Q6FYL4 (ACSA_BARQU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase
EC=6.2.1.1

Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme

Gene names

Name:	acsA
Ordered Locus Names:	BQ12330

Organism

Bartonella quintana (strain Toulouse) (Rochalimaea quintana) [Complete proteome] [HAMAP]

Taxonomic identifier

283165 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	652 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 652	652	Acetyl-coenzyme A synthetase HAMAP MF_01123		PRO_1000065271
Sites
	Active site	517	1	By similarity
Amino acid modifications
	Modified residue	609	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6FYL4 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: B1D59C8E4037ED67	FASTA	652	73,513
	10 20 30 40 50 60 MSEKIYPVPT DIKKNALINE ETYQKWYRES INDPEAFWAK HGQRIEWFKP YTKVKNTSFN 70 80 90 100 110 120 GDVSIQWYED GITNVAYNCI DRHLKNSGNH IALIWEGNNP YHDKKITYNE LYEHVCRFAN 130 140 150 160 170 180 ILKNHGVKKG DRVTIYLPMI PEAAYAMLAC ARIGAIHSVI FAGFSSEAIA DRIVDCKSTF 190 200 210 220 230 240 IITADQGLRG GKLIKLKNNI DHAIDIAARR GVHVNQVLVI RRTSGTIDWV KGRDFWYHEE 250 260 270 280 290 300 ISHAKTDCPA EMMNAEDPLF ILYTSGSTGK PKGVLHTTAG YLVYVSMTHQ YVFDYHPGEI 310 320 330 340 350 360 YWCTADIGWI SGHSYLIYGP LCNGATTLMF EGIPTFPDQG RFWEIVDKHK VNTLYTAPTA 370 380 390 400 410 420 IRALMGAGNS FVEHSKRTSL RLLGTVGEPI NPEAWKWFYH TVGDNRCPIL DTWWQTETGG 430 440 450 460 470 480 HMITPLPGAT QLKAGSATHP FFGVQLQIID GEGNVLEGEA EGNLCIIDSW PGQMRTLYND 490 500 510 520 530 540 HERFIETYFS TYKGKYFTGD GCKRDNDGYY WITGRIDDIL NVSGHRLGTA EIESALVSHP 550 560 570 580 590 600 AISEAAVVGY PHPIKGQGIY SFVTLMEGIT PSEELYKDLI QHVKKEIGSI ALLDKIQFTP 610 620 630 640 650 QLPKTRSGKI MRRILRKIAE NDFDNLGDIS TLAEPQVVDD LIANRQNTEA TA

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Toulouse.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX897700 Genomic DNA. Translation: CAF26692.1.
RefSeq	YP_032761.1. NC_005955.1.
3D structure databases
HSSP	HSSP built from PDB template 1PG4 based on UniProtKB Q8ZKF6.
ProteinModelPortal	Q6FYL4.
SMR	Q6FYL4. Positions 6-646.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2866783.
GenomeReviews	Gene locus BQ12330 in contig BX897700_GR.
KEGG	bqu:BQ12330.
NMPDR	fig|283165.1.peg.1031.
PATRIC	31953901. VBIBarQui58630_1348.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG547964.
OMA	LIQWAGG.
PhylomeDB	Q6FYL4.
ProtClustDB	PRK00174.
Enzyme and pathway databases
BioCyc	BQUI283165:BQ12330-MONOMER.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACSA_BARQU

Accession

Primary (citable) accession number: Q6FYL4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program