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Q6FWD1 (ALG11_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

EC=2.4.1.131
Alternative name(s):
Alpha-1,2-mannosyltransferase ALG11
Asparagine-linked glycosylation protein 11
Glycolipid 2-alpha-mannosyltransferase
Gene names
Name:ALG11
Ordered Locus Names:CAGL0D01122g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum By similarity.

Catalytic activity

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase group 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 505505GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
PRO_0000080274

Regions

Topological domain1 – 44Cytoplasmic Potential
Transmembrane5 – 2521Helical; Signal-anchor for type II membrane protein; Potential
Topological domain26 – 505480Lumenal Potential

Amino acid modifications

Glycosylation781N-linked (GlcNAc...) Potential
Glycosylation2331N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6FWD1 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 063A7B3A65B0B43B

FASTA50558,084
        10         20         30         40         50         60 
MSTMLWVVVA AVLLFVLPVV RVPMLDLTRR NIIRWQRGGI QKYTTRYYGF FHPYCNAGGG 

        70         80         90        100        110        120 
GEKVLWKAVQ ETLLYDPNCS IVIYTGDVDS SPKEIIANVI KRFDYEMDFN RVQFVFLKYR 

       130        140        150        160        170        180 
KWVDGSTWKH LTLVGQAMGS MLLTIEALLR FVPDIWLDTM GYPFGYPVVR WLAGLPVMTY 

       190        200        210        220        230        240 
THYPVISSDM IHKIEIENQK QPSKKGTLKL IYWKLFMKWY QYVGKFVDVA ITNSTWTGNH 

       250        260        270        280        290        300 
IRSIWKRVKI KVMYPPCSTE KLVKNSSPTA YETRQNQAVL IAQFRPEKRH KLVIQAYSDF 

       310        320        330        340        350        360 
ISRTASKDHF KLVLIGSTRS EEDRAYVETL KSWAFDTLKI PKESLTFKTD CSYDDIKKFL 

       370        380        390        400        410        420 
AESTFGINAM WNEHFGIAVV EYAAAGLISL VHASAGPLLD IIVPWDSAKK QQLPYSDSTK 

       430        440        450        460        470        480 
DTRTGLFFKD KSDPDYKPTD AQFNNYGSLA DIFEEANSLS IAERKQISER AKECASNKFS 

       490        500 
DNTFNHAWDH ALDELEHKTS RLGSN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR380950 Genomic DNA. Translation: CAG58374.1.
RefSeqXP_445463.1. XM_445463.1.

3D structure databases

ProteinModelPortalQ6FWD1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2887168.
KEGGcgr:CAGL0D01122g.

Phylogenomic databases

HOGENOMHOG000209670.
KOK03844.
OMASEDSYAA.
OrthoDBEOG7673KQ.

Enzyme and pathway databases

UniPathwayUPA00378.

Family and domain databases

InterProIPR001296. Glyco_trans_1.
[Graphical view]
PfamPF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALG11_CANGA
AccessionPrimary (citable) accession number: Q6FWD1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways