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Q6FZH6

- GLMS_BARQU

UniProt

Q6FZH6 - GLMS_BARQU

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Bartonella quintana (strain Toulouse) (Rochalimaea quintana)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei602 – 6021For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciBQUI283165:GHZA-763-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:BQ07640
OrganismiBartonella quintana (strain Toulouse) (Rochalimaea quintana)
Taxonomic identifieri283165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000597: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 607606Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135303Add
BLAST

Proteomic databases

PRIDEiQ6FZH6.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi283165.BQ07640.

Structurei

3D structure databases

ProteinModelPortaliQ6FZH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini277 – 422146SIS 1UniRule annotationAdd
BLAST
Domaini455 – 597143SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6FZH6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIIGILGK KCVASSLIAG LKRLEYRGYD SSGIATVHNG RLYRVRAEGK
60 70 80 90 100
LVHLEEKLKK TPLKGSLGIG HTRWATHGVA VERNAHPHVT ERLAIVHNGI
110 120 130 140 150
IENFVELQKE LIEEGYTFET ETDTEVIAHL ITRALKSGLS QQEAIRTSWK
160 170 180 190 200
RLQGAFAIVV IFEGQDNLMI AARSGPPLAI GYGQDEFFVG SDAVALASFV
210 220 230 240 250
DRISYMEDGD WAVLTREGVT IYGADNQPVK RPITTLFEGT LLVSKGNHRH
260 270 280 290 300
FMHKEMFEQP EVISHNLAHY LDLGNYTVRS LKNLIDWKKI NRILFASCGT
310 320 330 340 350
AYYSTLVARY WFENFAALSV DNDIASEFRY REPPITSDVL SVFVSQSGET
360 370 380 390 400
ADTLACLRYC REHGVKTATI VNVEQSTMAR EADFILPTRA GPEIGVASTK
410 420 430 440 450
AFTCQLATLA AMALDAAKQR GSLSEKAEHQ FVQQLAEVPR ILNEVLKLDD
460 470 480 490 500
KIEQICRDLV NVRGVLYLGR GTSYPIALEG ALKLKELSYI HAEGYAAGEL
510 520 530 540 550
KHGPIALVDE AIPVIVVAPY DRWFEKTFSN MQEVAARNGR IILITDKRGA
560 570 580 590 600
EVAGLDTLST IVLPNIPEFI APIIYALPIQ LIAYHTAVLL GTDVDQPRNL

AKSVTVE
Length:607
Mass (Da):67,131
Last modified:January 23, 2007 - v3
Checksum:i040A4F77DA931916
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897700 Genomic DNA. Translation: CAF26248.1.
RefSeqiYP_032392.1. NC_005955.1.

Genome annotation databases

EnsemblBacteriaiCAF26248; CAF26248; BQ07640.
GeneIDi2867120.
KEGGibqu:BQ07640.
PATRICi31952829. VBIBarQui58630_0835.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897700 Genomic DNA. Translation: CAF26248.1 .
RefSeqi YP_032392.1. NC_005955.1.

3D structure databases

ProteinModelPortali Q6FZH6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 283165.BQ07640.

Protein family/group databases

MEROPSi C44.971.

Proteomic databases

PRIDEi Q6FZH6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF26248 ; CAF26248 ; BQ07640 .
GeneIDi 2867120.
KEGGi bqu:BQ07640.
PATRICi 31952829. VBIBarQui58630_0835.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci BQUI283165:GHZA-763-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Toulouse.

Entry informationi

Entry nameiGLMS_BARQU
AccessioniPrimary (citable) accession number: Q6FZH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3