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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi547Zinc; catalyticPROSITE-ProRule annotation1
Active sitei548PROSITE-ProRule annotation1
Metal bindingi551Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi554Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Ordered Locus Names:CAGL0D02112g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome D

Organism-specific databases

CGDiCAL0128069. CAGL0D02112g.
EuPathDBiFungiDB:CAGL0D02112g.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 37MitochondrionSequence analysisAdd BLAST37
ChainiPRO_000033857738 – 761Mitochondrial intermediate peptidaseAdd BLAST724

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_445506.1.

Structurei

3D structure databases

ProteinModelPortaliQ6FW88.
SMRiQ6FW88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2090. Eukaryota.
COG0339. LUCA.
HOGENOMiHOG000076521.
InParanoidiQ6FW88.
KOiK01410.
OMAiVENTAWQ.
OrthoDBiEOG092C0JU2.

Family and domain databases

CDDicd06457. M3A_MIP. 1 hit.
Gene3Di1.20.1050.40. 1 hit.
InterProiView protein in InterPro
IPR033851. M3A_MIP.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
PANTHERiPTHR11804:SF5. PTHR11804:SF5. 1 hit.
PfamiView protein in Pfam
PF01432. Peptidase_M3. 1 hit.
PROSITEiView protein in PROSITE
PS00142. ZINC_PROTEASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6FW88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIQKILLNK EISRLPRILS ILNYTGLRWL SGSSGRNTTE LQRIFDDSKY
60 70 80 90 100
WQSLSENTTQ YTKETGLFKN PYLTSTDGLR QFSHDSLHKA HKLAEILRNS
110 120 130 140 150
VSKEEKVHYI MNLDQLSDTL CRVIDLCEFL RSAHPDQSYV EAAQMCHEEM
160 170 180 190 200
FEFMNVLNTD VVLCNKLKEV LEDPEILKVL SEEERKVGEI LLDDFEKSGI
210 220 230 240 250
YMKAGIREQF IELSQQISVI GQEFINNTDY VAKEFIKVKR DEMDKSGISP
260 270 280 290 300
LLTARLNRDL TGKYYKIPTY GQIPLQILKS CPDEDIRKEV WAALHNCPKA
310 320 330 340 350
QIQRLNQLVR LRVILSNLLG KQSYSDYQLD NKMAGSPENV KGFIKTLMNV
360 370 380 390 400
TKPLAARELE FIARDKLNAP DSRHMSDNEI LSIVKPWDKN YFSSKYDSDN
410 420 430 440 450
EMAMIRDEQL RYYFSLGNVI NGLSELFKRI YGITLQPSRT ENGETWSPDV
460 470 480 490 500
RRLDVISEEE GLVGVIYCDL FERVGKISNP AHFTVCCSRQ VYPDENDFTT
510 520 530 540 550
IQTGQNSDGT VFQLPVISLV CNFSTVALPN GNRTCFLHMN EIETLFHEMG
560 570 580 590 600
HAMHSMLGRT RLQNISGTRC ATDFVELPSI LMEHFARDIR VLRTIGSHYE
610 620 630 640 650
TSEPAPEALL NDYLDKTQFL QHCETYSQAK MAMLDQKLHG SFSLSDIERI
660 670 680 690 700
DSAKIYQKLE TRLQVLADDE SNWCGRFGHL FGYGATYYSY LFDRAIASKV
710 720 730 740 750
WDSLFKDDPF NRTGGEKFKE RVLKWGGLKN PWSCIADVLE KPDLAKGGAE
760
AMTYIGDSED L
Length:761
Mass (Da):87,333
Last modified:July 19, 2004 - v1
Checksum:i89CA8567A26EC72E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380950 Genomic DNA. Translation: CAG58417.1.
RefSeqiXP_445506.1. XM_445506.1.

Genome annotation databases

EnsemblFungiiCAG58417; CAG58417; CAGL0D02112g.
GeneIDi2887167.
KEGGicgr:CAGL0D02112g.

Similar proteinsi

Entry informationi

Entry nameiPMIP_CANGA
AccessioniPrimary (citable) accession number: Q6FW88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 19, 2004
Last modified: October 25, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families