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Q6FYZ7

- GCSP_BARQU

UniProt

Q6FYZ7 - GCSP_BARQU

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, BQ10110
Organism
Bartonella quintana (strain Toulouse) (Rochalimaea quintana)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBQUI283165:GHZA-1009-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:BQ10110
OrganismiBartonella quintana (strain Toulouse) (Rochalimaea quintana)
Taxonomic identifieri283165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000597: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 931931Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000227094Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei684 – 6841N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ6FYZ7.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi283165.BQ10110.

Structurei

3D structure databases

ProteinModelPortaliQ6FYZ7.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiAELMPVS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FYZ7-1 [UniParc]FASTAAdd to Basket

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MQERSFFSRH IGLRSDETQK MLDVLGLDCI DTLVSQAIPH SIHLGRVLNL    50
PKAVSEGQAL EELSKIMGRN HVHKSFIGQG YHGTCVPPVI LRNLFENPAW 100
YTAYTPYQAE ISQGRLELLF YFQTLISELT GLPVAAASLL DEATALAEAN 150
AVAVRFAREK KTKISLQSLL HPQILSVVQT RAETQGISIS ENSEICSNTA 200
AIVLSWPDTK GFFNDYSEVI KEAKAKGALV IVVADPLALT LMEPPAQWGA 250
DIVVGSMQRY GVPMGFGGPH AGYLAVSDAL IRLIPGRIVG QSVDTKGRVG 300
FRLALQTREQ HIRRDKATSN ICTAQALLAN MATAYAVWHG PQGLQEIAQR 350
IHSLTCRFMG GLEAAGIPCE GESFFDCVSV VVKGKAQEIA RQAKAGGRLV 400
RILDDDRVAV NFDELSTEED ACTLAQLFGA QLVDQVSPRL WGKGRDAAFL 450
SQPFFHVVHS ETDMMRFLRR LSDKDLALDR AMIPLGSCTM KLNAAAELMP 500
VSWPTVANIH PFVPKEDAAG YQEMINQLNA WLCEITGFAQ VSFQPNSGAQ 550
GEYAGLLAIR RYYQSRGENQ RTLCLVPASA HGTNPASAHM AGMEVVVVKC 600
LSDGDVDIDD LKMKAQLHKD RLAALMITYP STHGVYEENI KDICSLIHEN 650
GGQVYFDGAN LNALVGLTRP ADIGADVCHM NLHKTFAIPH GGGGPGVGPI 700
GVAEHLKPFL PGHAQNGTTH AVSAAPYGSA SILVITWMYI RMMGAKGLKY 750
ATQTAILNAN YIAERLSQAY SILYRGKHGR VAHECIVDTR VLKEQYGVSV 800
DDIAKRLIDY GFHAPTMSFP VPGTLMIEPT ESEPKAEIDR FCDALLSIAE 850
EAKKVGAGVW PKDDNPLVNA PHTLVDTLDD AWVHPYSRQE AAFPNHHLDP 900
TNKYWPPVSR IDNVAGDRVL ICSCPPLGNT S 931
Length:931
Mass (Da):101,490
Last modified:July 19, 2004 - v1
Checksum:i2A3F818FF424589E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897700 Genomic DNA. Translation: CAF26479.1.
RefSeqiWP_011179696.1. NC_005955.1.
YP_032592.1. NC_005955.1.

Genome annotation databases

EnsemblBacteriaiCAF26479; CAF26479; BQ10110.
GeneIDi2867118.
KEGGibqu:BQ10110.
PATRICi31953371. VBIBarQui58630_1092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX897700 Genomic DNA. Translation: CAF26479.1 .
RefSeqi WP_011179696.1. NC_005955.1.
YP_032592.1. NC_005955.1.

3D structure databases

ProteinModelPortali Q6FYZ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 283165.BQ10110.

Proteomic databases

PRIDEi Q6FYZ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF26479 ; CAF26479 ; BQ10110 .
GeneIDi 2867118.
KEGGi bqu:BQ10110.
PATRICi 31953371. VBIBarQui58630_1092.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi AELMPVS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci BQUI283165:GHZA-1009-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Toulouse.

Entry informationi

Entry nameiGCSP_BARQU
AccessioniPrimary (citable) accession number: Q6FYZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 19, 2004
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi