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Q6FV12

- KPYK2_CANGA

UniProt

Q6FV12 - KPYK2_CANGA

Protein

Pyruvate kinase 2

Gene

PYK2

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + pyruvate = ADP + phosphoenolpyruvate.

    Cofactori

    Magnesium.
    Potassium.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei50 – 501SubstrateBy similarity
    Metal bindingi52 – 521PotassiumBy similarity
    Metal bindingi54 – 541PotassiumBy similarity
    Metal bindingi85 – 851PotassiumBy similarity
    Metal bindingi86 – 861Potassium; via carbonyl oxygenBy similarity
    Sitei241 – 2411Transition state stabilizerBy similarity
    Metal bindingi243 – 2431MagnesiumSequence Analysis
    Binding sitei266 – 2661Substrate; via amide nitrogenBy similarity
    Metal bindingi267 – 2671MagnesiumBy similarity
    Binding sitei267 – 2671Substrate; via amide nitrogenBy similarity
    Binding sitei299 – 2991SubstrateBy similarity
    Binding sitei338 – 3381ADPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: InterPro
    3. potassium ion binding Source: InterPro
    4. pyruvate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00188.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate kinase 2 (EC:2.7.1.40)
    Short name:
    PK 2
    Gene namesi
    Name:PYK2
    Ordered Locus Names:CAGL0E05610g
    OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
    Taxonomic identifieri284593 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
    ProteomesiUP000002428: Chromosome E

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508Pyruvate kinase 2PRO_0000112111Add
    BLAST

    Proteomic databases

    PRIDEiQ6FV12.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6FV12.
    SMRiQ6FV12. Positions 3-501.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyruvate kinase family.Curated

    Phylogenomic databases

    HOGENOMiHOG000021559.
    KOiK00873.
    OMAiYAAPGDQ.
    OrthoDBiEOG7M6DJC.

    Family and domain databases

    Gene3Di2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProiIPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view]
    PANTHERiPTHR11817. PTHR11817. 1 hit.
    PfamiPF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view]
    PRINTSiPR01050. PYRUVTKNASE.
    SUPFAMiSSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
    PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6FV12-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSRLHRLIN LEVTPGKDVR KTAIIGTIGP KTNNVDTLVA LRKAGLNIVR    50
    MNFSHGSYEY HQSVIDNARK SEQVYPGRPL AIALDTKGPE IRTGTNVDDV 100
    DYPIPPNHEM IFTTDDKYAK ACDDKIMYVD YKNITKVIQP GKVIYVDDGV 150
    LSFEVLEVVD DKTLKVKSLN AGKISSHKGV NLPGTDVDLP ALSEKDKEDL 200
    RFGVKNGVHM IFASFIRTAQ DVLTIREVLG EEGKDIKVIV KIENQQGVNN 250
    FDEILEVAHG VMVARGDLGI EIPAPQVLAV QKKLIAKCNL AGKPVICATQ 300
    MLESMTFNPR PTRAEVSDVG NAILDGADCV MLSGETAKGN YPINAVTTMA 350
    ETAIIAERAI AYMPLYDDLR NCTPKPTSTT ETVAASAVAA VQEQGAKLIL 400
    VLSTSGNTAR LVSKYRPQCP IVLVTRNPRT ARFSHLFRGV FPFVYEKEPL 450
    DDWSEDTHAR LRFGVDMAKE YGFVKNGDAV ISIQGFKGGV GHSNTMRVSI 500
    VGGEKEDI 508
    Length:508
    Mass (Da):55,598
    Last modified:July 19, 2004 - v1
    Checksum:i45C66443272EC7B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380951 Genomic DNA. Translation: CAG58851.1.
    RefSeqiXP_445932.1. XM_445932.1.

    Genome annotation databases

    GeneIDi2887537.
    KEGGicgr:CAGL0E05610g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380951 Genomic DNA. Translation: CAG58851.1 .
    RefSeqi XP_445932.1. XM_445932.1.

    3D structure databases

    ProteinModelPortali Q6FV12.
    SMRi Q6FV12. Positions 3-501.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6FV12.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2887537.
    KEGGi cgr:CAGL0E05610g.

    Phylogenomic databases

    HOGENOMi HOG000021559.
    KOi K00873.
    OMAi YAAPGDQ.
    OrthoDBi EOG7M6DJC.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00188 .

    Family and domain databases

    Gene3Di 2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProi IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view ]
    PANTHERi PTHR11817. PTHR11817. 1 hit.
    Pfami PF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01050. PYRUVTKNASE.
    SUPFAMi SSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
    PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiKPYK2_CANGA
    AccessioniPrimary (citable) accession number: Q6FV12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3