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Q6FWD1

- ALG11_CANGA

UniProt

Q6FWD1 - ALG11_CANGA

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Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene

ALG11

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum (By similarity).By similarity

Catalytic activityi

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

Pathwayi

GO - Molecular functioni

  1. GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
Alternative name(s):
Alpha-1,2-mannosyltransferase ALG11
Asparagine-linked glycosylation protein 11
Glycolipid 2-alpha-mannosyltransferase
Gene namesi
Name:ALG11
Ordered Locus Names:CAGL0D01122g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome D

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44CytoplasmicSequence Analysis
Transmembranei5 – 2521Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini26 – 505480LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferasePRO_0000080274Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi233 – 2331N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ6FWD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000209670.
InParanoidiQ6FWD1.
KOiK03844.
OMAiSEDSYAA.
OrthoDBiEOG7673KQ.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FWD1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTMLWVVVA AVLLFVLPVV RVPMLDLTRR NIIRWQRGGI QKYTTRYYGF
60 70 80 90 100
FHPYCNAGGG GEKVLWKAVQ ETLLYDPNCS IVIYTGDVDS SPKEIIANVI
110 120 130 140 150
KRFDYEMDFN RVQFVFLKYR KWVDGSTWKH LTLVGQAMGS MLLTIEALLR
160 170 180 190 200
FVPDIWLDTM GYPFGYPVVR WLAGLPVMTY THYPVISSDM IHKIEIENQK
210 220 230 240 250
QPSKKGTLKL IYWKLFMKWY QYVGKFVDVA ITNSTWTGNH IRSIWKRVKI
260 270 280 290 300
KVMYPPCSTE KLVKNSSPTA YETRQNQAVL IAQFRPEKRH KLVIQAYSDF
310 320 330 340 350
ISRTASKDHF KLVLIGSTRS EEDRAYVETL KSWAFDTLKI PKESLTFKTD
360 370 380 390 400
CSYDDIKKFL AESTFGINAM WNEHFGIAVV EYAAAGLISL VHASAGPLLD
410 420 430 440 450
IIVPWDSAKK QQLPYSDSTK DTRTGLFFKD KSDPDYKPTD AQFNNYGSLA
460 470 480 490 500
DIFEEANSLS IAERKQISER AKECASNKFS DNTFNHAWDH ALDELEHKTS

RLGSN
Length:505
Mass (Da):58,084
Last modified:July 19, 2004 - v1
Checksum:i063A7B3A65B0B43B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380950 Genomic DNA. Translation: CAG58374.1.
RefSeqiXP_445463.1. XM_445463.1.

Genome annotation databases

GeneIDi2887168.
KEGGicgr:CAGL0D01122g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380950 Genomic DNA. Translation: CAG58374.1 .
RefSeqi XP_445463.1. XM_445463.1.

3D structure databases

ProteinModelPortali Q6FWD1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2887168.
KEGGi cgr:CAGL0D01122g.

Phylogenomic databases

HOGENOMi HOG000209670.
InParanoidi Q6FWD1.
KOi K03844.
OMAi SEDSYAA.
OrthoDBi EOG7673KQ.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Family and domain databases

InterProi IPR001296. Glyco_trans_1.
[Graphical view ]
Pfami PF00534. Glycos_transf_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiALG11_CANGA
AccessioniPrimary (citable) accession number: Q6FWD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3