Q6FUS3 (SIL1_CANGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleotide exchange factor SIL1

Gene names

Name:	SIL1
Ordered Locus Names:	CAGL0F01089g

Organism

Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

284593 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces › Candida glabrata

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 By similarity.
Subunit structure	Interacts with KAR2 By similarity.
Subcellular location	Endoplasmic reticulum lumen By similarity.
Sequence similarities	Belongs to the SIL1 family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Endoplasmic reticulum
Domain	Signal
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 339	318	Nucleotide exchange factor SIL1		PRO_0000223361
Regions
	Motif	336 – 339	4	Prevents secretion from ER Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6FUS3 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 45FB1C2135123780	FASTA	339	38,225
	10 20 30 40 50 60 MVAKVWSRVI LIFIATVMVF ASSQQGDANK VNTASPPGAN GIAYASVVAG GSNHVSAAGS 70 80 90 100 110 120 VTGDGVQLPN AEVDIDWLEE HLEDSHDYEK GYDLVEQHFN KLLVGNNADA SFKVRELASR 130 140 150 160 170 180 LILGTLRNNP PVKRLIWDQH PLFVSQVFDL YIGNALKQGS GNPLKYPLLK RYLSILLELI 190 200 210 220 230 240 PFNRDFRFEE DYKDILDKLY TESDVPSDIK IKVLELITLD YSNIKGASGW IDRITNVLTD 250 260 270 280 290 300 SEMGLDELHK RTFFNAMHAL KSEDPKLKLP TNFLNWLAQE TKERAHNLKL AQAQADDNDL 310 320 330 KVRDLEQEEF DQRLVDSRHS VFGNPMAARM KDPYIVDEL

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR380952 Genomic DNA. Translation: CAG58945.1.
RefSeq	XP_446021.1. XM_446021.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2887649.
KEGG	cgr:CAGL0F01089g.
Phylogenomic databases
KO	K14001.
OMA	VFGNPMA.
OrthoDB	EOG40312K.
Family and domain databases
PROSITE	PS00014. ER_TARGET. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SIL1_CANGA

Accession

Primary (citable) accession number: Q6FUS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program