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Q6FYL6

- SYL_BARQU

UniProt

Q6FYL6 - SYL_BARQU

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bartonella quintana (strain Toulouse) (Rochalimaea quintana)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei641 – 6411ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBQUI283165:GHZA-1229-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BQ12310
    OrganismiBartonella quintana (strain Toulouse) (Rochalimaea quintana)
    Taxonomic identifieri283165 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
    ProteomesiUP000000597: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 880880Leucine--tRNA ligasePRO_0000151976Add
    BLAST

    Proteomic databases

    PRIDEiQ6FYL6.

    Interactioni

    Protein-protein interaction databases

    STRINGi283165.BQ12310.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6FYL6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi49 – 5911"HIGH" regionAdd
    BLAST
    Motifi638 – 6425"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6FYL6-1 [UniParc]FASTAAdd to Basket

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    MTIEHSNVGE RYNPRAREQK WQAIWDEKKI FQITEENCRE KYYVLEMFPY    50
    PSGRIHMGHV RNYTMGDVVA RYKRAKGFDV LHPMGWDAFG MPAENAALQS 100
    KVHPKTWTYQ NIAVMRGQLK QLGLSLDWSR EFATCDVAYY HRQQMLFLDL 150
    YQKGLVARKV AKVNWDPVDQ TVLANEQVVD GCGWRSGALV EQRELAQWFF 200
    KISDFSEDLL AGLEELEQWP EKVRTMQKNW IGKSQGLLIR WALKSTNGAD 250
    EVCEAFNEVV CYSTRPDTLF GASFLALSVD HPISQALAQK DKALSAFIEN 300
    CRCGGMTTAA LETAEKQGFC TSLLAVHPFN PRIHLPVYIA NFVLMDYGTG 350
    AVFGCPAHDQ RDWDFAHKYD LPVQPVVLPK GSDAEDFVIA ETPYTGDGVM 400
    INSDFLDGLT PQEAFEAAAE RLEGQMLNGQ PQGKRTVQFR LRDWGISRQR 450
    YWGCPIPIIH CAACGVVPVP RADLPVELPD DVTFDQPGNP LERHEKWQKV 500
    ACPVCGQSAK RETDTMDTFV DSSWYYARFT APWAQEPVDK NAIAEWLPVQ 550
    QYIGGIEHAI LHLLYARFFM RAMKLIGYVT VDEPFKGLFT QGMVVHETYR 600
    DDQGWVSPAE ISIIEKDGKR QAHKLTDQSE VTIGLIEKMS KSKKNVVDPD 650
    DIIASYGADT VRWFVLSDSP PERDVIWTES GVEGAYRFVQ RVWRCVVLSA 700
    PVLKEVIPCT GHQGAALELS KAAHRMLCTV EDDLEKFAFN RAIARLYEFL 750
    NIMAPLLNKI ASVEDEMKAS LRQAMDFFLA LIAPIMPHLA EECHAALGGK 800
    TLICELPWPV YDPALIVEDC CTLPVQINGK KRGEVTVAAT ASEAMIEEAV 850
    LALDFVQAHL VEKSIKKMII VPQRIVNVVL 880
    Length:880
    Mass (Da):99,339
    Last modified:July 19, 2004 - v1
    Checksum:i135ECA8B81E0C70E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX897700 Genomic DNA. Translation: CAF26690.1.
    RefSeqiWP_011179859.1. NC_005955.1.
    YP_032759.1. NC_005955.1.

    Genome annotation databases

    EnsemblBacteriaiCAF26690; CAF26690; BQ12310.
    GeneIDi2867619.
    KEGGibqu:BQ12310.
    PATRICi31953895. VBIBarQui58630_1345.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX897700 Genomic DNA. Translation: CAF26690.1 .
    RefSeqi WP_011179859.1. NC_005955.1.
    YP_032759.1. NC_005955.1.

    3D structure databases

    ProteinModelPortali Q6FYL6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 283165.BQ12310.

    Proteomic databases

    PRIDEi Q6FYL6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF26690 ; CAF26690 ; BQ12310 .
    GeneIDi 2867619.
    KEGGi bqu:BQ12310.
    PATRICi 31953895. VBIBarQui58630_1345.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BQUI283165:GHZA-1229-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Toulouse.

    Entry informationi

    Entry nameiSYL_BARQU
    AccessioniPrimary (citable) accession number: Q6FYL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3