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Q6FWJ7

- GPD2_CANGA

UniProt

Q6FWJ7 - GPD2_CANGA

Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)] 2

Gene

GPD2

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei157 – 1571NADBy similarity
    Binding sitei180 – 1801NAD; via amide nitrogenBy similarity
    Binding sitei180 – 1801SubstrateBy similarity
    Binding sitei213 – 2131NAD; via amide nitrogenBy similarity
    Active sitei273 – 2731Proton acceptorBy similarity
    Binding sitei338 – 3381NADBy similarity
    Binding sitei367 – 3671NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi69 – 746NADBy similarity

    GO - Molecular functioni

    1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. glycerol-3-phosphate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol-3-phosphate dehydrogenase [NAD(+)] 2 (EC:1.1.1.8)
    Gene namesi
    Name:GPD2
    Ordered Locus Names:CAGL0C05137g
    OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
    Taxonomic identifieri284593 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
    ProteomesiUP000002428: Chromosome C

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: CGD
    2. glycerol-3-phosphate dehydrogenase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422Glycerol-3-phosphate dehydrogenase [NAD(+)] 2PRO_0000138087Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6FWJ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni338 – 3392Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000246855.
    KOiK00006.
    OMAiPVGEFIH.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR017751. G3P_DH_NAD-dep_euk.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11728. PTHR11728. 1 hit.
    PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSiPR00077. GPDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
    PROSITEiPS00957. NAD_G3PDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6FWJ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFVRLARIPR ITRHYRLGLF STQPKPKPNE YLYYRNKHKS KMEAPIKRSS    50
    SAVSLVELER EPFKVTVIGS GNWGTTIAKV VAENTKANPQ VFQERVDMWV 100
    FDENIDGTML TEIINTKHQN VKYLPNIDLP ENLVANPDLL KSVEGADILV 150
    FNIPHQFLPK IVDQLRGHVE PHVRAISCLK GFEVGKKGVQ LLSTYITEEL 200
    GIECGALSGA NLAPEVAKEH WSETTVAYHI PKDYQGDGMD VDHKVLKLLF 250
    HRPYFHVSVI DDVAGISIAG ALKNVVALGC GFVEGLGWGN NAAAAIQRVG 300
    LGEIIKFGQM FFPESRVETY YQESAGVADL ITTCSGGRNV RVATHMAKTG 350
    KSAEDSEKEL LNGQSAQGVI TCKEVHEWLS TCEMIEEFPL FEAVYKIVYE 400
    DVPMHKLPEM IEELDDIVVA GQ 422
    Length:422
    Mass (Da):47,005
    Last modified:July 19, 2004 - v1
    Checksum:i4BDF81C8757F3EB9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380949 Genomic DNA. Translation: CAG58303.1.
    RefSeqiXP_445397.1. XM_445397.1.

    Genome annotation databases

    GeneIDi2886789.
    KEGGicgr:CAGL0C05137g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380949 Genomic DNA. Translation: CAG58303.1 .
    RefSeqi XP_445397.1. XM_445397.1.

    3D structure databases

    ProteinModelPortali Q6FWJ7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2886789.
    KEGGi cgr:CAGL0C05137g.

    Phylogenomic databases

    HOGENOMi HOG000246855.
    KOi K00006.
    OMAi PVGEFIH.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR017751. G3P_DH_NAD-dep_euk.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11728. PTHR11728. 1 hit.
    Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSi PR00077. GPDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
    PROSITEi PS00957. NAD_G3PDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiGPD2_CANGA
    AccessioniPrimary (citable) accession number: Q6FWJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3