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Protein

Protein-S-isoprenylcysteine O-methyltransferase

Gene

CAGL0F02805g

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferaseUniRule annotation, Transferase
LigandS-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-S-isoprenylcysteine O-methyltransferaseUniRule annotation (EC:2.1.1.100UniRule annotation)
Gene namesi
Ordered Locus Names:CAGL0F02805gImported
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)Imported
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome F

Organism-specific databases

CGDiCAL0131202. CAGL0F02805g.
EuPathDBiFungiDB:CAGL0F02805g.

Subcellular locationi

  • Endoplasmic reticulum membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 56HelicalUniRule annotationAdd BLAST20
Transmembranei63 – 80HelicalUniRule annotationAdd BLAST18
Transmembranei100 – 119HelicalUniRule annotationAdd BLAST20
Transmembranei131 – 149HelicalUniRule annotationAdd BLAST19
Transmembranei192 – 220HelicalUniRule annotationAdd BLAST29

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_446092.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2628. Eukaryota.
COG2020. LUCA.
HOGENOMiHOG000213961.
InParanoidiQ6FUK2.
KOiK00587.
OMAiFRTIAMY.
OrthoDBiEOG092C5DVA.

Family and domain databases

InterProiView protein in InterPro
IPR007269. ICMT_MeTrfase.
IPR025770. PPMT_MeTrfase.
PfamiView protein in Pfam
PF04140. ICMT. 1 hit.
PROSITEiView protein in PROSITE
PS51564. SAM_ICMT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FUK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGSNKSEKF VPDAEGLPVI INGKAYPDIR RNPLDDIAVT SFALGILLGI
60 70 80 90 100
FVGLLTFTQF RNFNVYIIAL SIFHFLEFYV TAKVNPGKVN SDSFLLNNGI
110 120 130 140 150
GYLGAHMFGV LECLVESIFF PNMKKISNSW VAIFLTIIGV ILILLGQVSR
160 170 180 190 200
SMAMYQAGKS FSHILKTEKL DDHTLVTTGI YGYLRHPSYF GFFWWAIGTQ
210 220 230 240 250
LLLLNPIALI VFVGVLWSFF NKRILIEEKY LIQFFGEQYI NYKKRVKVWI

PLID
Length:254
Mass (Da):28,885
Last modified:July 19, 2004 - v1
Checksum:iBD4DBC705FC8F95C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380952 Genomic DNA. Translation: CAG59016.1.
RefSeqiXP_446092.1. XM_446092.1.

Genome annotation databases

EnsemblFungiiCAG59016; CAG59016; CAGL0F02805g.
GeneIDi2887597.
KEGGicgr:CAGL0F02805g.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ6FUK2_CANGA
AccessioniPrimary (citable) accession number: Q6FUK2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: June 7, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported