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Protein

Palmitoyltransferase PFA4

Gene

PFA4

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.UniRule annotation

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108S-palmitoyl cysteine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase PFA4UniRule annotation (EC:2.3.1.225UniRule annotation)
Alternative name(s):
Protein S-acyltransferaseUniRule annotation
Short name:
PATUniRule annotation
Protein fatty acyltransferase 4UniRule annotation
Gene namesi
Name:PFA4UniRule annotation
Ordered Locus Names:CAGL0E02497g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome E

Organism-specific databases

CGDiCAL0129088. CAGL0E02497g.
EuPathDBiFungiDB:CAGL0E02497g.

Subcellular locationi

  • Endoplasmic reticulum membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicUniRule annotationAdd BLAST11
Transmembranei12 – 32HelicalUniRule annotationAdd BLAST21
Topological domaini33 – 40LumenalUniRule annotation8
Transmembranei41 – 61HelicalUniRule annotationAdd BLAST21
Topological domaini62 – 122CytoplasmicUniRule annotationAdd BLAST61
Transmembranei123 – 143HelicalUniRule annotationAdd BLAST21
Topological domaini144 – 163LumenalUniRule annotationAdd BLAST20
Transmembranei164 – 184HelicalUniRule annotationAdd BLAST21
Topological domaini185 – 376CytoplasmicUniRule annotationAdd BLAST192

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129631 – 376Palmitoyltransferase PFA4Add BLAST376

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_445798.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 128DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.UniRule annotation

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1314. Eukaryota.
COG5273. LUCA.
HOGENOMiHOG000248636.
InParanoidiQ6FVE6.
KOiK18932.
OMAiLPWPPDG.
OrthoDBiEOG092C4CK8.

Family and domain databases

HAMAPiMF_03199. DHHC_PAT_PFA4. 1 hit.
InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
IPR033682. PFA4.
PfamiView protein in Pfam
PF01529. DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FVE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVKLKWPWL GIAIPSFLIA SIGYCAHYFI LLNFLSLRKQ LWYQFCQTMI
60 70 80 90 100
WLSYYLAIYT PPGKPPTNFK PSKNEWKVYC KKCKCYKPER SHHCKTCNQC
110 120 130 140 150
VLMMDHHCPW TMNCVGYNNF PHFIRFLFWV IVGTTSLAIF LTTRIHSIWV
160 170 180 190 200
HRSSPSYLYY KSELIFLTIL TPLNAFILLT ISILMIRCLF NQIFNGRSQI
210 220 230 240 250
ESWEMDRLET LARMSKLLPI LIENVWYIFP NLRNEHVESQ AEALLNKKRL
260 270 280 290 300
SLDELVNFPY DLGPFRNAIQ LLGTPPLWLY PFSGPQDDGL HFQKNEESMI
310 320 330 340 350
EDPNSLNDII LCLPWPPDST KHLNSTSEHT SNVQIISEEG EQVIRIRTPE
360 370
KKLSRSEWLN DWGESLEDFG VDVDVE
Length:376
Mass (Da):44,136
Last modified:July 19, 2004 - v1
Checksum:i62AF69C23C5AAF33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380951 Genomic DNA. Translation: CAG58717.1.
RefSeqiXP_445798.1. XM_445798.1.

Genome annotation databases

EnsemblFungiiCAG58717; CAG58717; CAGL0E02497g.
GeneIDi2887488.
KEGGicgr:CAGL0E02497g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380951 Genomic DNA. Translation: CAG58717.1.
RefSeqiXP_445798.1. XM_445798.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284593.XP_445798.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG58717; CAG58717; CAGL0E02497g.
GeneIDi2887488.
KEGGicgr:CAGL0E02497g.

Organism-specific databases

CGDiCAL0129088. CAGL0E02497g.
EuPathDBiFungiDB:CAGL0E02497g.

Phylogenomic databases

eggNOGiKOG1314. Eukaryota.
COG5273. LUCA.
HOGENOMiHOG000248636.
InParanoidiQ6FVE6.
KOiK18932.
OMAiLPWPPDG.
OrthoDBiEOG092C4CK8.

Family and domain databases

HAMAPiMF_03199. DHHC_PAT_PFA4. 1 hit.
InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
IPR033682. PFA4.
PfamiView protein in Pfam
PF01529. DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPFA4_CANGA
AccessioniPrimary (citable) accession number: Q6FVE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 19, 2004
Last modified: June 7, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.