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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bartonella quintana (strain Toulouse) (Rochalimaea quintana)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBQUI283165:GHZA-1229-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BQ12310
OrganismiBartonella quintana (strain Toulouse) (Rochalimaea quintana)
Taxonomic identifieri283165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000597 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 880880Leucine--tRNA ligasePRO_0000151976Add
BLAST

Proteomic databases

PRIDEiQ6FYL6.

Interactioni

Protein-protein interaction databases

STRINGi283165.BQ12310.

Structurei

3D structure databases

ProteinModelPortaliQ6FYL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi49 – 5911"HIGH" regionAdd
BLAST
Motifi638 – 6425"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FYL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIEHSNVGE RYNPRAREQK WQAIWDEKKI FQITEENCRE KYYVLEMFPY
60 70 80 90 100
PSGRIHMGHV RNYTMGDVVA RYKRAKGFDV LHPMGWDAFG MPAENAALQS
110 120 130 140 150
KVHPKTWTYQ NIAVMRGQLK QLGLSLDWSR EFATCDVAYY HRQQMLFLDL
160 170 180 190 200
YQKGLVARKV AKVNWDPVDQ TVLANEQVVD GCGWRSGALV EQRELAQWFF
210 220 230 240 250
KISDFSEDLL AGLEELEQWP EKVRTMQKNW IGKSQGLLIR WALKSTNGAD
260 270 280 290 300
EVCEAFNEVV CYSTRPDTLF GASFLALSVD HPISQALAQK DKALSAFIEN
310 320 330 340 350
CRCGGMTTAA LETAEKQGFC TSLLAVHPFN PRIHLPVYIA NFVLMDYGTG
360 370 380 390 400
AVFGCPAHDQ RDWDFAHKYD LPVQPVVLPK GSDAEDFVIA ETPYTGDGVM
410 420 430 440 450
INSDFLDGLT PQEAFEAAAE RLEGQMLNGQ PQGKRTVQFR LRDWGISRQR
460 470 480 490 500
YWGCPIPIIH CAACGVVPVP RADLPVELPD DVTFDQPGNP LERHEKWQKV
510 520 530 540 550
ACPVCGQSAK RETDTMDTFV DSSWYYARFT APWAQEPVDK NAIAEWLPVQ
560 570 580 590 600
QYIGGIEHAI LHLLYARFFM RAMKLIGYVT VDEPFKGLFT QGMVVHETYR
610 620 630 640 650
DDQGWVSPAE ISIIEKDGKR QAHKLTDQSE VTIGLIEKMS KSKKNVVDPD
660 670 680 690 700
DIIASYGADT VRWFVLSDSP PERDVIWTES GVEGAYRFVQ RVWRCVVLSA
710 720 730 740 750
PVLKEVIPCT GHQGAALELS KAAHRMLCTV EDDLEKFAFN RAIARLYEFL
760 770 780 790 800
NIMAPLLNKI ASVEDEMKAS LRQAMDFFLA LIAPIMPHLA EECHAALGGK
810 820 830 840 850
TLICELPWPV YDPALIVEDC CTLPVQINGK KRGEVTVAAT ASEAMIEEAV
860 870 880
LALDFVQAHL VEKSIKKMII VPQRIVNVVL
Length:880
Mass (Da):99,339
Last modified:July 19, 2004 - v1
Checksum:i135ECA8B81E0C70E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897700 Genomic DNA. Translation: CAF26690.1.
RefSeqiYP_032759.1. NC_005955.1.

Genome annotation databases

EnsemblBacteriaiCAF26690; CAF26690; BQ12310.
KEGGibqu:BQ12310.
PATRICi31953895. VBIBarQui58630_1345.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897700 Genomic DNA. Translation: CAF26690.1.
RefSeqiYP_032759.1. NC_005955.1.

3D structure databases

ProteinModelPortaliQ6FYL6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283165.BQ12310.

Proteomic databases

PRIDEiQ6FYL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF26690; CAF26690; BQ12310.
KEGGibqu:BQ12310.
PATRICi31953895. VBIBarQui58630_1345.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciBQUI283165:GHZA-1229-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Toulouse.

Entry informationi

Entry nameiSYL_BARQU
AccessioniPrimary (citable) accession number: Q6FYL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 19, 2004
Last modified: April 1, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.