SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6FXN7

- ETR1_CANGA

UniProt

Q6FXN7 - ETR1_CANGA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable trans-2-enoyl-CoA reductase, mitochondrial
Gene
ETR1, CAGL0B04323g
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei162 – 1621NADP By similarity
Binding sitei378 – 3781NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi190 – 1934NADP By similarity
Nucleotide bindingi213 – 2153NADP By similarity
Nucleotide bindingi288 – 2914NADP By similarity
Nucleotide bindingi313 – 3153NADP By similarity

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
  4. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Probable trans-2-enoyl-CoA reductase, mitochondrial (EC:1.3.1.38)
Gene namesi
Name:ETR1
Ordered Locus Names:CAGL0B04323g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
ProteomesiUP000002428: Chromosome B

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 385Probable trans-2-enoyl-CoA reductase, mitochondrialPRO_0000000897
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6FXN7.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000294683.
OrthoDBiEOG7PS1RH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR018060. HTH_AraC.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6FXN7-1 [UniParc]FASTAAdd to Basket

« Hide

MSGLRAASVF SPVFKRMASS IPSQFKSIIY NSHSLEDCTG VLSVHNYKPK    50
QDLNKSVVLR TLAFPINPSD INQLQGVYPS LPEKTLDYST EKPSAIAGNE 100
GLFEVVSLPE HGDHGELKVG DWVIPVQANQ GTWSNYRVFD KASDLIKVNG 150
LDLYSAATVS VNGCTAYQLV NNYVDWNADG NEWLIQNAGT SGVSKFVTQI 200
AKARGVKTLS VIRDRDNFEE VAEVLEQKFG ATKVISESQN NDKDFGKKEL 250
PKVLGDKARV RLALNSVGGK SSSAIARKLE RDALMLTYGG MSKQPVTIPT 300
SLHIFKGLTS KGYWVTENNK RDPTDKVNTI KGFIDLYKQG KIISPEEEIE 350
TMEWDANNGD DQQLLELVKR GITEKGKKKM VLLKW 385
Length:385
Mass (Da):42,620
Last modified:April 26, 2005 - v2
Checksum:i2B2E90144FA5A88C
GO

Sequence cautioni

The sequence CAG58058.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380948 Genomic DNA. Translation: CAG58058.1. Different initiation.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380948 Genomic DNA. Translation: CAG58058.1 . Different initiation.

3D structure databases

ProteinModelPortali Q6FXN7.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000294683.
OrthoDBi EOG7PS1RH.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR018060. HTH_AraC.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiETR1_CANGA
AccessioniPrimary (citable) accession number: Q6FXN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: March 19, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi