Reviewed, UniProtKB/Swiss-Prot Q6FZI4 (SYD_BARQU)

Names and origin

Protein names

Recommended name:
    Aspartyl-tRNA synthetase
    EC=6.1.1.12
Alternative name(s):
    Aspartate--tRNA ligase
      Short name=AspRS

Gene names

Name:	aspS
Ordered Locus Names:	BQ07550

Organism

Bartonella quintana (Rochalimaea quintana) [Complete proteome] [HAMAP]

Taxonomic identifier

803 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	597 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). HAMAP MF_00044
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm. HAMAP MF_00044
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aspartyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP aspartate-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 597	597	Aspartyl-tRNA synthetase HAMAP MF_00044		PRO_0000110832

Sequences

	Sequence		Length	Mass (Da)
	Q6FZI4-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 1EC39A18BF353CA1	FASTA	597	67,815
	10 20 30 40 50 60 MHRYRSHNCA ALRKHDVGKH VRLSGWVHRV RDHGGILFVD LRDHFGITQI VANPASPAFE 70 80 90 100 110 120 IIEKVRSEWV IRVDGEVCAR SDEVINTVLP TGEIEIFVKE VEILSKSDEL PLPVFGEPDY 130 140 150 160 170 180 PEDIRLKYRF LDLRRETMHK NIMRRTEIIT AIRRSMQNNG FTEFTTPLLT ASSPEGARDF 190 200 210 220 230 240 LVPSRIHQGK FYALPQAPQQ YKQLLMMSGF DRYFQIAPCF RDEDPRADRL PGEFYQLDVE 250 260 270 280 290 300 MSFVEQEDVF VTMEPIMRSI FEEFANGKPV TQNFPRISYD EAIKKYGSDK PDLRNPIIMQ 310 320 330 340 350 360 DVSQHFYDSC FKIFAQILTN DENAQVWAIP AKTGGSRAFC DRMNLWAQSE GQPGLGYIFW 370 380 390 400 410 420 REEEGKFEGA GPIAKNIGEQ RTEALRIQLG LESGDACFFI AGNPKKFSTF AGAVRTRIGE 430 440 450 460 470 480 ELDLIDRECF SLAWIVDFPF FEWNEDEKKL DFAHNPFSMP QGGKNALECQ DPLTLKAFQY 490 500 510 520 530 540 DLVCNGYEIA SGGIRNHSPE MMLKVFNLAG LSREVVEDRF GALYRAFHYG APPHGGMAAG 550 560 570 580 590 VDRIIMLLQG VKNLREIALF PMNQQALDLL MSAPSDVSSA QLRDLGIRVA PAAKNGS

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Toulouse.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX897700 Genomic DNA. Translation: CAF26239.1.
RefSeq	YP_032384.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2866839.
GenomeReviews	Gene locus BQ07550 in contig BX897700_GR.
KEGG	bqu:BQ07550.
NMPDR	fig|283165.1.peg.654.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6FZI4.
OMA	Q6FZI4. YQLDVEM.
Enzyme and pathway databases
BioCyc	BQUI283165:BQ07550-MON.
BRENDA	6.1.1.12. 292235.
Family and domain databases
HAMAP	MF_00044. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II_cons-reg. IPR002312. Asp-tRNA-synth_IIb. IPR004524. Asp-tRNA-synth_IIb_bac/mt. IPR018153. Asp-tRNA-synth_IIb_C_bac/mt. IPR004115. GAD. IPR012340. NA-bd_OB-fold. IPR004365. NA_bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF5. AspS_bac. 1 hit.
Pfam	PF02938. GAD. 1 hit. PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
TIGRFAMs	TIGR00459. aspS_bact. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYD_BARQU

Accession

Primary (citable) accession number: Q6FZI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	July 19, 2004
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)