Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6FWS8 (SDHB_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

EC=1.3.5.1
Alternative name(s):
Iron-sulfur subunit of complex II
Short name=Ip
Gene names
Name:SDH2
Ordered Locus Names:CAGL0C03223g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces

Protein attributes

Sequence length253 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 1 3Fe-4S cluster By similarity.

Binds 1 4Fe-4S cluster By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Subunit structure

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion
Chain? – 253Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000010348

Regions

Domain23 – 114922Fe-2S ferredoxin-type
Domain156 – 186314Fe-4S ferredoxin-type

Sites

Metal binding741Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding791Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding821Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding941Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1661Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1691Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1721Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1761Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2231Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2291Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2331Iron-sulfur 2 (4Fe-4S) By similarity
Binding site1811Ubiquinone; shared with DHSD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FWS8 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 2557E1940B402EA3

FASTA25329,054
        10         20         30         40         50         60 
MFMLRVSRRG LATATSVPRL KTFKIYRWNP DKPTEKPHLQ EYKVDLEDCG PMVLDALLKI 

        70         80         90        100        110        120 
KNEQDATLTF RRSCREGICG SCAMNIGGAN TLACLCKIDQ DESKTTKIYP LPHMFIVKDL 

       130        140        150        160        170        180 
VPDLTGFYQQ YKSIQPYLQR TDYPADGKEV LQSIDDRKKL DGLYECILCA CCSTSCPSYW 

       190        200        210        220        230        240 
WNQEEYLGPA VLMQAYRWLI DSRDQATKAR RTMLQNSMSL YRCHTIMNCT RTCPKGLNPG 

       250 
RSIAEIKKQL AFD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR380949 Genomic DNA. Translation: CAG58222.1.
RefSeqXP_445316.1. XM_445316.1.

3D structure databases

ProteinModelPortalQ6FWS8.
SMRQ6FWS8. Positions 16-251.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2886893.
KEGGcgr:CAGL0C03223g.

Phylogenomic databases

HOGENOMHOG000160590.
KOK00235.
OMARERICGS.
OrthoDBEOG7X9GJ0.

Enzyme and pathway databases

UniPathwayUPA00223; UER01006.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHB_CANGA
AccessionPrimary (citable) accession number: Q6FWS8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways