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Q6FYZ7

- GCSP_BARQU

UniProt

Q6FYZ7 - GCSP_BARQU

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Bartonella quintana (strain Toulouse) (Rochalimaea quintana)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBQUI283165:GHZA-1009-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:BQ10110
    OrganismiBartonella quintana (strain Toulouse) (Rochalimaea quintana)
    Taxonomic identifieri283165 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
    ProteomesiUP000000597: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 931931Glycine dehydrogenase (decarboxylating)PRO_0000227094Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei684 – 6841N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiQ6FYZ7.

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi283165.BQ10110.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6FYZ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiAELMPVS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6FYZ7-1 [UniParc]FASTAAdd to Basket

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    MQERSFFSRH IGLRSDETQK MLDVLGLDCI DTLVSQAIPH SIHLGRVLNL    50
    PKAVSEGQAL EELSKIMGRN HVHKSFIGQG YHGTCVPPVI LRNLFENPAW 100
    YTAYTPYQAE ISQGRLELLF YFQTLISELT GLPVAAASLL DEATALAEAN 150
    AVAVRFAREK KTKISLQSLL HPQILSVVQT RAETQGISIS ENSEICSNTA 200
    AIVLSWPDTK GFFNDYSEVI KEAKAKGALV IVVADPLALT LMEPPAQWGA 250
    DIVVGSMQRY GVPMGFGGPH AGYLAVSDAL IRLIPGRIVG QSVDTKGRVG 300
    FRLALQTREQ HIRRDKATSN ICTAQALLAN MATAYAVWHG PQGLQEIAQR 350
    IHSLTCRFMG GLEAAGIPCE GESFFDCVSV VVKGKAQEIA RQAKAGGRLV 400
    RILDDDRVAV NFDELSTEED ACTLAQLFGA QLVDQVSPRL WGKGRDAAFL 450
    SQPFFHVVHS ETDMMRFLRR LSDKDLALDR AMIPLGSCTM KLNAAAELMP 500
    VSWPTVANIH PFVPKEDAAG YQEMINQLNA WLCEITGFAQ VSFQPNSGAQ 550
    GEYAGLLAIR RYYQSRGENQ RTLCLVPASA HGTNPASAHM AGMEVVVVKC 600
    LSDGDVDIDD LKMKAQLHKD RLAALMITYP STHGVYEENI KDICSLIHEN 650
    GGQVYFDGAN LNALVGLTRP ADIGADVCHM NLHKTFAIPH GGGGPGVGPI 700
    GVAEHLKPFL PGHAQNGTTH AVSAAPYGSA SILVITWMYI RMMGAKGLKY 750
    ATQTAILNAN YIAERLSQAY SILYRGKHGR VAHECIVDTR VLKEQYGVSV 800
    DDIAKRLIDY GFHAPTMSFP VPGTLMIEPT ESEPKAEIDR FCDALLSIAE 850
    EAKKVGAGVW PKDDNPLVNA PHTLVDTLDD AWVHPYSRQE AAFPNHHLDP 900
    TNKYWPPVSR IDNVAGDRVL ICSCPPLGNT S 931
    Length:931
    Mass (Da):101,490
    Last modified:July 19, 2004 - v1
    Checksum:i2A3F818FF424589E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX897700 Genomic DNA. Translation: CAF26479.1.
    RefSeqiWP_011179696.1. NC_005955.1.
    YP_032592.1. NC_005955.1.

    Genome annotation databases

    EnsemblBacteriaiCAF26479; CAF26479; BQ10110.
    GeneIDi2867118.
    KEGGibqu:BQ10110.
    PATRICi31953371. VBIBarQui58630_1092.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX897700 Genomic DNA. Translation: CAF26479.1 .
    RefSeqi WP_011179696.1. NC_005955.1.
    YP_032592.1. NC_005955.1.

    3D structure databases

    ProteinModelPortali Q6FYZ7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 283165.BQ10110.

    Proteomic databases

    PRIDEi Q6FYZ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF26479 ; CAF26479 ; BQ10110 .
    GeneIDi 2867118.
    KEGGi bqu:BQ10110.
    PATRICi 31953371. VBIBarQui58630_1092.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi AELMPVS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci BQUI283165:GHZA-1009-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Toulouse.

    Entry informationi

    Entry nameiGCSP_BARQU
    AccessioniPrimary (citable) accession number: Q6FYZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3