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Q6FZN9

- SYE2_BARQU

UniProt

Q6FZN9 - SYE2_BARQU

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Protein
Glutamate--tRNA ligase 2
Gene
gltX2, BQ06840
Organism
Bartonella quintana (strain Toulouse) (Rochalimaea quintana)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei241 – 2411ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBQUI283165:GHZA-683-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 2 (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase 2
Short name:
GluRS 2
Gene namesi
Name:gltX2
Ordered Locus Names:BQ06840
OrganismiBartonella quintana (strain Toulouse) (Rochalimaea quintana)
Taxonomic identifieri283165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000597: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Glutamate--tRNA ligase 2UniRule annotation
PRO_0000119513Add
BLAST

Proteomic databases

PRIDEiQ6FZN9.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi283165.BQ06840.

Structurei

3D structure databases

ProteinModelPortaliQ6FZN9.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi9 – 1911"HIGH" regionUniRule annotation
Add
BLAST
Motifi238 – 2425"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000252722.
KOiK01885.
OMAiVTGQTHG.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FZN9-1 [UniParc]FASTAAdd to Basket

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MSVITRFAPS PTGFLHIGSA RTALFNWLYA KHTGGKMLLR IEDTDRERST    50
ETALKAIIDG LHWMGLSYDG DPISQFERAE RHRQVAKQLV KDGKAYYCYA 100
SPEELAEMRE NARAEGRPPR YDGRWRDRDI SEAPKGVKPV IRIKAPQDGE 150
TVLHDRVQGD VRFPNKDLDD FIILRSDGSP TYMHAVVVDD HDMGVTHIIR 200
GDDHLTNAAR QTIIFNALGW DIPVMAHIPL IHGENGAKLS KRHGALGVDA 250
YRIMGYLPAA LRNYLVRLGW SHGDDELMSI ESMIFWFDID DINKSAARFD 300
LKKLDAINGH YIRMNNDQDL FDAVLNILPE IEGGLEIIER LDEQRRAQFL 350
AAIPNLKERS KTLRELIDNA SFIFTKRPLL LDEKAQILLD KNGQAILNGL 400
YLALKACLSW DAKTLDETLR VYAQKQDLKF GDVAQPLRAA LTGRVTSPGV 450
FDVLVLLGRD EALNRITDQL VTTAC 475
Length:475
Mass (Da):53,619
Last modified:July 19, 2004 - v1
Checksum:iCA1C2409B8D94563
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897700 Genomic DNA. Translation: CAF26173.1.
RefSeqiWP_011179428.1. NC_005955.1.
YP_032321.1. NC_005955.1.

Genome annotation databases

EnsemblBacteriaiCAF26173; CAF26173; BQ06840.
GeneIDi2866836.
KEGGibqu:BQ06840.
PATRICi31952665. VBIBarQui58630_0758.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897700 Genomic DNA. Translation: CAF26173.1 .
RefSeqi WP_011179428.1. NC_005955.1.
YP_032321.1. NC_005955.1.

3D structure databases

ProteinModelPortali Q6FZN9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 283165.BQ06840.

Proteomic databases

PRIDEi Q6FZN9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF26173 ; CAF26173 ; BQ06840 .
GeneIDi 2866836.
KEGGi bqu:BQ06840.
PATRICi 31952665. VBIBarQui58630_0758.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000252722.
KOi K01885.
OMAi VTGQTHG.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci BQUI283165:GHZA-683-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Toulouse.

Entry informationi

Entry nameiSYE2_BARQU
AccessioniPrimary (citable) accession number: Q6FZN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 19, 2004
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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