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Q6FXN7

- ETR1_CANGA

UniProt

Q6FXN7 - ETR1_CANGA

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Protein

Probable trans-2-enoyl-CoA reductase, mitochondrial

Gene

ETR1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis (By similarity).By similarity

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei162 – 1621NADPBy similarity
Binding sitei378 – 3781NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi190 – 1934NADPBy similarity
Nucleotide bindingi213 – 2153NADPBy similarity
Nucleotide bindingi288 – 2914NADPBy similarity
Nucleotide bindingi313 – 3153NADPBy similarity

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Probable trans-2-enoyl-CoA reductase, mitochondrial (EC:1.3.1.38)
Gene namesi
Name:ETR1
Ordered Locus Names:CAGL0B04323g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome B

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 385Probable trans-2-enoyl-CoA reductase, mitochondrialPRO_0000000897
Transit peptidei1 – ?MitochondrionSequence Analysis

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6FXN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000294683.
InParanoidiQ6FXN7.
OrthoDBiEOG7PS1RH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR018060. HTH_AraC.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6FXN7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGLRAASVF SPVFKRMASS IPSQFKSIIY NSHSLEDCTG VLSVHNYKPK
60 70 80 90 100
QDLNKSVVLR TLAFPINPSD INQLQGVYPS LPEKTLDYST EKPSAIAGNE
110 120 130 140 150
GLFEVVSLPE HGDHGELKVG DWVIPVQANQ GTWSNYRVFD KASDLIKVNG
160 170 180 190 200
LDLYSAATVS VNGCTAYQLV NNYVDWNADG NEWLIQNAGT SGVSKFVTQI
210 220 230 240 250
AKARGVKTLS VIRDRDNFEE VAEVLEQKFG ATKVISESQN NDKDFGKKEL
260 270 280 290 300
PKVLGDKARV RLALNSVGGK SSSAIARKLE RDALMLTYGG MSKQPVTIPT
310 320 330 340 350
SLHIFKGLTS KGYWVTENNK RDPTDKVNTI KGFIDLYKQG KIISPEEEIE
360 370 380
TMEWDANNGD DQQLLELVKR GITEKGKKKM VLLKW
Length:385
Mass (Da):42,620
Last modified:April 26, 2005 - v2
Checksum:i2B2E90144FA5A88C
GO

Sequence cautioni

The sequence CAG58058.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380948 Genomic DNA. Translation: CAG58058.1. Different initiation.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380948 Genomic DNA. Translation: CAG58058.1 . Different initiation.

3D structure databases

ProteinModelPortali Q6FXN7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000294683.
InParanoidi Q6FXN7.
OrthoDBi EOG7PS1RH.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR018060. HTH_AraC.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiETR1_CANGA
AccessioniPrimary (citable) accession number: Q6FXN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3