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Q6FW88

- PMIP_CANGA

UniProt

Q6FW88 - PMIP_CANGA

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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi547 – 5471Zinc; catalyticPROSITE-ProRule annotation
Active sitei548 – 5481PROSITE-ProRule annotation
Metal bindingi551 – 5511Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi554 – 5541Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Ordered Locus Names:CAGL0D02112g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome D

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3737MitochondrionSequence AnalysisAdd
BLAST
Chaini38 – 761724Mitochondrial intermediate peptidasePRO_0000338577Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6FW88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000076521.
InParanoidiQ6FW88.
KOiK01410.
OMAiLQVFYSA.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6FW88-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLIQKILLNK EISRLPRILS ILNYTGLRWL SGSSGRNTTE LQRIFDDSKY
60 70 80 90 100
WQSLSENTTQ YTKETGLFKN PYLTSTDGLR QFSHDSLHKA HKLAEILRNS
110 120 130 140 150
VSKEEKVHYI MNLDQLSDTL CRVIDLCEFL RSAHPDQSYV EAAQMCHEEM
160 170 180 190 200
FEFMNVLNTD VVLCNKLKEV LEDPEILKVL SEEERKVGEI LLDDFEKSGI
210 220 230 240 250
YMKAGIREQF IELSQQISVI GQEFINNTDY VAKEFIKVKR DEMDKSGISP
260 270 280 290 300
LLTARLNRDL TGKYYKIPTY GQIPLQILKS CPDEDIRKEV WAALHNCPKA
310 320 330 340 350
QIQRLNQLVR LRVILSNLLG KQSYSDYQLD NKMAGSPENV KGFIKTLMNV
360 370 380 390 400
TKPLAARELE FIARDKLNAP DSRHMSDNEI LSIVKPWDKN YFSSKYDSDN
410 420 430 440 450
EMAMIRDEQL RYYFSLGNVI NGLSELFKRI YGITLQPSRT ENGETWSPDV
460 470 480 490 500
RRLDVISEEE GLVGVIYCDL FERVGKISNP AHFTVCCSRQ VYPDENDFTT
510 520 530 540 550
IQTGQNSDGT VFQLPVISLV CNFSTVALPN GNRTCFLHMN EIETLFHEMG
560 570 580 590 600
HAMHSMLGRT RLQNISGTRC ATDFVELPSI LMEHFARDIR VLRTIGSHYE
610 620 630 640 650
TSEPAPEALL NDYLDKTQFL QHCETYSQAK MAMLDQKLHG SFSLSDIERI
660 670 680 690 700
DSAKIYQKLE TRLQVLADDE SNWCGRFGHL FGYGATYYSY LFDRAIASKV
710 720 730 740 750
WDSLFKDDPF NRTGGEKFKE RVLKWGGLKN PWSCIADVLE KPDLAKGGAE
760
AMTYIGDSED L
Length:761
Mass (Da):87,333
Last modified:July 19, 2004 - v1
Checksum:i89CA8567A26EC72E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380950 Genomic DNA. Translation: CAG58417.1.
RefSeqiXP_445506.1. XM_445506.1.

Genome annotation databases

GeneIDi2887167.
KEGGicgr:CAGL0D02112g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380950 Genomic DNA. Translation: CAG58417.1 .
RefSeqi XP_445506.1. XM_445506.1.

3D structure databases

ProteinModelPortali Q6FW88.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2887167.
KEGGi cgr:CAGL0D02112g.

Phylogenomic databases

HOGENOMi HOG000076521.
InParanoidi Q6FW88.
KOi K01410.
OMAi LQVFYSA.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiPMIP_CANGA
AccessioniPrimary (citable) accession number: Q6FW88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3