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Q6FXE3

- HEM1_CANGA

UniProt

Q6FXE3 - HEM1_CANGA

Protein

5-aminolevulinate synthase, mitochondrial

Gene

HEM1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei73 – 731SubstrateBy similarity
    Binding sitei186 – 1861SubstrateBy similarity
    Binding sitei205 – 2051SubstrateBy similarity
    Binding sitei238 – 2381Pyridoxal phosphateBy similarity
    Binding sitei266 – 2661Pyridoxal phosphateBy similarity
    Binding sitei316 – 3161Pyridoxal phosphateBy similarity
    Active sitei319 – 3191By similarity
    Binding sitei348 – 3481Pyridoxal phosphateBy similarity
    Binding sitei349 – 3491Pyridoxal phosphateBy similarity
    Binding sitei434 – 4341SubstrateBy similarity

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthase, mitochondrial (EC:2.3.1.37)
    Alternative name(s):
    5-aminolevulinic acid synthase
    Delta-ALA synthase
    Delta-aminolevulinate synthase
    Gene namesi
    Name:HEM1
    Ordered Locus Names:CAGL0B02607g
    OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
    Taxonomic identifieri284593 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
    ProteomesiUP000002428: Chromosome B

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 5305-aminolevulinate synthase, mitochondrialPRO_0000001238
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei319 – 3191N6-(pyridoxal phosphate)lysineBy similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6FXE3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOGENOMiHOG000221020.
    KOiK00643.
    OMAiHYLQSIN.
    OrthoDBiEOG7HHX1P.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6FXE3-1 [UniParc]FASTAAdd to Basket

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    MFRPVLKVRP SFSYPYSIVS SRSVRLASTA TANANTAAAT STVAAHGTQE    50
    TPFDFEGHFE SELAKKRLDK SYRYFNNINR LAKEFPLAHR QLEDDKVTVW 100
    CSNDYLALSK NPQVLDAMRK TIDKYGAGAG GTRNIAGHNI PTMRLEAELA 150
    ALHKKEGALV FSSCYVANDA VISLLGQKVK DLVIFSDELN HASMIVGIKH 200
    ANRPKHIFRH NDLAQLEEML QMYPKSTPKL IAFESVYSMA GSVADINKIC 250
    DLAEKYGALT FLDEVHAVGL YGPHGAGVAE HCDFEAHRVA GIATPPQGDN 300
    GRLRTVMDRV DMITGTLGKS FGTVGGYVAA SSKLIDWVRS YAPGFIFTTT 350
    LPPAVMAGAA EAIRFQRSHL NLRQDQQRHT AYVKKGLHDL GIPVIPNPSH 400
    IVPVLIGNPD LAKQASDILM EKHRIYVQAI NFPTVSRGTE RLRITPTPGH 450
    TNDLSDILIA AVDDVFNELQ LPRIRDWEMQ GGLLGVGDKN FVPEPNLWTE 500
    EQLSFSNEDL NSNVFEPVID QLEVSSGVKL 530
    Length:530
    Mass (Da):58,385
    Last modified:July 19, 2004 - v1
    Checksum:i0C5F159D8408A5D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380948 Genomic DNA. Translation: CAG57984.1.
    RefSeqiXP_445084.1. XM_445084.1.

    Genome annotation databases

    GeneIDi2886690.
    KEGGicgr:CAGL0B02607g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380948 Genomic DNA. Translation: CAG57984.1 .
    RefSeqi XP_445084.1. XM_445084.1.

    3D structure databases

    ProteinModelPortali Q6FXE3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2886690.
    KEGGi cgr:CAGL0B02607g.

    Phylogenomic databases

    HOGENOMi HOG000221020.
    KOi K00643.
    OMAi HYLQSIN.
    OrthoDBi EOG7HHX1P.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiHEM1_CANGA
    AccessioniPrimary (citable) accession number: Q6FXE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3