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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Bartonella quintana (strain Toulouse) (Rochalimaea quintana)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBQUI283165:GHZA-1009-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:BQ10110
OrganismiBartonella quintana (strain Toulouse) (Rochalimaea quintana)
Taxonomic identifieri283165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 931931Glycine dehydrogenase (decarboxylating)PRO_0000227094Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei684 – 6841N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiQ6FYZ7.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi283165.BQ10110.

Structurei

3D structure databases

ProteinModelPortaliQ6FYZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiPHYKTLY.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FYZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQERSFFSRH IGLRSDETQK MLDVLGLDCI DTLVSQAIPH SIHLGRVLNL
60 70 80 90 100
PKAVSEGQAL EELSKIMGRN HVHKSFIGQG YHGTCVPPVI LRNLFENPAW
110 120 130 140 150
YTAYTPYQAE ISQGRLELLF YFQTLISELT GLPVAAASLL DEATALAEAN
160 170 180 190 200
AVAVRFAREK KTKISLQSLL HPQILSVVQT RAETQGISIS ENSEICSNTA
210 220 230 240 250
AIVLSWPDTK GFFNDYSEVI KEAKAKGALV IVVADPLALT LMEPPAQWGA
260 270 280 290 300
DIVVGSMQRY GVPMGFGGPH AGYLAVSDAL IRLIPGRIVG QSVDTKGRVG
310 320 330 340 350
FRLALQTREQ HIRRDKATSN ICTAQALLAN MATAYAVWHG PQGLQEIAQR
360 370 380 390 400
IHSLTCRFMG GLEAAGIPCE GESFFDCVSV VVKGKAQEIA RQAKAGGRLV
410 420 430 440 450
RILDDDRVAV NFDELSTEED ACTLAQLFGA QLVDQVSPRL WGKGRDAAFL
460 470 480 490 500
SQPFFHVVHS ETDMMRFLRR LSDKDLALDR AMIPLGSCTM KLNAAAELMP
510 520 530 540 550
VSWPTVANIH PFVPKEDAAG YQEMINQLNA WLCEITGFAQ VSFQPNSGAQ
560 570 580 590 600
GEYAGLLAIR RYYQSRGENQ RTLCLVPASA HGTNPASAHM AGMEVVVVKC
610 620 630 640 650
LSDGDVDIDD LKMKAQLHKD RLAALMITYP STHGVYEENI KDICSLIHEN
660 670 680 690 700
GGQVYFDGAN LNALVGLTRP ADIGADVCHM NLHKTFAIPH GGGGPGVGPI
710 720 730 740 750
GVAEHLKPFL PGHAQNGTTH AVSAAPYGSA SILVITWMYI RMMGAKGLKY
760 770 780 790 800
ATQTAILNAN YIAERLSQAY SILYRGKHGR VAHECIVDTR VLKEQYGVSV
810 820 830 840 850
DDIAKRLIDY GFHAPTMSFP VPGTLMIEPT ESEPKAEIDR FCDALLSIAE
860 870 880 890 900
EAKKVGAGVW PKDDNPLVNA PHTLVDTLDD AWVHPYSRQE AAFPNHHLDP
910 920 930
TNKYWPPVSR IDNVAGDRVL ICSCPPLGNT S
Length:931
Mass (Da):101,490
Last modified:July 19, 2004 - v1
Checksum:i2A3F818FF424589E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897700 Genomic DNA. Translation: CAF26479.1.
RefSeqiWP_011179696.1. NC_005955.1.
YP_032592.1. NC_005955.1.

Genome annotation databases

EnsemblBacteriaiCAF26479; CAF26479; BQ10110.
KEGGibqu:BQ10110.
PATRICi31953371. VBIBarQui58630_1092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897700 Genomic DNA. Translation: CAF26479.1.
RefSeqiWP_011179696.1. NC_005955.1.
YP_032592.1. NC_005955.1.

3D structure databases

ProteinModelPortaliQ6FYZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283165.BQ10110.

Proteomic databases

PRIDEiQ6FYZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF26479; CAF26479; BQ10110.
KEGGibqu:BQ10110.
PATRICi31953371. VBIBarQui58630_1092.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiPHYKTLY.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciBQUI283165:GHZA-1009-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Toulouse.

Entry informationi

Entry nameiGCSP_BARQU
AccessioniPrimary (citable) accession number: Q6FYZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 19, 2004
Last modified: June 24, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.