570.
NMPDR	fig|283165.1.peg.407.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG671982.
OMA	PPTWEEL.
PhylomeDB	Q6G053.
ProtClustDB	PRK00300.
Enzyme and pathway databases
BioCyc	BQUI283165:BQ04570-MONOMER.
BRENDA	2.7.4.8. 292235.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_BARQU

Accession

Primary (citable) accession number: Q6G053

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	July 19, 2004
Last modified:	August 10, 2010
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)