Reviewed, UniProtKB/Swiss-Prot Q6FZ13 (DAPB_BARQU)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	BQ09810

Organism

Bartonella quintana (Rochalimaea quintana) [Complete proteome] [HAMAP]

Taxonomic identifier

803 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 4/4.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Dihydrodipicolinate reductase		PRO_0000228327

Sequences

	Sequence		Length	Mass (Da)
	Q6FZ13-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: B8349B503267BFD9	FASTA	270	29,020
	10 20 30 40 50 60 MRLTVVGANG KMGRELITAI QRREDVELCA VLVRKGSPFV DKDASILTGS DFLNIRITDD 70 80 90 100 110 120 PENAFSNTEG ILDFSQPQAS ILYANYAAQK SLVHIIGTTG FSKTEEEKIA DFAKDTTIVK 130 140 150 160 170 180 SGNMSLGVNL LASLVKKAAK ALEVDDFDIE IYEMHHSGKV DAPSGTALLL GQAAAEGRNV 190 200 210 220 230 240 MLKNVSVNAR NGYTGEREKG TIGFACSRGG TVVGDHSITF AGPNERIVLS HVAQDRSIFA 250 260 270 NGALKAALWA KNHENGLYSM LDVLGLKDEF

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Toulouse.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX897700 Genomic DNA. Translation: CAF26457.1.
RefSeq	YP_032576.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2867460.
GenomeReviews	Gene locus BQ09810 in contig BX897700_GR.
KEGG	bqu:BQ09810.
NMPDR	fig|283165.1.peg.846.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6FZ13.
Enzyme and pathway databases
BioCyc	BQUI283165:BQ09810-MON.
Family and domain databases
HAMAP	MF_00102. [Tree]
InterPro	IPR000846. DapB. IPR011770. DapB_bac/pln. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
ProDom	PD004105. DapB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_BARQU

Accession

Primary (citable) accession number: Q6FZ13

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	July 19, 2004
Last modified:	November 25, 2008
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)