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Q6FV12

- KPYK2_CANGA

UniProt

Q6FV12 - KPYK2_CANGA

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Protein

Pyruvate kinase 2

Gene

PYK2

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium.
Potassium.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501SubstrateBy similarity
Metal bindingi52 – 521PotassiumBy similarity
Metal bindingi54 – 541PotassiumBy similarity
Metal bindingi85 – 851PotassiumBy similarity
Metal bindingi86 – 861Potassium; via carbonyl oxygenBy similarity
Sitei241 – 2411Transition state stabilizerBy similarity
Metal bindingi243 – 2431MagnesiumSequence Analysis
Binding sitei266 – 2661Substrate; via amide nitrogenBy similarity
Metal bindingi267 – 2671MagnesiumBy similarity
Binding sitei267 – 2671Substrate; via amide nitrogenBy similarity
Binding sitei299 – 2991SubstrateBy similarity
Binding sitei338 – 3381ADPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase 2 (EC:2.7.1.40)
Short name:
PK 2
Gene namesi
Name:PYK2
Ordered Locus Names:CAGL0E05610g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome E

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Pyruvate kinase 2PRO_0000112111Add
BLAST

Proteomic databases

PRIDEiQ6FV12.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6FV12.
SMRiQ6FV12. Positions 3-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.Curated

Phylogenomic databases

HOGENOMiHOG000021559.
InParanoidiQ6FV12.
KOiK00873.
OMAiYAAPGDQ.
OrthoDBiEOG7M6DJC.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FV12-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSRLHRLIN LEVTPGKDVR KTAIIGTIGP KTNNVDTLVA LRKAGLNIVR
60 70 80 90 100
MNFSHGSYEY HQSVIDNARK SEQVYPGRPL AIALDTKGPE IRTGTNVDDV
110 120 130 140 150
DYPIPPNHEM IFTTDDKYAK ACDDKIMYVD YKNITKVIQP GKVIYVDDGV
160 170 180 190 200
LSFEVLEVVD DKTLKVKSLN AGKISSHKGV NLPGTDVDLP ALSEKDKEDL
210 220 230 240 250
RFGVKNGVHM IFASFIRTAQ DVLTIREVLG EEGKDIKVIV KIENQQGVNN
260 270 280 290 300
FDEILEVAHG VMVARGDLGI EIPAPQVLAV QKKLIAKCNL AGKPVICATQ
310 320 330 340 350
MLESMTFNPR PTRAEVSDVG NAILDGADCV MLSGETAKGN YPINAVTTMA
360 370 380 390 400
ETAIIAERAI AYMPLYDDLR NCTPKPTSTT ETVAASAVAA VQEQGAKLIL
410 420 430 440 450
VLSTSGNTAR LVSKYRPQCP IVLVTRNPRT ARFSHLFRGV FPFVYEKEPL
460 470 480 490 500
DDWSEDTHAR LRFGVDMAKE YGFVKNGDAV ISIQGFKGGV GHSNTMRVSI

VGGEKEDI
Length:508
Mass (Da):55,598
Last modified:July 19, 2004 - v1
Checksum:i45C66443272EC7B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380951 Genomic DNA. Translation: CAG58851.1.
RefSeqiXP_445932.1. XM_445932.1.

Genome annotation databases

GeneIDi2887537.
KEGGicgr:CAGL0E05610g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380951 Genomic DNA. Translation: CAG58851.1 .
RefSeqi XP_445932.1. XM_445932.1.

3D structure databases

ProteinModelPortali Q6FV12.
SMRi Q6FV12. Positions 3-501.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6FV12.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2887537.
KEGGi cgr:CAGL0E05610g.

Phylogenomic databases

HOGENOMi HOG000021559.
InParanoidi Q6FV12.
KOi K00873.
OMAi YAAPGDQ.
OrthoDBi EOG7M6DJC.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiKPYK2_CANGA
AccessioniPrimary (citable) accession number: Q6FV12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3