Reviewed, UniProtKB/Swiss-Prot Q6FYF1 (GCP_BARQU)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	BQ13010

Organism

Bartonella quintana (Rochalimaea quintana) [Complete proteome] [HAMAP]

Taxonomic identifier

803 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000303277
Sites
	Metal binding	115	1	Zinc Potential
	Metal binding	119	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6FYF1-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 0A474F5692054300	FASTA	364	38,745
	10 20 30 40 50 60 MRLLGIETSC DETAAAVIEH NIEGNSQILS NIVWSQTDNH APYGGVVPEI AARAHVEILD 70 80 90 100 110 120 DLILKALTDA HTKLKDIDAI AVTSGPGLIG GLLVGVMSAK ALSLATGKPF IAVNHLEGHA 130 140 150 160 170 180 LTAVLTHNVA FPYLLLLVSG GHTQTILVHE VGNYQRLGTT IDDALGEAFD KTAKLLGLPY 190 200 210 220 230 240 PGGPALEKAA LLGDKNRISL PRPLKGEKRL DFSFSGLKTA VRQAATAMSP LTENDVADIA 250 260 270 280 290 300 ASFQAAVTDT VYDRVHLALQ YFTHQYPLSH YKGRRPPALV VAGGVAANQA IRLTLQELAH 310 320 330 340 350 360 QHGFEFIAPP LSLCTDNAAM IAFAGAQKFA RGEKNSFDIA PRSRWPLDEK AAPLIGTGRR GTKA

References

[1]

"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed: 15210978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Toulouse.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX897700 Genomic DNA. Translation: CAF26760.1.
RefSeq	YP_032824.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	2866540.
GenomeReviews	Gene locus BQ13010 in contig BX897700_GR.
KEGG	bqu:BQ13010.
NMPDR	fig|283165.1.peg.1094.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6FYF1.
OMA	CKRALKQ.
Enzyme and pathway databases
BioCyc	BQUI283165:BQ13010-MON.
BRENDA	3.4.24.57. 292235.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_BARQU

Accession

Primary (citable) accession number: Q6FYF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)