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Q6FXN7 (ETR1_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable trans-2-enoyl-CoA reductase, mitochondrial

EC=1.3.1.38
Gene names
Name:ETR1
Ordered Locus Names:CAGL0B04323g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.

Catalytic activity

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Sequence caution

The sequence CAG58058.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 385Probable trans-2-enoyl-CoA reductase, mitochondrialPRO_0000000897

Regions

Nucleotide binding190 – 1934NADP By similarity
Nucleotide binding213 – 2153NADP By similarity
Nucleotide binding288 – 2914NADP By similarity
Nucleotide binding313 – 3153NADP By similarity

Sites

Binding site1621NADP By similarity
Binding site3781NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FXN7 [UniParc].

Last modified April 26, 2005. Version 2.
Checksum: 2B2E90144FA5A88C

FASTA38542,620
        10         20         30         40         50         60 
MSGLRAASVF SPVFKRMASS IPSQFKSIIY NSHSLEDCTG VLSVHNYKPK QDLNKSVVLR 

        70         80         90        100        110        120 
TLAFPINPSD INQLQGVYPS LPEKTLDYST EKPSAIAGNE GLFEVVSLPE HGDHGELKVG 

       130        140        150        160        170        180 
DWVIPVQANQ GTWSNYRVFD KASDLIKVNG LDLYSAATVS VNGCTAYQLV NNYVDWNADG 

       190        200        210        220        230        240 
NEWLIQNAGT SGVSKFVTQI AKARGVKTLS VIRDRDNFEE VAEVLEQKFG ATKVISESQN 

       250        260        270        280        290        300 
NDKDFGKKEL PKVLGDKARV RLALNSVGGK SSSAIARKLE RDALMLTYGG MSKQPVTIPT 

       310        320        330        340        350        360 
SLHIFKGLTS KGYWVTENNK RDPTDKVNTI KGFIDLYKQG KIISPEEEIE TMEWDANNGD 

       370        380 
DQQLLELVKR GITEKGKKKM VLLKW 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR380948 Genomic DNA. Translation: CAG58058.1. Different initiation.

3D structure databases

ProteinModelPortalQ6FXN7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOGENOMHOG000294683.
OrthoDBEOG7PS1RH.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR018060. HTH_AraC.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. SSF50129. 1 hit.
ProtoNetSearch...

Entry information

Entry nameETR1_CANGA
AccessionPrimary (citable) accession number: Q6FXN7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: March 19, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families