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Q6FWS8

- SDHB_CANGA

UniProt

Q6FWS8 - SDHB_CANGA

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Protein
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Gene
SDH2, CAGL0C03223g
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Binds 1 2Fe-2S cluster By similarity.
Binds 1 3Fe-4S cluster By similarity.
Binds 1 4Fe-4S cluster By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi74 – 741Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi79 – 791Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi82 – 821Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi94 – 941Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi166 – 1661Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi169 – 1691Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi172 – 1721Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi176 – 1761Iron-sulfur 3 (3Fe-4S) By similarity
Binding sitei181 – 1811Ubiquinone; shared with DHSD By similarity
Metal bindingi223 – 2231Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi229 – 2291Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi233 – 2331Iron-sulfur 2 (4Fe-4S) By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  4. electron carrier activity Source: InterPro
  5. metal ion binding Source: UniProtKB-KW
  6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:SDH2
Ordered Locus Names:CAGL0C03223g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
ProteomesiUP000002428: Chromosome C

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 253Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000010348
Transit peptidei1 – ?Mitochondrion

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6FWS8.
SMRiQ6FWS8. Positions 16-251.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 114922Fe-2S ferredoxin-type
Add
BLAST
Domaini156 – 186314Fe-4S ferredoxin-type
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000160590.
KOiK00235.
OMAiRERICGS.
OrthoDBiEOG7X9GJ0.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6FWS8-1 [UniParc]FASTAAdd to Basket

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MFMLRVSRRG LATATSVPRL KTFKIYRWNP DKPTEKPHLQ EYKVDLEDCG    50
PMVLDALLKI KNEQDATLTF RRSCREGICG SCAMNIGGAN TLACLCKIDQ 100
DESKTTKIYP LPHMFIVKDL VPDLTGFYQQ YKSIQPYLQR TDYPADGKEV 150
LQSIDDRKKL DGLYECILCA CCSTSCPSYW WNQEEYLGPA VLMQAYRWLI 200
DSRDQATKAR RTMLQNSMSL YRCHTIMNCT RTCPKGLNPG RSIAEIKKQL 250
AFD 253
Length:253
Mass (Da):29,054
Last modified:July 19, 2004 - v1
Checksum:i2557E1940B402EA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380949 Genomic DNA. Translation: CAG58222.1.
RefSeqiXP_445316.1. XM_445316.1.

Genome annotation databases

GeneIDi2886893.
KEGGicgr:CAGL0C03223g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380949 Genomic DNA. Translation: CAG58222.1 .
RefSeqi XP_445316.1. XM_445316.1.

3D structure databases

ProteinModelPortali Q6FWS8.
SMRi Q6FWS8. Positions 16-251.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2886893.
KEGGi cgr:CAGL0C03223g.

Phylogenomic databases

HOGENOMi HOG000160590.
KOi K00235.
OMAi RERICGS.
OrthoDBi EOG7X9GJ0.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view ]
Pfami PF13085. Fer2_3. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR00384. dhsB. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiSDHB_CANGA
AccessioniPrimary (citable) accession number: Q6FWS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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