Reviewed, UniProtKB/Swiss-Prot Q6FXN7 (ETR1_CANGA)

Names and origin

Protein names

Recommended name:
    Probable trans-2-enoyl-CoA reductase, mitochondrial
    EC=1.3.1.38

Gene names

Name:	ETR1
Ordered Locus Names:	CAGL0B04323g

Organism

Candida glabrata (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

5478 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA. May have a role in the mitochondrial synthesis of fatty acids By similarity.
Catalytic activity	Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.
Subunit structure	Homodimer By similarity.
Subcellular location	MitochondrionBy similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	trans-2-enoyl-CoA reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 385		Probable trans-2-enoyl-CoA reductase, mitochondrial		PRO_0000000897

Sequences

	Sequence		Length	Mass (Da)
	Q6FXN7-1 [UniParc]. Last modified April 26, 2005. Version 2. Checksum: 2B2E90144FA5A88C	FASTA	385	42,620
	10 20 30 40 50 60 MSGLRAASVF SPVFKRMASS IPSQFKSIIY NSHSLEDCTG VLSVHNYKPK QDLNKSVVLR 70 80 90 100 110 120 TLAFPINPSD INQLQGVYPS LPEKTLDYST EKPSAIAGNE GLFEVVSLPE HGDHGELKVG 130 140 150 160 170 180 DWVIPVQANQ GTWSNYRVFD KASDLIKVNG LDLYSAATVS VNGCTAYQLV NNYVDWNADG 190 200 210 220 230 240 NEWLIQNAGT SGVSKFVTQI AKARGVKTLS VIRDRDNFEE VAEVLEQKFG ATKVISESQN 250 260 270 280 290 300 NDKDFGKKEL PKVLGDKARV RLALNSVGGK SSSAIARKLE RDALMLTYGG MSKQPVTIPT 310 320 330 340 350 360 SLHIFKGLTS KGYWVTENNK RDPTDKVNTI KGFIDLYKQG KIISPEEEIE TMEWDANNGD 370 380 DQQLLELVKR GITEKGKKKM VLLKW

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / IFO 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR380948 Genomic DNA. Translation: CAG58058.1. Different initiation.
RefSeq	XP_445158.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2886666.
KEGG	cgr:CAGL0B04323g.
Phylogenomic databases
HOGENOM	Q6FXN7.
Family and domain databases
InterPro	IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

ETR1_CANGA

Accession

Primary (citable) accession number: Q6FXN7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	November 4, 2008
This is version 32 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)