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Q6FYL6 (SYL_BARQU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:BQ12310
OrganismBartonella quintana (strain Toulouse) (Rochalimaea quintana) [Complete proteome] [HAMAP]
Taxonomic identifier283165 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella

Protein attributes

Sequence length880 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 880880Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000151976

Regions

Motif49 – 5911"HIGH" region HAMAP-Rule MF_00049
Motif638 – 6425"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6411ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FYL6 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 135ECA8B81E0C70E

FASTA88099,339
        10         20         30         40         50         60 
MTIEHSNVGE RYNPRAREQK WQAIWDEKKI FQITEENCRE KYYVLEMFPY PSGRIHMGHV 

        70         80         90        100        110        120 
RNYTMGDVVA RYKRAKGFDV LHPMGWDAFG MPAENAALQS KVHPKTWTYQ NIAVMRGQLK 

       130        140        150        160        170        180 
QLGLSLDWSR EFATCDVAYY HRQQMLFLDL YQKGLVARKV AKVNWDPVDQ TVLANEQVVD 

       190        200        210        220        230        240 
GCGWRSGALV EQRELAQWFF KISDFSEDLL AGLEELEQWP EKVRTMQKNW IGKSQGLLIR 

       250        260        270        280        290        300 
WALKSTNGAD EVCEAFNEVV CYSTRPDTLF GASFLALSVD HPISQALAQK DKALSAFIEN 

       310        320        330        340        350        360 
CRCGGMTTAA LETAEKQGFC TSLLAVHPFN PRIHLPVYIA NFVLMDYGTG AVFGCPAHDQ 

       370        380        390        400        410        420 
RDWDFAHKYD LPVQPVVLPK GSDAEDFVIA ETPYTGDGVM INSDFLDGLT PQEAFEAAAE 

       430        440        450        460        470        480 
RLEGQMLNGQ PQGKRTVQFR LRDWGISRQR YWGCPIPIIH CAACGVVPVP RADLPVELPD 

       490        500        510        520        530        540 
DVTFDQPGNP LERHEKWQKV ACPVCGQSAK RETDTMDTFV DSSWYYARFT APWAQEPVDK 

       550        560        570        580        590        600 
NAIAEWLPVQ QYIGGIEHAI LHLLYARFFM RAMKLIGYVT VDEPFKGLFT QGMVVHETYR 

       610        620        630        640        650        660 
DDQGWVSPAE ISIIEKDGKR QAHKLTDQSE VTIGLIEKMS KSKKNVVDPD DIIASYGADT 

       670        680        690        700        710        720 
VRWFVLSDSP PERDVIWTES GVEGAYRFVQ RVWRCVVLSA PVLKEVIPCT GHQGAALELS 

       730        740        750        760        770        780 
KAAHRMLCTV EDDLEKFAFN RAIARLYEFL NIMAPLLNKI ASVEDEMKAS LRQAMDFFLA 

       790        800        810        820        830        840 
LIAPIMPHLA EECHAALGGK TLICELPWPV YDPALIVEDC CTLPVQINGK KRGEVTVAAT 

       850        860        870        880 
ASEAMIEEAV LALDFVQAHL VEKSIKKMII VPQRIVNVVL 

« Hide

References

[1]"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae."
Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E.
Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Toulouse.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX897700 Genomic DNA. Translation: CAF26690.1.
RefSeqYP_032759.1. NC_005955.1.

3D structure databases

ProteinModelPortalQ6FYL6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING283165.BQ12310.

Proteomic databases

PRIDEQ6FYL6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAF26690; CAF26690; BQ12310.
GeneID2867619.
KEGGbqu:BQ12310.
PATRIC31953895. VBIBarQui58630_1345.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycBQUI283165:GHZA-1229-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_BARQU
AccessionPrimary (citable) accession number: Q6FYL6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries