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Q6FUV3

- DOHH_CANGA

UniProt

Q6FUV3 - DOHH_CANGA

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Protein
Deoxyhypusine hydroxylase
Gene
LIA1, CAGL0F00407g
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor By similarity.UniRule annotation

Catalytic activityi

[eIF5A]-deoxyhypusine + AH2 + O2 = [eIF5A]-hypusine + A + H2O.UniRule annotation

Cofactori

Binds 2 Fe2+ ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Iron 1 By similarity
Metal bindingi79 – 791Iron 1 By similarity
Metal bindingi111 – 1111Iron 1 By similarity
Metal bindingi112 – 1121Iron 1 By similarity
Metal bindingi236 – 2361Iron 2 By similarity
Metal bindingi237 – 2371Iron 2 By similarity
Metal bindingi269 – 2691Iron 2 By similarity
Metal bindingi270 – 2701Iron 2 By similarity

GO - Molecular functioni

  1. deoxyhypusine monooxygenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. peptidyl-lysine modification to peptidyl-hypusine Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Hypusine biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyhypusine hydroxylase (EC:1.14.99.29)
Short name:
DOHH
Alternative name(s):
Deoxyhypusine dioxygenase
Deoxyhypusine monooxygenase
Gene namesi
Name:LIA1
Ordered Locus Names:CAGL0F00407g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
ProteomesiUP000002428: Chromosome F

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Deoxyhypusine hydroxylaseUniRule annotation
PRO_0000283659Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6FUV3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati109 – 13527HEAT-like PBS-type 1UniRule annotation
Add
BLAST
Repeati203 – 22927HEAT-like PBS-type 2UniRule annotation
Add
BLAST
Repeati234 – 26027HEAT-like PBS-type 3UniRule annotation
Add
BLAST
Repeati267 – 29327HEAT-like PBS-type 4UniRule annotation
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000248665.
KOiK06072.
OMAiFKHEVAF.
OrthoDBiEOG7QC85Z.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
HAMAPiMF_03101. Deoxyhypusine_hydroxylase.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR027517. Deoxyhypusine_hydroxylase.
IPR004155. PBS_lyase_HEAT.
[Graphical view]
SMARTiSM00567. EZ_HEAT. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FUV3-1 [UniParc]FASTAAdd to Basket

« Hide

MSTNFEKHFE ENVDDCNLEQ LRDILVNKEG KSALANRFRA LFNLKTAASE    50
FEANPSDAEK AVQYMGETFG DNSELLKHEV AYVLGQTKNL KAAPLLRKTM 100
LDLAQQPMVR HEAAEALGAL GDKDSLEDLE KCLKNDPHVA VRETCELAIA 150
RINWQHSDAP TKESLQQSLY SSIDPAPPLA LEKEYDLEEL KKLLNDQEKP 200
LFLRYRAMFR LRDIGTDEAV LALASGFNDP SALFKHEIAY VFGQMGSTAA 250
VPSLTEVLGR KEEAPMVRHE AAEALGAIAS EDALPILKQY LNDEVDVVRE 300
SAIVALDMWE YENSNELEYA PA 322
Length:322
Mass (Da):35,970
Last modified:July 19, 2004 - v1
Checksum:i45E5380F9C7D3AC2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380952 Genomic DNA. Translation: CAG58915.1.
RefSeqiXP_445991.1. XM_445991.1.

Genome annotation databases

GeneIDi2887799.
KEGGicgr:CAGL0F00407g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380952 Genomic DNA. Translation: CAG58915.1 .
RefSeqi XP_445991.1. XM_445991.1.

3D structure databases

ProteinModelPortali Q6FUV3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2887799.
KEGGi cgr:CAGL0F00407g.

Phylogenomic databases

HOGENOMi HOG000248665.
KOi K06072.
OMAi FKHEVAF.
OrthoDBi EOG7QC85Z.

Enzyme and pathway databases

UniPathwayi UPA00354 .

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
HAMAPi MF_03101. Deoxyhypusine_hydroxylase.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR027517. Deoxyhypusine_hydroxylase.
IPR004155. PBS_lyase_HEAT.
[Graphical view ]
SMARTi SM00567. EZ_HEAT. 5 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiDOHH_CANGA
AccessioniPrimary (citable) accession number: Q6FUV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 19, 2004
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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