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Q6FW88

- PMIP_CANGA

UniProt

Q6FW88 - PMIP_CANGA

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi547 – 5471Zinc; catalyticPROSITE-ProRule annotation
    Active sitei548 – 5481PROSITE-ProRule annotation
    Metal bindingi551 – 5511Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi554 – 5541Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    Ordered Locus Names:CAGL0D02112g
    OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
    Taxonomic identifieri284593 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
    ProteomesiUP000002428: Chromosome D

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3737MitochondrionSequence AnalysisAdd
    BLAST
    Chaini38 – 761724Mitochondrial intermediate peptidasePRO_0000338577Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6FW88.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOGENOMiHOG000076521.
    KOiK01410.
    OMAiLQVFYSA.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    3.40.390.10. 1 hit.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6FW88-1 [UniParc]FASTAAdd to Basket

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    MLIQKILLNK EISRLPRILS ILNYTGLRWL SGSSGRNTTE LQRIFDDSKY    50
    WQSLSENTTQ YTKETGLFKN PYLTSTDGLR QFSHDSLHKA HKLAEILRNS 100
    VSKEEKVHYI MNLDQLSDTL CRVIDLCEFL RSAHPDQSYV EAAQMCHEEM 150
    FEFMNVLNTD VVLCNKLKEV LEDPEILKVL SEEERKVGEI LLDDFEKSGI 200
    YMKAGIREQF IELSQQISVI GQEFINNTDY VAKEFIKVKR DEMDKSGISP 250
    LLTARLNRDL TGKYYKIPTY GQIPLQILKS CPDEDIRKEV WAALHNCPKA 300
    QIQRLNQLVR LRVILSNLLG KQSYSDYQLD NKMAGSPENV KGFIKTLMNV 350
    TKPLAARELE FIARDKLNAP DSRHMSDNEI LSIVKPWDKN YFSSKYDSDN 400
    EMAMIRDEQL RYYFSLGNVI NGLSELFKRI YGITLQPSRT ENGETWSPDV 450
    RRLDVISEEE GLVGVIYCDL FERVGKISNP AHFTVCCSRQ VYPDENDFTT 500
    IQTGQNSDGT VFQLPVISLV CNFSTVALPN GNRTCFLHMN EIETLFHEMG 550
    HAMHSMLGRT RLQNISGTRC ATDFVELPSI LMEHFARDIR VLRTIGSHYE 600
    TSEPAPEALL NDYLDKTQFL QHCETYSQAK MAMLDQKLHG SFSLSDIERI 650
    DSAKIYQKLE TRLQVLADDE SNWCGRFGHL FGYGATYYSY LFDRAIASKV 700
    WDSLFKDDPF NRTGGEKFKE RVLKWGGLKN PWSCIADVLE KPDLAKGGAE 750
    AMTYIGDSED L 761
    Length:761
    Mass (Da):87,333
    Last modified:July 19, 2004 - v1
    Checksum:i89CA8567A26EC72E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380950 Genomic DNA. Translation: CAG58417.1.
    RefSeqiXP_445506.1. XM_445506.1.

    Genome annotation databases

    GeneIDi2887167.
    KEGGicgr:CAGL0D02112g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380950 Genomic DNA. Translation: CAG58417.1 .
    RefSeqi XP_445506.1. XM_445506.1.

    3D structure databases

    ProteinModelPortali Q6FW88.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2887167.
    KEGGi cgr:CAGL0D02112g.

    Phylogenomic databases

    HOGENOMi HOG000076521.
    KOi K01410.
    OMAi LQVFYSA.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    3.40.390.10. 1 hit.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiPMIP_CANGA
    AccessioniPrimary (citable) accession number: Q6FW88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3