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Q6FXE3

- HEM1_CANGA

UniProt

Q6FXE3 - HEM1_CANGA

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Protein
5-aminolevulinate synthase, mitochondrial
Gene
HEM1, CAGL0B02607g
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pyridoxal phosphate By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei73 – 731Substrate By similarity
Binding sitei186 – 1861Substrate By similarity
Binding sitei205 – 2051Substrate By similarity
Binding sitei238 – 2381Pyridoxal phosphate By similarity
Binding sitei266 – 2661Pyridoxal phosphate By similarity
Binding sitei316 – 3161Pyridoxal phosphate By similarity
Active sitei319 – 3191 By similarity
Binding sitei348 – 3481Pyridoxal phosphate By similarity
Binding sitei349 – 3491Pyridoxal phosphate By similarity
Binding sitei434 – 4341Substrate By similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase, mitochondrial (EC:2.3.1.37)
Alternative name(s):
5-aminolevulinic acid synthase
Delta-ALA synthase
Delta-aminolevulinate synthase
Gene namesi
Name:HEM1
Ordered Locus Names:CAGL0B02607g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
ProteomesiUP000002428: Chromosome B

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 5305-aminolevulinate synthase, mitochondrialPRO_0000001238
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei319 – 3191N6-(pyridoxal phosphate)lysine By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6FXE3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000221020.
KOiK00643.
OMAiHYLQSIN.
OrthoDBiEOG7HHX1P.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6FXE3-1 [UniParc]FASTAAdd to Basket

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MFRPVLKVRP SFSYPYSIVS SRSVRLASTA TANANTAAAT STVAAHGTQE    50
TPFDFEGHFE SELAKKRLDK SYRYFNNINR LAKEFPLAHR QLEDDKVTVW 100
CSNDYLALSK NPQVLDAMRK TIDKYGAGAG GTRNIAGHNI PTMRLEAELA 150
ALHKKEGALV FSSCYVANDA VISLLGQKVK DLVIFSDELN HASMIVGIKH 200
ANRPKHIFRH NDLAQLEEML QMYPKSTPKL IAFESVYSMA GSVADINKIC 250
DLAEKYGALT FLDEVHAVGL YGPHGAGVAE HCDFEAHRVA GIATPPQGDN 300
GRLRTVMDRV DMITGTLGKS FGTVGGYVAA SSKLIDWVRS YAPGFIFTTT 350
LPPAVMAGAA EAIRFQRSHL NLRQDQQRHT AYVKKGLHDL GIPVIPNPSH 400
IVPVLIGNPD LAKQASDILM EKHRIYVQAI NFPTVSRGTE RLRITPTPGH 450
TNDLSDILIA AVDDVFNELQ LPRIRDWEMQ GGLLGVGDKN FVPEPNLWTE 500
EQLSFSNEDL NSNVFEPVID QLEVSSGVKL 530
Length:530
Mass (Da):58,385
Last modified:July 19, 2004 - v1
Checksum:i0C5F159D8408A5D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380948 Genomic DNA. Translation: CAG57984.1.
RefSeqiXP_445084.1. XM_445084.1.

Genome annotation databases

GeneIDi2886690.
KEGGicgr:CAGL0B02607g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380948 Genomic DNA. Translation: CAG57984.1 .
RefSeqi XP_445084.1. XM_445084.1.

3D structure databases

ProteinModelPortali Q6FXE3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2886690.
KEGGi cgr:CAGL0B02607g.

Phylogenomic databases

HOGENOMi HOG000221020.
KOi K00643.
OMAi HYLQSIN.
OrthoDBi EOG7HHX1P.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00375 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiHEM1_CANGA
AccessioniPrimary (citable) accession number: Q6FXE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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