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Q6FZP6

- SYE1_BARQU

UniProt

Q6FZP6 - SYE1_BARQU

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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Bartonella quintana (strain Toulouse) (Rochalimaea quintana)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei252 – 2521ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBQUI283165:GHZA-676-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:BQ06770
OrganismiBartonella quintana (strain Toulouse) (Rochalimaea quintana)
Taxonomic identifieri283165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000597: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459Glutamate--tRNA ligase 1PRO_0000119512Add
BLAST

Proteomic databases

PRIDEiQ6FZP6.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi283165.BQ06770.

Structurei

3D structure databases

ProteinModelPortaliQ6FZP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi8 – 1811"HIGH" regionAdd
BLAST
Motifi249 – 2535"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000252721.
KOiK01885.
OMAiRIALFNW.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FZP6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKVRFAPSP TGYIHIGNIR IALFNWLYAQ AHNGAFILRY DDTDVERSKQ
60 70 80 90 100
EYIDAIAADL EWLDIQPDEI YYQSKRFNRY DEVAEMLKQR GLLYPCYETA
110 120 130 140 150
EELDRRRKIQ LSRKLPPVYD RAALKLTPEE KEEFESQGRK PHWRFLLPNF
160 170 180 190 200
ENNPLQTKRT EVCWNDVVKG KQTIDLASLS DPVLIREGGS YLYTLPSVVD
210 220 230 240 250
DIDMAITHII RGDDHITNTG VQIALFEALN AQLPIFGHIN LLTTVLGKGL
260 270 280 290 300
SKRDNDLSIH SLRAEGFESI AIQCFAVLIG TSQNVHPYPH QAALLKHFNL
310 320 330 340 350
QDTSRSVTKF DIADLFALNS HLVHDLTYEE VKTRLKNLSI DGEKAECFWN
360 370 380 390 400
AIRSNIDKVN DAVLWWKMIH DEQSFDPVAL EDRSFVRQSL NFLPEGPLND
410 420 430 440 450
ESWKVWTTTL KEKTGRRGKA LFMPLRQALT GMDHGPEMGK LLQLLGREKV

IDRLTIQGE
Length:459
Mass (Da):52,789
Last modified:July 19, 2004 - v1
Checksum:iB2E0734CD0F05C2E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897700 Genomic DNA. Translation: CAF26166.1.
RefSeqiWP_011179421.1. NC_005955.1.
YP_032314.1. NC_005955.1.

Genome annotation databases

EnsemblBacteriaiCAF26166; CAF26166; BQ06770.
GeneIDi2867044.
KEGGibqu:BQ06770.
PATRICi31952651. VBIBarQui58630_0751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897700 Genomic DNA. Translation: CAF26166.1 .
RefSeqi WP_011179421.1. NC_005955.1.
YP_032314.1. NC_005955.1.

3D structure databases

ProteinModelPortali Q6FZP6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 283165.BQ06770.

Proteomic databases

PRIDEi Q6FZP6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF26166 ; CAF26166 ; BQ06770 .
GeneIDi 2867044.
KEGGi bqu:BQ06770.
PATRICi 31952651. VBIBarQui58630_0751.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000252721.
KOi K01885.
OMAi RIALFNW.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci BQUI283165:GHZA-676-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Toulouse.

Entry informationi

Entry nameiSYE1_BARQU
AccessioniPrimary (citable) accession number: Q6FZP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3