SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6FW88

- PMIP_CANGA

UniProt

Q6FW88 - PMIP_CANGA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Mitochondrial intermediate peptidase

Gene
OCT1, CAGL0D02112g
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi547 – 5471Zinc; catalytic By similarity
Active sitei548 – 5481 By similarity
Metal bindingi551 – 5511Zinc; catalytic By similarity
Metal bindingi554 – 5541Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Ordered Locus Names:CAGL0D02112g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
ProteomesiUP000002428: Chromosome D

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3737Mitochondrion Reviewed predictionAdd
BLAST
Chaini38 – 761724Mitochondrial intermediate peptidasePRO_0000338577Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6FW88.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000076521.
KOiK01410.
OMAiLQVFYSA.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6FW88-1 [UniParc]FASTAAdd to Basket

« Hide

MLIQKILLNK EISRLPRILS ILNYTGLRWL SGSSGRNTTE LQRIFDDSKY    50
WQSLSENTTQ YTKETGLFKN PYLTSTDGLR QFSHDSLHKA HKLAEILRNS 100
VSKEEKVHYI MNLDQLSDTL CRVIDLCEFL RSAHPDQSYV EAAQMCHEEM 150
FEFMNVLNTD VVLCNKLKEV LEDPEILKVL SEEERKVGEI LLDDFEKSGI 200
YMKAGIREQF IELSQQISVI GQEFINNTDY VAKEFIKVKR DEMDKSGISP 250
LLTARLNRDL TGKYYKIPTY GQIPLQILKS CPDEDIRKEV WAALHNCPKA 300
QIQRLNQLVR LRVILSNLLG KQSYSDYQLD NKMAGSPENV KGFIKTLMNV 350
TKPLAARELE FIARDKLNAP DSRHMSDNEI LSIVKPWDKN YFSSKYDSDN 400
EMAMIRDEQL RYYFSLGNVI NGLSELFKRI YGITLQPSRT ENGETWSPDV 450
RRLDVISEEE GLVGVIYCDL FERVGKISNP AHFTVCCSRQ VYPDENDFTT 500
IQTGQNSDGT VFQLPVISLV CNFSTVALPN GNRTCFLHMN EIETLFHEMG 550
HAMHSMLGRT RLQNISGTRC ATDFVELPSI LMEHFARDIR VLRTIGSHYE 600
TSEPAPEALL NDYLDKTQFL QHCETYSQAK MAMLDQKLHG SFSLSDIERI 650
DSAKIYQKLE TRLQVLADDE SNWCGRFGHL FGYGATYYSY LFDRAIASKV 700
WDSLFKDDPF NRTGGEKFKE RVLKWGGLKN PWSCIADVLE KPDLAKGGAE 750
AMTYIGDSED L 761
Length:761
Mass (Da):87,333
Last modified:July 19, 2004 - v1
Checksum:i89CA8567A26EC72E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380950 Genomic DNA. Translation: CAG58417.1.
RefSeqiXP_445506.1. XM_445506.1.

Genome annotation databases

GeneIDi2887167.
KEGGicgr:CAGL0D02112g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380950 Genomic DNA. Translation: CAG58417.1 .
RefSeqi XP_445506.1. XM_445506.1.

3D structure databases

ProteinModelPortali Q6FW88.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M03.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2887167.
KEGGi cgr:CAGL0D02112g.

Phylogenomic databases

HOGENOMi HOG000076521.
KOi K01410.
OMAi LQVFYSA.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiPMIP_CANGA
AccessioniPrimary (citable) accession number: Q6FW88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3