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Q6FYZ7 (GCSP_BARQU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:BQ10110
OrganismBartonella quintana (strain Toulouse) (Rochalimaea quintana) [Complete proteome] [HAMAP]
Taxonomic identifier283165 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella

Protein attributes

Sequence length931 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 931931Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000227094

Amino acid modifications

Modified residue6841N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FYZ7 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 2A3F818FF424589E

FASTA931101,490
        10         20         30         40         50         60 
MQERSFFSRH IGLRSDETQK MLDVLGLDCI DTLVSQAIPH SIHLGRVLNL PKAVSEGQAL 

        70         80         90        100        110        120 
EELSKIMGRN HVHKSFIGQG YHGTCVPPVI LRNLFENPAW YTAYTPYQAE ISQGRLELLF 

       130        140        150        160        170        180 
YFQTLISELT GLPVAAASLL DEATALAEAN AVAVRFAREK KTKISLQSLL HPQILSVVQT 

       190        200        210        220        230        240 
RAETQGISIS ENSEICSNTA AIVLSWPDTK GFFNDYSEVI KEAKAKGALV IVVADPLALT 

       250        260        270        280        290        300 
LMEPPAQWGA DIVVGSMQRY GVPMGFGGPH AGYLAVSDAL IRLIPGRIVG QSVDTKGRVG 

       310        320        330        340        350        360 
FRLALQTREQ HIRRDKATSN ICTAQALLAN MATAYAVWHG PQGLQEIAQR IHSLTCRFMG 

       370        380        390        400        410        420 
GLEAAGIPCE GESFFDCVSV VVKGKAQEIA RQAKAGGRLV RILDDDRVAV NFDELSTEED 

       430        440        450        460        470        480 
ACTLAQLFGA QLVDQVSPRL WGKGRDAAFL SQPFFHVVHS ETDMMRFLRR LSDKDLALDR 

       490        500        510        520        530        540 
AMIPLGSCTM KLNAAAELMP VSWPTVANIH PFVPKEDAAG YQEMINQLNA WLCEITGFAQ 

       550        560        570        580        590        600 
VSFQPNSGAQ GEYAGLLAIR RYYQSRGENQ RTLCLVPASA HGTNPASAHM AGMEVVVVKC 

       610        620        630        640        650        660 
LSDGDVDIDD LKMKAQLHKD RLAALMITYP STHGVYEENI KDICSLIHEN GGQVYFDGAN 

       670        680        690        700        710        720 
LNALVGLTRP ADIGADVCHM NLHKTFAIPH GGGGPGVGPI GVAEHLKPFL PGHAQNGTTH 

       730        740        750        760        770        780 
AVSAAPYGSA SILVITWMYI RMMGAKGLKY ATQTAILNAN YIAERLSQAY SILYRGKHGR 

       790        800        810        820        830        840 
VAHECIVDTR VLKEQYGVSV DDIAKRLIDY GFHAPTMSFP VPGTLMIEPT ESEPKAEIDR 

       850        860        870        880        890        900 
FCDALLSIAE EAKKVGAGVW PKDDNPLVNA PHTLVDTLDD AWVHPYSRQE AAFPNHHLDP 

       910        920        930 
TNKYWPPVSR IDNVAGDRVL ICSCPPLGNT S 

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References

[1]"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae."
Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E.
Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Toulouse.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX897700 Genomic DNA. Translation: CAF26479.1.
RefSeqYP_032592.1. NC_005955.1.

3D structure databases

ProteinModelPortalQ6FYZ7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING283165.BQ10110.

Proteomic databases

PRIDEQ6FYZ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAF26479; CAF26479; BQ10110.
GeneID2867118.
KEGGbqu:BQ10110.
PATRIC31953371. VBIBarQui58630_1092.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAIRVQVII.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycBQUI283165:GHZA-1009-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_BARQU
AccessionPrimary (citable) accession number: Q6FYZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 19, 2004
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families