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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Bartonella quintana (strain Toulouse) (Rochalimaea quintana)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBQUI283165:GHZA-1081-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligaseUniRule annotation (EC:6.1.1.21UniRule annotation)
Alternative name(s):
Histidyl-tRNA synthetaseUniRule annotation
Short name:
HisRSUniRule annotation
Gene namesi
Name:hisSUniRule annotation
Ordered Locus Names:BQ10830
OrganismiBartonella quintana (strain Toulouse) (Rochalimaea quintana)
Taxonomic identifieri283165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Histidine--tRNA ligasePRO_0000136112Add
BLAST

Proteomic databases

PRIDEiQ6FYU5.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi283165.BQ10830.

Structurei

3D structure databases

ProteinModelPortaliQ6FYU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0124.
HOGENOMiHOG000018071.
KOiK01892.
OMAiRRYQMQR.
OrthoDBiEOG6BPDH4.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FYU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKQEKTKA RLPRGFIDRT SAQLYATETM IAQIREVYEL YGFEALETPI
60 70 80 90 100
FEYTDVLGKF LPDEDRPNAG VFSLQDEDEQ WMSLRYDLTA PLARYFAENF
110 120 130 140 150
EILPKPYRSY RLGFVFRNEK PGPGRFRQFM QFDADIVGTP TVAADAEICM
160 170 180 190 200
MAADSLEKLG FQHHDYVIRL NNRKILEAVL EQIGLVGREK AEKRLTVLRA
210 220 230 240 250
IDKLDKFGLE GVRLLLGKGR LDESGDFTKG AQLKDQEIDS VLALLTGEAE
260 270 280 290 300
TAEETLDALR HVVGHHIQGL EGVRELEEMQ AIFAANGYQN RIKIDPSVVR
310 320 330 340 350
GLEYYTGPVF EATLLFDVLN DDGQKVVFGS IGGGGRYDGL VARFRGENVP
360 370 380 390 400
ATGFSIGISR LITALQNLSK LPVKKTPGPV VVLMMDREPE AVAQYQKMVM
410 420 430 440 450
QLRKAGIRAE LYLGASGIKA QMKYADRRQA PCVVIQGSQE RQDRKIQIKD
460 470 480 490
LIEGTRLSRE IKDNQTWRES RPAQITVDEE RLVQAVQDIL ISQNAQKF
Length:498
Mass (Da):56,174
Last modified:July 19, 2004 - v1
Checksum:i039D63B704C27432
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897700 Genomic DNA. Translation: CAF26550.1.
RefSeqiWP_011179747.1. NC_005955.1.
YP_032644.1. NC_005955.1.

Genome annotation databases

EnsemblBacteriaiCAF26550; CAF26550; BQ10830.
KEGGibqu:BQ10830.
PATRICi31953547. VBIBarQui58630_1178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897700 Genomic DNA. Translation: CAF26550.1.
RefSeqiWP_011179747.1. NC_005955.1.
YP_032644.1. NC_005955.1.

3D structure databases

ProteinModelPortaliQ6FYU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283165.BQ10830.

Proteomic databases

PRIDEiQ6FYU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF26550; CAF26550; BQ10830.
KEGGibqu:BQ10830.
PATRICi31953547. VBIBarQui58630_1178.

Phylogenomic databases

eggNOGiCOG0124.
HOGENOMiHOG000018071.
KOiK01892.
OMAiRRYQMQR.
OrthoDBiEOG6BPDH4.

Enzyme and pathway databases

BioCyciBQUI283165:GHZA-1081-MONOMER.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Toulouse.

Entry informationi

Entry nameiSYH_BARQU
AccessioniPrimary (citable) accession number: Q6FYU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 19, 2004
Last modified: June 24, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.