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Q6FV12 (KPYK2_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate kinase 2

Short name=PK 2
EC=2.7.1.40
Gene names
Name:PYK2
Ordered Locus Names:CAGL0E05610g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium.

Potassium.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Pyruvate kinase 2
PRO_0000112111

Sites

Metal binding521Potassium By similarity
Metal binding541Potassium By similarity
Metal binding851Potassium By similarity
Metal binding861Potassium; via carbonyl oxygen By similarity
Metal binding2431Magnesium Potential
Metal binding2671Magnesium By similarity
Binding site501Substrate By similarity
Binding site2661Substrate; via amide nitrogen By similarity
Binding site2671Substrate; via amide nitrogen By similarity
Binding site2991Substrate By similarity
Binding site3381ADP Potential
Site2411Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FV12 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 45C66443272EC7B9

FASTA50855,598
        10         20         30         40         50         60 
MDSRLHRLIN LEVTPGKDVR KTAIIGTIGP KTNNVDTLVA LRKAGLNIVR MNFSHGSYEY 

        70         80         90        100        110        120 
HQSVIDNARK SEQVYPGRPL AIALDTKGPE IRTGTNVDDV DYPIPPNHEM IFTTDDKYAK 

       130        140        150        160        170        180 
ACDDKIMYVD YKNITKVIQP GKVIYVDDGV LSFEVLEVVD DKTLKVKSLN AGKISSHKGV 

       190        200        210        220        230        240 
NLPGTDVDLP ALSEKDKEDL RFGVKNGVHM IFASFIRTAQ DVLTIREVLG EEGKDIKVIV 

       250        260        270        280        290        300 
KIENQQGVNN FDEILEVAHG VMVARGDLGI EIPAPQVLAV QKKLIAKCNL AGKPVICATQ 

       310        320        330        340        350        360 
MLESMTFNPR PTRAEVSDVG NAILDGADCV MLSGETAKGN YPINAVTTMA ETAIIAERAI 

       370        380        390        400        410        420 
AYMPLYDDLR NCTPKPTSTT ETVAASAVAA VQEQGAKLIL VLSTSGNTAR LVSKYRPQCP 

       430        440        450        460        470        480 
IVLVTRNPRT ARFSHLFRGV FPFVYEKEPL DDWSEDTHAR LRFGVDMAKE YGFVKNGDAV 

       490        500 
ISIQGFKGGV GHSNTMRVSI VGGEKEDI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR380951 Genomic DNA. Translation: CAG58851.1.
RefSeqXP_445932.1. XM_445932.1.

3D structure databases

ProteinModelPortalQ6FV12.
SMRQ6FV12. Positions 3-501.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ6FV12.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2887537.
KEGGcgr:CAGL0E05610g.

Phylogenomic databases

HOGENOMHOG000021559.
KOK00873.
OMATAMENTC.
OrthoDBEOG7M6DJC.

Enzyme and pathway databases

UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK2_CANGA
AccessionPrimary (citable) accession number: Q6FV12
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 19, 2004
Last modified: November 13, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways