Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6FYD0

- MDH_BARQU

UniProt

Q6FYD0 - MDH_BARQU

Protein

Malate dehydrogenase

Gene

mdh

Organism
Bartonella quintana (strain Toulouse) (Rochalimaea quintana)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341NADUniRule annotation
    Binding sitei83 – 831SubstrateUniRule annotation
    Binding sitei89 – 891SubstrateUniRule annotation
    Binding sitei96 – 961NADUniRule annotation
    Binding sitei121 – 1211SubstrateUniRule annotation
    Binding sitei152 – 1521SubstrateUniRule annotation
    Active sitei176 – 1761Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156NADUniRule annotation
    Nucleotide bindingi119 – 1213NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBQUI283165:GHZA-1343-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:BQ13450
    OrganismiBartonella quintana (strain Toulouse) (Rochalimaea quintana)
    Taxonomic identifieri283165 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
    ProteomesiUP000000597: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Malate dehydrogenasePRO_0000113438Add
    BLAST

    Proteomic databases

    PRIDEiQ6FYD0.

    Interactioni

    Protein-protein interaction databases

    STRINGi283165.BQ13450.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6FYD0.
    SMRiQ6FYD0. Positions 3-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiYAPSAFV.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6FYD0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARKKIALIG SGMIGGTLAH MIGLKELGDV VLFDIEEGMP QGKALDIAES    50
    SPVDGFDVSL TGANVYEAIE GADVVIVTAG VARKPGMSRD DLLGINLKVM 100
    EQVGAGIKKY ASSAFVICIT NPLDAMVWAL QKFSGLPKQK VVGMAGVLDS 150
    ARFRYFLSKE FKVSVKDVTA FVLGGHGDSM VPLVRYSTVG GISLPDLVKM 200
    GWTTQEKIDQ IIQRVRNGGA EIVGLLKTGS AFYAPAASAI SMAEAYLKDI 250
    KRVVPVATYL SGEYGVKDTY VGVPVVLGAG GVERVIEIDL DKKERSAFEQ 300
    SVNAVKKLCE ACIAIAPCLK 320
    Length:320
    Mass (Da):33,935
    Last modified:July 19, 2004 - v1
    Checksum:i5A8DB8A64348D544
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX897700 Genomic DNA. Translation: CAF26803.1.
    RefSeqiWP_011179957.1. NC_005955.1.
    YP_032859.1. NC_005955.1.

    Genome annotation databases

    EnsemblBacteriaiCAF26803; CAF26803; BQ13450.
    GeneIDi2866465.
    KEGGibqu:BQ13450.
    PATRICi31954167. VBIBarQui58630_1480.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX897700 Genomic DNA. Translation: CAF26803.1 .
    RefSeqi WP_011179957.1. NC_005955.1.
    YP_032859.1. NC_005955.1.

    3D structure databases

    ProteinModelPortali Q6FYD0.
    SMRi Q6FYD0. Positions 3-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 283165.BQ13450.

    Proteomic databases

    PRIDEi Q6FYD0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF26803 ; CAF26803 ; BQ13450 .
    GeneIDi 2866465.
    KEGGi bqu:BQ13450.
    PATRICi 31954167. VBIBarQui58630_1480.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi YAPSAFV.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci BQUI283165:GHZA-1343-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Toulouse.

    Entry informationi

    Entry nameiMDH_BARQU
    AccessioniPrimary (citable) accession number: Q6FYD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3