Q6FXI8 (HAT2_CANGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone acetyltransferase type B subunit 2

Gene names

Name:	HAT2
Ordered Locus Names:	CAGL0B03575g

Organism

Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

284593 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates Lys-12 of histone H4 which is required for telomeric silencing By similarity.
Subunit structure	Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. Contains 6 WD repeats.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm Nucleus
Domain	Repeat WD repeat
Molecular function	Chromatin regulator
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	Histone acetyltransferase type B subunit 2		PRO_0000227736
Regions
	Repeat	131 – 171	41	WD 1
	Repeat	177 – 217	41	WD 2
	Repeat	225 – 265	41	WD 3
	Repeat	267 – 307	41	WD 4
	Repeat	311 – 351	41	WD 5
	Repeat	368 – 408	41	WD 6

Sequences

	Sequence		Length	Mass (Da)
	Q6FXI8 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 370A115B385B0283	FASTA	419	47,022
	10 20 30 40 50 60 MSVQLDPSAL QKMAEVAAAA EQQSNEPMTV DEEYELWKSN VPMLYDFVSE TRLTWPTLTV 70 80 90 100 110 120 EWLPQKNLVA ARTRQQLILG THTSGEEQNY LKIGAVDLPV EVTENSKKDR EIDEEDEDMV 130 140 150 160 170 180 LSNVKIVKKF PHDGEITRAR YMPQDDNIIA TINGEGKIFI YDRSKNGVEA LLSTLEYHTE 190 200 210 220 230 240 NGYGLAFNAN EKYSLLSGSD DSNIALWDIS NFEKNIKPTI TFEDAHTDII NDVKWHSSEA 250 260 270 280 290 300 HIFGSVSEDS TMKLFDKRSS QIIHNINTKK PYNTLAFSPF SSNLFAAAGT DNLVYLYDIR 310 320 330 340 350 360 DVSNPLYAMT GHEDAVTAIE FDPNNDGILY SSGSDRRTIV WDLQEIGAEQ TQDEIEDGPP 370 380 390 400 410 EVLMIHAGHK TSINDIAVNP NINWLVASAE EDNIVQIWKC SSNIPRIGGE PEVDLSILD

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR380948 Genomic DNA. Translation: CAG58027.1.
RefSeq	XP_445127.1. XM_445127.1.
3D structure databases
ProteinModelPortal	Q6FXI8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2886650.
GenomeReviews	Gene locus CAGL0B03575g in contig CR380948_GR.
KEGG	cgr:CAGL0B03575g.
Phylogenomic databases
eggNOG	fuNOG07048.
HOGENOM	HBG435352.
OMA	DLMASIN.
OrthoDB	EOG412QFD.
Family and domain databases
InterPro	IPR022052. Histone-bd_RBBP4. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 2 hits.
KO	K10752.
Pfam	PF12265. CAF1C_H4-bd. 1 hit. PF00400. WD40. 5 hits. [Graphical view]
SMART	SM00320. WD40. 6 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 3 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HAT2_CANGA

Accession

Primary (citable) accession number: Q6FXI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program