Reviewed, UniProtKB/Swiss-Prot Q6FZZ4 (GCH1_BARQU)

Names and origin

Protein names

Recommended name:
    GTP cyclohydrolase 1
    EC=3.5.4.16
Alternative name(s):
    GTP cyclohydrolase I
      Short name=GTP-CH-I

Gene names

Name:	folE
Ordered Locus Names:	BQ05540

Organism

Bartonella quintana (Rochalimaea quintana) [Complete proteome] [HAMAP]

Taxonomic identifier

803 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223
Subunit structure	Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity. HAMAP MF_00223
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	GTP cyclohydrolase 1 HAMAP MF_00223		PRO_1000043666
Sites
	Metal binding	95	1	Zinc By similarity
	Metal binding	98	1	Zinc By similarity
	Metal binding	166	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6FZZ4-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 3152150F29C1C991	FASTA	206	23,255
	10 20 30 40 50 60 MHNIKGGTKN PFLSGRKRPH FEEVEAAIRT LLLWIGENPN REGLLDTPRR VAKAYRDLFI 70 80 90 100 110 120 GYGESVEEIL GTVFEEVSGY NEPVIVKDIS FYSHCEHHMI PIVGKAHIAY LPDEKVVGLS 130 140 150 160 170 180 KIARIVDVFS RRLQTQETMT AQIADALEEY LKPCGIAVLI EAEHMCMTMR GVQKQGATTI 190 200 TTSFHGSYEK DQVAQTNFMM IVRRSS

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Toulouse.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897700 Genomic DNA. Translation: CAF26049.1.
RefSeq	YP_032216.1.
3D structure databases
HSSP	HSSP built from PDB template 1IS8 based on UniProtKB P22288.
SMR	Q6FZZ4. Positions 21-203.
ModBase	Search...
Genome annotation databases
GeneID	2867402.
GenomeReviews	Gene locus BQ05540 in contig BX897700_GR.
KEGG	bqu:BQ05540.
NMPDR	fig|283165.1.peg.486.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG370191.
OMA	HMVPFIG.
PhylomeDB	Q6FZZ4.
Enzyme and pathway databases
BioCyc	BQUI283165:BQ05540-MONOMER.
BRENDA	3.5.4.16. 292235.
Family and domain databases
HAMAP	MF_00223. FolE. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. folE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH1_BARQU

Accession

Primary (citable) accession number: Q6FZZ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)