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Q6FWJ7

- GPD2_CANGA

UniProt

Q6FWJ7 - GPD2_CANGA

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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)] 2

Gene

GPD2

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei157 – 1571NADBy similarity
Binding sitei180 – 1801NAD; via amide nitrogenBy similarity
Binding sitei180 – 1801SubstrateBy similarity
Binding sitei213 – 2131NAD; via amide nitrogenBy similarity
Active sitei273 – 2731Proton acceptorBy similarity
Binding sitei338 – 3381NADBy similarity
Binding sitei367 – 3671NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 746NADBy similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2 (EC:1.1.1.8)
Gene namesi
Name:GPD2
Ordered Locus Names:CAGL0C05137g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome C

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: CGD
  2. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Glycerol-3-phosphate dehydrogenase [NAD(+)] 2PRO_0000138087Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6FWJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni338 – 3392Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000246855.
InParanoidiQ6FWJ7.
KOiK00006.
OMAiPVGEFIH.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FWJ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFVRLARIPR ITRHYRLGLF STQPKPKPNE YLYYRNKHKS KMEAPIKRSS
60 70 80 90 100
SAVSLVELER EPFKVTVIGS GNWGTTIAKV VAENTKANPQ VFQERVDMWV
110 120 130 140 150
FDENIDGTML TEIINTKHQN VKYLPNIDLP ENLVANPDLL KSVEGADILV
160 170 180 190 200
FNIPHQFLPK IVDQLRGHVE PHVRAISCLK GFEVGKKGVQ LLSTYITEEL
210 220 230 240 250
GIECGALSGA NLAPEVAKEH WSETTVAYHI PKDYQGDGMD VDHKVLKLLF
260 270 280 290 300
HRPYFHVSVI DDVAGISIAG ALKNVVALGC GFVEGLGWGN NAAAAIQRVG
310 320 330 340 350
LGEIIKFGQM FFPESRVETY YQESAGVADL ITTCSGGRNV RVATHMAKTG
360 370 380 390 400
KSAEDSEKEL LNGQSAQGVI TCKEVHEWLS TCEMIEEFPL FEAVYKIVYE
410 420
DVPMHKLPEM IEELDDIVVA GQ
Length:422
Mass (Da):47,005
Last modified:July 19, 2004 - v1
Checksum:i4BDF81C8757F3EB9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380949 Genomic DNA. Translation: CAG58303.1.
RefSeqiXP_445397.1. XM_445397.1.

Genome annotation databases

GeneIDi2886789.
KEGGicgr:CAGL0C05137g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380949 Genomic DNA. Translation: CAG58303.1 .
RefSeqi XP_445397.1. XM_445397.1.

3D structure databases

ProteinModelPortali Q6FWJ7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2886789.
KEGGi cgr:CAGL0C05137g.

Phylogenomic databases

HOGENOMi HOG000246855.
InParanoidi Q6FWJ7.
KOi K00006.
OMAi PVGEFIH.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiGPD2_CANGA
AccessioniPrimary (citable) accession number: Q6FWJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3