Q6FXI2 (ACS2_CANGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase 2
EC=6.2.1.1

Alternative name(s):
Acetate--CoA ligase 2
Acyl-activating enzyme 2

Gene names

Name:	ACS2
Ordered Locus Names:	CAGL0B02717g

Organism

Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

284593 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces

Protein attributes

Sequence length	683 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 683	683	Acetyl-coenzyme A synthetase 2		PRO_0000208408

Sequences

	Sequence		Length	Mass (Da)
	Q6FXI2 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 89C07BF8ECD26766	FASTA	683	75,551
	10 20 30 40 50 60 MTLKEHKTVH EAQNAVARQA PEHFYKSQPS RGGFIKDISE YERLYKQSIE DPETFFSEKA 70 80 90 100 110 120 RELLHWDAPF SKVSYGSLEQ GDVAWFLNGK LNASYNCVDR HAFANPDKPA IIYEADDEKD 130 140 150 160 170 180 NYTITFGELL RRVSKVAGIL KSWGVKKGDT VAIYLPMIPE AIIAMLAVVR LGAIHSVVFA 190 200 210 220 230 240 GFSAGSLKDR VVDAGSKVVI TCDEGRRGGK TVHLKKIVDE GLNGVDQVSR ILVFKRTGTE 250 260 270 280 290 300 GIPMKAGRDF WLHEEADKRR SYLPPVPCDA EDPLFLLYTS GSTGSPKGIV HTTGGYLLGA 310 320 330 340 350 360 AMTTKYVFDV HPEDVFFTAG DVGWITGHTY ALYGPLLLGV PTICFESTPA YPDYGRYWRI 370 380 390 400 410 420 VERHKATHFY VAPTAMRLIK RVGEAEISKY DLSSLRVLGS VGEPISPELW EWYNEKIGNN 430 440 450 460 470 480 NCVVCDTFWQ TESGSHLIAP MAGAIPTKPG STTLPFFGID ACIIDPVSGV EIEGNDVEGV 490 500 510 520 530 540 LAVKSPWPSM ARSVWNDHVR YVDTYMKPYP GYYFTGDGAG RDHDGYYWIR GRVDDVVNVS 550 560 570 580 590 600 GHRLSTAEIE ACLVNHENIS ETAVVGINDE LTGQAVIAFV SLKEGYLQND APEGDAEHIT 610 620 630 640 650 660 PSNLRRELIL QVRGEIGPFA SPKCIILVRD LPKTRSGKIM RRVLRKIASN EADQLGDLST 670 680 LANADVVPAI ISACENQFFA EKK

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR380948 Genomic DNA. Translation: CAG57989.1.
RefSeq	XP_445089.1. XM_445089.1.
3D structure databases
ProteinModelPortal	Q6FXI2.
SMR	Q6FXI2. Positions 40-651.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2886546.
GenomeReviews	Gene locus CAGL0B02717g in contig CR380948_GR.
KEGG	cgr:CAGL0B02717g.
Phylogenomic databases
eggNOG	fuNOG05220.
HOGENOM	HBG547964.
OMA	QCHISDT.
OrthoDB	EOG4M0J8W.
Family and domain databases
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACS2_CANGA

Accession

Primary (citable) accession number: Q6FXI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	July 19, 2004
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program